MBTPS1 and ZBED8

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		MBTPS1	ZBED8
Gene Name		membrane-bound transcription factor peptidase, site 1	zinc finger, BED-type containing 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Golgi Apparatus Golgi Stack Integral Component Of Membrane	Nucleoplasm
	Molecular Function	Serine-type Endopeptidase Activity	Nucleic Acid Binding
	Biological Process	Proteolysis Lipid Metabolic Process Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Lysosome Organization Cholesterol Metabolic Process Endoplasmic Reticulum Unfolded Protein Response Membrane Protein Intracellular Domain Proteolysis Response To Endoplasmic Reticulum Stress Regulation Of Transcription Factor Import Into Nucleus Cellular Protein Metabolic Process Small Molecule Metabolic Process
Pathways		Regulation of cholesterol biosynthesis by SREBP (SREBF) Metabolism of lipids and lipoproteins ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: ATF6B BDNF BIRC3 C11orf58 CANX CDK2AP2 SPHK1 TNFRSF14 TNFSF11 ZBED8	6 interactors: EED EEF1G HSF4 KIAA1377 MBTPS1 NAB2
Entrez ID		8720	63920
HPRD ID		04522	17430
Ensembl ID		ENSG00000140943	ENSG00000221886
Uniprot IDs		Q14703	Q8IZ13
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Modification Process Cellular Response To Tumor Necrosis Factor Response To Tumor Necrosis Factor Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Protein Metabolic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Cytokine Positive Regulation Of Protein Phosphorylation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Phosphorylation Positive Regulation Of Secretion Cellular Response To Organic Substance Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Metabolic Process Response To Stress Regulation Of Protein Phosphorylation Signaling Regulation Of Protein Metabolic Process Cell Communication Response To Anesthetic Positive Regulation Of Corticotropin-releasing Hormone Secretion Response To Fluoxetine Response To L-glutamate Sphingoid Catabolic Process Positive Regulation Of Cell Development Response To Organic Substance Defense Response Regulation Of Corticotropin-releasing Hormone Secretion Positive Regulation Of ERK1 And ERK2 Cascade Via TNFSF11-mediated Signaling TNFSF11-mediated Signaling Pathway Positive Regulation Of Fever Generation By Positive Regulation Of Prostaglandin Secretion Positive Regulation Of NF-kappaB Transcription Factor Activity Cellular Response To Cytokine Stimulus Positive Regulation Of Protein Ubiquitination Regulation Of Secretion Taste Bud Development Dendrite Extension Cellular Response To Norepinephrine Stimulus Regulation Of Retinal Cell Programmed Cell Death Positive Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of Osteoclast Development Positive Regulation Of Transport Cell Surface Receptor Signaling Pathway Osteoclast Proliferation Axon Target Recognition Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Negative Regulation Of Transcription From RNA Polymerase III Promoter Negative Regulation Of Transcription, DNA-templated Histone H3-K9 Demethylation Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Histone H3-K27 Methylation Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Histone H3-K27 Methylation Organelle Organization Histone Modification Membrane Protein Intracellular Domain Proteolysis Protein Homotrimerization
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