CRY1 and MDFI

Number of citations of the paper that reports this interaction (PMID 16189514)
699

Data Source:
HPRD (two hybrid)

		CRY1	MDFI
Gene Name		cryptochrome circadian clock 1	MyoD family inhibitor
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Mitochondrion	Nucleus Cytoplasm
	Molecular Function	Nucleotide Binding Transcription Factor Binding Transcription Factor Activity Core Promoter Sequence-specific DNA Binding Core Promoter Binding DNA Binding Double-stranded DNA Binding Deoxyribodipyrimidine Photo-lyase Activity DNA (6-4) Photolyase Activity Protein Binding Transcription Factor Binding Blue Light Photoreceptor Activity Protein Kinase Binding Phosphatase Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Ubiquitin Binding	Protein Binding Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Gluconeogenesis DNA Repair Transcription, DNA-templated DNA Damage Induced Protein Phosphorylation Circadian Rhythm Blue Light Signaling Pathway Protein-chromophore Linkage Lipid Storage Negative Regulation Of Protein Ubiquitination Response To Insulin Circadian Regulation Of Gene Expression Response To Glucagon Glucose Homeostasis Regulation Of Circadian Rhythm Negative Regulation Of Circadian Rhythm Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Transcription, DNA-templated Regulation Of DNA Damage Checkpoint Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Negative Regulation Of Glucocorticoid Secretion	Negative Regulation Of Transcription From RNA Polymerase II Promoter Activation Of JUN Kinase Activity Embryo Development Dorsal/ventral Axis Specification Negative Regulation Of Wnt Signaling Pathway Cytoplasmic Sequestering Of Transcription Factor Negative Regulation Of DNA Binding Embryonic Skeletal System Morphogenesis Trophoblast Giant Cell Differentiation
Pathways		BMAL1:CLOCK,NPAS2 activates circadian gene expression
Drugs
Diseases
GWAS
Protein-Protein Interactions		15 interactors: ARNTL CBLB CSNK1E GRN KRTAP4-12 LTBP4 MDFI PER1 PER2 PER3 PLSCR1 SNRPD3 TIMELESS TRAF2 USP2	225 interactors: AANAT AASDHPPT ADAMTSL3 AKAP17A AP5Z1 APLN AQP1 AQP5 ARHGAP32 ARID5A ATG12 ATN1 ATXN7L2 AVPI1 B3GNT9 BAALC BAHD1 BBS2 BEX1 C10orf62 C14orf105 C17orf70 C19orf60 C19orf66 C20orf195 C22orf39 C4orf26 C5orf30 C6orf165 C8orf33 C8orf48 CATSPER1 CBFA2T2 CBX2 CC2D1B CCDC116 CCDC120 CCDC185 CCDC33 CCER1 CDC42EP1 CDCA7L CDKL3 CEP57L1 CHIC2 CLPB CNNM3 CPSF3L CREB5 CRX CRY1 CSNK1G2-AS1 CXCL16 CYBA DAAM2 DBF4B DCAF8 DCANP1 DDX19A DHRS1 DKK1 DMRT3 DNPEP DOCK2 DUSP6 EBI3 EIF4A2 EIF4E2 ENKD1 ETNK2 EWSR1 FAM124B FAM161A FAM27E3 FASTK FBXL18 FBXO34 FBXW5 FES FOXD4L6 FZD9 GATA2 GDF15 GLIDR GNAI2 GNG5 GPATCH2L GPRIN2 GTF3C5 HEYL HNRNPLL HOXA1 HOXB9 HTR1B ILF3 IQUB KAT5 KIAA0040 KIAA0408 KIF1A KPNA2 KRAS LASP1 LCE1B LCE3E LCE4A LIMS2 LINC00636 LINC01588 LMO3 LOC148413 LOC149950 LRCH4 LRRN4 MAGED1 MAGEF1 MAPKBP1 MCM5 METTL17 MFSD3 MGAT5B MVP MYF5 MYOD1 MYOG NAB2 NDUFA7 NEU4 NPDC1 NR1H2 NR1H3 OLIG3 OTX1 PARP11 PBXIP1 PDGFB PDIA5 PGLS PHLDA1 PID1 PIDD1 PIH1D2 PIN1 PLEKHG4 POM121L8P PRKAB2 PTPMT1 PVRL2 RABL6 REG3A RFX2 RIPPLY1 RTP5 SERF2 SFI1 SIX1 SLC25A10 SLC35A2 SLC9A1 SPATA3 SPATA8 SPG7 SPRY1 SPRY2 TAP1 TCEB3 TCF3 TGIF1 THAP7 THEG TIE1 TINAGL1 TMEM241 TNNI1 TNP2 TRAF3IP2 TRPC1 TRPV6 TSC2 TTC23 TTLL10 TUSC2 TYMSOS TYRO3 UBC USP20 USP6 VHL VPS72 WDYHV1 WNT11 ZBTB24 ZBTB25 ZBTB9 ZFYVE26 ZNF101 ZNF124 ZNF136 ZNF138 ZNF155 ZNF205 ZNF223 ZNF230 ZNF264 ZNF266 ZNF408 ZNF417 ZNF426 ZNF433 ZNF439 ZNF440 ZNF490 ZNF559 ZNF564 ZNF578 ZNF581 ZNF587 ZNF607 ZNF646 ZNF670 ZNF679 ZNF707 ZNF764 ZNF79 ZNF844
