PER3 and CLOCK

Number of citations of the paper that reports this interaction (PMID 14701732)
33

Data Source:
HPRD (in vivo)

		PER3	CLOCK
Gene Name		period circadian clock 3	clock circadian regulator
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Nucleoplasm Transcription Factor Complex Chromosome Cytosol Chromatoid Body Intracellular Membrane-bounded Organelle
	Molecular Function	Signal Transducer Activity Protein Binding Kinase Binding Ubiquitin Protein Ligase Binding	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Histone Acetyltransferase Activity Signal Transducer Activity Protein Binding Chromatin DNA Binding Sequence-specific DNA Binding Protein Dimerization Activity E-box Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Signal Transduction Circadian Regulation Of Gene Expression Regulation Of Circadian Sleep/wake Cycle, Sleep	DNA Damage Checkpoint Chromatin Organization Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Transcription From RNA Polymerase II Promoter Signal Transduction Spermatogenesis Circadian Rhythm Photoperiodism Histone Acetylation Circadian Regulation Of Gene Expression Regulation Of Hair Cycle Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Inflammatory Response Regulation Of Insulin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Response To Redox State Cellular Response To Ionizing Radiation Regulation Of Type B Pancreatic Cell Development Negative Regulation Of Glucocorticoid Receptor Signaling Pathway
Pathways			PPARA activates gene expression Chromatin modifying enzymes Fatty acid, triacylglycerol, and ketone body metabolism Metabolism of lipids and lipoproteins Chromatin organization Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) REV-ERBA represses gene expression HATs acetylate histones BMAL1:CLOCK,NPAS2 activates circadian gene expression RORA activates circadian gene expression
Drugs
Diseases
GWAS			Personality dimensions ( 18957941)
Protein-Protein Interactions		9 interactors: ARNTL CLOCK CRY1 CRY2 CSNK1D CSNK1E PER1 PER2 SP1	7 interactors: ARNTL ARNTL2 EP300 KAT2B PER3 RARA RXRA
Entrez ID		8863	9575
HPRD ID		09138	03508
Ensembl ID		ENSG00000049246	ENSG00000134852
Uniprot IDs		A2I2N5 P56645	O15516 Q3ZCT4 Q53EU0
PDB IDs			4H10
Enriched GO Terms of Interacting Partners?		Circadian Regulation Of Gene Expression Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Rhythmic Process Circadian Rhythm Regulation Of Circadian Rhythm Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Photoperiodism Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Regulation Of Hair Cycle Entrainment Of Circadian Clock Blue Light Signaling Pathway Regulation Of Signal Transduction Response To Blue Light Nucleobase-containing Compound Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Circadian Regulation Of Translation Negative Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Nitrogen Compound Metabolic Process Signal Transduction Regulation Of Hormone Secretion Negative Regulation Of Gene Expression Nitrogen Compound Metabolic Process Negative Regulation Of Biosynthetic Process Transcription, DNA-templated Signaling Cell Communication RNA Biosynthetic Process Response To Light Stimulus Regulation Of Type B Pancreatic Cell Development Response To Redox State Positive Regulation Of Canonical Wnt Signaling Pathway Cellular Protein Metabolic Process Cellular Response To Stimulus Protein-chromophore Linkage Response To Radiation Cellular Response To Radiation Positive Regulation Of Wnt Signaling Pathway RNA Metabolic Process Cellular Protein Modification Process Negative Regulation Of Cellular Metabolic Process	Rhythmic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Circadian Rhythm Transcription, DNA-templated RNA Biosynthetic Process N-terminal Peptidyl-lysine Acetylation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process RNA Metabolic Process Transcription From RNA Polymerase II Promoter Gene Expression Regulation Of Circadian Rhythm Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Transcription, DNA-templated N-terminal Protein Amino Acid Acetylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Positive Regulation Of Circadian Rhythm Regulation Of RNA Metabolic Process Negative Regulation Of Gene Expression Nucleobase-containing Compound Metabolic Process Positive Regulation Of Cellular Metabolic Process Negative Regulation Of Biosynthetic Process Transcription Initiation From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Retinoic Acid Receptor Signaling Pathway N-terminal Protein Amino Acid Modification Signal Transduction Ventricular Cardiac Muscle Cell Differentiation DNA-templated Transcription, Initiation Negative Regulation Of Transcription From RNA Polymerase II Promoter Nitrogen Compound Metabolic Process Signaling Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Cell Communication Positive Regulation Of Metabolic Process Regulation Of Cell Cycle
Tagcloud ?		aanat2 bmal1 bmal1b circadian clock cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish	albuginea bothersome bump bumps corporal corpus correcting curvature disadvantages dorsum entails erection impotence intercourse neurovascular nonabsorbable palpable penis phenylephrine plication plications priapism recurred requested spongiosum straighter straightness sutures thickest tunica
Tagcloud (Difference) ?		aanat2 bmal1 bmal1b circadian clock cry1aa cry1ba cry1bb dark darkness dd enhances erbalpha hour implicating ld locomotor nuclease orphan per1b per2 period2 represses rev roralpha rore talen vertebrate zebrafish	albuginea bothersome bump bumps corporal corpus correcting curvature disadvantages dorsum entails erection impotence intercourse neurovascular nonabsorbable palpable penis phenylephrine plication plications priapism recurred requested spongiosum straighter straightness sutures thickest tunica
Tagcloud (Intersection) ?