ATF6B and MBTPS1

Number of citations of the paper that reports this interaction (PMID 11163209)
293

Data Source:
HPRD (in vivo)

		ATF6B	MBTPS1
Gene Name		activating transcription factor 6 beta	membrane-bound transcription factor peptidase, site 1
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	Serine-type Endopeptidase Activity
	Biological Process	Transcription, DNA-templated Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress Regulation Of Transcription Factor Import Into Nucleus Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways			Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725) Prostate cancer ( 23535732)
Protein-Protein Interactions		9 interactors: ATF6 CDK6 CREBZF MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	10 interactors: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8
Entrez ID		1388	8720
HPRD ID		02992	04522
Ensembl ID		ENSG00000213676	ENSG00000140943
Uniprot IDs		Q6AZW6 Q99941	Q14703
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Positive Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase Activity Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Kinase Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Transcription, DNA-templated RNA Biosynthetic Process Membrane Protein Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process RNA Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lactation Locus Ceruleus Development Cell Dedifferentiation Trochlear Nerve Formation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development	Positive Regulation Of Protein Modification Process Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine Positive Regulation Of Protein Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Secretion Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Signaling Regulation Of Protein Metabolic Process Cell Communication Response To Anesthetic Positive Regulation Of Corticotropin-releasing Hormone Secretion Response To Fluoxetine Response To L-glutamate Sphingoid Catabolic Process Positive Regulation Of Cell Development Response To Organic Substance Defense Response Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Ubiquitination Regulation Of Secretion Taste Bud Development Dendrite Extension Cellular Response To Norepinephrine Stimulus Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Osteoclast Proliferation Axon Target Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
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