CRY1 and KRTAP4-12

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		CRY1	KRTAP4-12
Gene Name		cryptochrome circadian clock 1	keratin associated protein 4-12
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Keratin Filament
	Molecular Function	Nucleotide Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Transcription Factor Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Ubiquitin Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis DNA Repair Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARNTL CBLB CSNK1E GRN KRTAP4-12 LTBP4 MDFI PER1 PER2 PER3 PLSCR1 SNRPD3 TIMELESS TRAF2 USP2	107 interactors: ADAMTSL4 ALPP AQP1 ATG12 ATN1 BAHD1 BEX2 C10orf62 C19orf66 CATSPER1 CBX2 CCDC116 CCDC185 CCNK CDC42EP1 CHCHD3 CHIC2 CLDN2 CNNM3 CNTFR COL8A1 CRCT1 CREB5 CRY1 DBF4B DLK2 EIF4E2 FAM107A FAM27E3 FAM76B FBXL18 FBXW5 GLRX3 GNE GPATCH2L GPRIN2 GRAP2 HHEX HOXA1 HOXB9 IFI30 ILF3 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP26-1 KRTAP3-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 LCE1B LCE2D LCE3E LCE4A LINGO1 LNX1 MAPKBP1 MEOX2 MRPL4 NOTCH2NL NPDC1 NUDT18 NUFIP2 OTX1 PCSK5 PDGFRB PFKL PHLDA1 PLSCR1 PLSCR4 PNKP PRKAB2 PRR13 QPRT RERE RPS28 SLC25A10 SLC25A6 SMCP SPATA3 SPG7 SPRY2 TAP1 TBC1D16 TBC1D23 TCEB3B THAP10 THAP7 TOP3B TXNDC5 ZBTB16 ZNF165 ZNF20 ZNF250 ZNF408 ZNF415 ZNF417 ZNF426 ZNF439 ZNF440 ZNF581 ZNF638 ZNF655 ZNF764 ZSCAN26
Entrez ID		1407	83755
HPRD ID		09050	13941
Ensembl ID		ENSG00000008405	ENSG00000213416
Uniprot IDs		A2I2P0 Q16526	Q9BQ66
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Stimulus Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Hair Cycle Photoperiodism Entrainment Of Circadian Clock Regulation Of JNK Cascade Signal Transduction Cellular Response To Stimulus Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of DNA Binding Regulation Of Protein Transport Negative Regulation Of Signaling Regulation Of Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Regulation Of Nitrogen Compound Metabolic Process	Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process RNA Biosynthetic Process Transcription, DNA-templated Biosynthetic Process Gene Expression RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Cellular Metabolic Process Regulation Of RNA Metabolic Process Keratinization Anterior/posterior Pattern Specification Regulation Of Cellular Process Regulation Of Metabolic Process Cellular Process Keratinocyte Differentiation Embryo Development Phospholipid Scrambling Metanephric Glomerulus Vasculature Development Pattern Specification Process Metanephric Glomerulus Development Epidermal Cell Differentiation Epidermis Development Mitochondrion Organization Metabolic Process Forebrain Morphogenesis Transcription From RNA Polymerase II Promoter Glomerulus Vasculature Development Multicellular Organismal Development Organic Anion Transport Inner Ear Development Cell Migration Involved In Coronary Angiogenesis Hepatic Duct Development Abducens Nerve Formation Metanephric Mesenchymal Cell Migration Transepithelial Water Transport Renin Secretion Into Blood Stream Metanephric Descending Thin Limb Development DGDP Catabolic Process Metanephric Proximal Straight Tubule Development Metanephric Proximal Convoluted Tubule Segment 2 Development
Tagcloud ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow
Tagcloud (Difference) ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow
Tagcloud (Intersection) ?