Entrez ID		1407	4188
HPRD ID		09050	07280
Ensembl ID		ENSG00000008405	ENSG00000112559
Uniprot IDs		A2I2P0 Q16526	B1AKB6 Q99750
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Circadian Rhythm Circadian Regulation Of Gene Expression Circadian Rhythm Rhythmic Process Regulation Of Protein Metabolic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Circadian Regulation Of Translation Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Negative Regulation Of Glucocorticoid Receptor Signaling Pathway Response To Stimulus Regulation Of Signaling Regulation Of Metabolic Process Regulation Of Signal Transduction Regulation Of Protein Catabolic Process Regulation Of Gene Expression Entrainment Of Circadian Clock By Photoperiod Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Skeletal Muscle Tissue Development Regulation Of Hair Cycle Photoperiodism Entrainment Of Circadian Clock Regulation Of JNK Cascade Signal Transduction Cellular Response To Stimulus Cellular Metabolic Process Transcription, DNA-templated Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Stress-activated MAPK Cascade Regulation Of Transcription, DNA-templated Histone H3 Deacetylation Regulation Of Nucleic Acid-templated Transcription RNA Biosynthetic Process Regulation Of RNA Biosynthetic Process Signaling Regulation Of RNA Metabolic Process Cell Communication Negative Regulation Of Signal Transduction Negative Regulation Of DNA Binding Regulation Of Protein Transport Negative Regulation Of Signaling Regulation Of Binding Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Regulation Of Proteolysis Regulation Of Establishment Of Protein Localization Regulation Of Nitrogen Compound Metabolic Process	Transcription, DNA-templated RNA Biosynthetic Process Macromolecule Biosynthetic Process Cellular Macromolecule Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Gene Expression Regulation Of RNA Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Gene Expression Biosynthetic Process Regulation Of Metabolic Process Nucleobase-containing Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Regulation Of Cellular Process Negative Regulation Of Biosynthetic Process Negative Regulation Of Cellular Metabolic Process Cellular Process Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Cellular Metabolic Process Negative Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Developmental Process Cellular Response To Organic Substance Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Metabolic Process Multicellular Organismal Development Positive Regulation Of Transcription From RNA Polymerase II Promoter Cell Differentiation Positive Regulation Of Myoblast Fusion Cell Fate Commitment Positive Regulation Of Skeletal Muscle Fiber Development Anatomical Structure Development Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Syncytium Formation By Plasma Membrane Fusion Regulation Of Myoblast Fusion Transcription From RNA Polymerase II Promoter Organ Development Metabolic Process
Tagcloud ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow
Tagcloud (Difference) ?		adjust bmal1 breeders circadian clock cry2 cryptochrome destroy deubiquitination erbalpha hydrocarbon hypothalamus kaput melatonin pars per1 per2 photoperiod pineal proteasome proteasomes rev rhythms scn suprachiasmatic translocator tuberalis widow
Tagcloud (Intersection) ?