CRY1 and PER3

Number of citations of the paper that reports this interaction (PMID 10428031)
262

Data Source:
HPRD (in vivo)

		CRY1	PER3
Gene Name		cryptochrome circadian clock 1	period circadian clock 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Transcription Factor Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Ubiquitin Binding	Signal Transducer Activity Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis DNA Repair Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Circadian Regulation Of Gene Expression Regulation Of Circadian Sleep/wake Cycle, Sleep
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARNTL CBLB CSNK1E GRN KRTAP4-12 LTBP4 MDFI PER1 PER2 PER3 PLSCR1 SNRPD3 TIMELESS TRAF2 USP2	9 interactors: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1
Entrez ID		1407	8863
HPRD ID		09050	09138
Ensembl ID		ENSG00000008405	ENSG00000049246
Uniprot IDs		A2I2P0 Q16526	A2I2N5 P56645
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Stimulus Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Hair Cycle Photoperiodism Entrainment Of Circadian Clock Regulation Of JNK Cascade Signal Transduction Cellular Response To Stimulus Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of DNA Binding Regulation Of Protein Transport Negative Regulation Of Signaling Regulation Of Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Regulation Of Nitrogen Compound Metabolic Process	Circadian Regulation Of Gene Expression Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Photoperiodism Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Hair Cycle Entrainment Of Circadian Clock Blue Light Signaling Pathway Regulation Of Signal Transduction Response To Blue Light Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Circadian Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Hormone Secretion Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Signaling Cell Communication RNA Biosynthetic Process Response To Light Stimulus Regulation Of Type B Pancreatic Cell Development Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stimulus Protein-chromophore Linkage Response To Radiation Cellular Response To Radiation Positive Regulation Of Wnt Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process
Tagcloud ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow	aanat2 bmal1 bmal1b circadian clock cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish
Tagcloud (Difference) ?		adjust breeders cry2 cryptochrome destroy deubiquitination hydrocarbon hypothalamus kaput melatonin pars per1 photoperiod pineal proteasome proteasomes rhythms scn suprachiasmatic translocator tuberalis widow	aanat2 bmal1b cry1aa cry1ba cry1bb dark darkness dd enhances hour implicating ld locomotor nuclease orphan per1b period2 represses roralpha rore talen vertebrate zebrafish
Tagcloud (Intersection) ?		bmal1 circadian clock erbalpha per2 rev