ATF6B and ATF6

Number of citations of the paper that reports this interaction (PMID 11158310)
58

Data Source:
HPRD (in vitro)

		ATF6B	ATF6
Gene Name		activating transcription factor 6 beta	activating transcription factor 6
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Intracellular Nucleus Endoplasmic Reticulum Membrane Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex	Golgi Membrane Nucleus Nuclear Envelope Nucleoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Membrane Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	Sequence-specific DNA Binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding CAMP Response Element Binding
	Biological Process	Transcription, DNA-templated Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Protein Folding Response To Stress Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Signal Transduction Endoplasmic Reticulum Unfolded Protein Response Cellular Protein Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways			ATF4 activates genes PERK regulates gene expression ATF6-alpha activates chaperone genes ATF6-alpha activates chaperones Unfolded Protein Response (UPR)
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725) Prostate cancer ( 23535732)	Parkinson's disease (age of onset) ( 19772629)
Protein-Protein Interactions		9 interactors: ATF6 CDK6 CREBZF MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	14 interactors: APP ATF6B BPGM CREB1 CREB3L3 DDC GTF2I NFYA NFYC NNMT SRF TNFRSF1A XBP1 YY1
Entrez ID		1388	22926
HPRD ID		02992	16118
Ensembl ID		ENSG00000213676	ENSG00000118217
Uniprot IDs		Q6AZW6 Q99941	A8K383 P18850
PDB IDs
Enriched GO Terms of Interacting Partners?		Activation Of Signaling Protein Activity Involved In Unfolded Protein Response Positive Regulation Of Nuclease Activity Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Cellular Response To Topologically Incorrect Protein Response To Unfolded Protein Positive Regulation Of Gene Expression Response To Endoplasmic Reticulum Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Positive Regulation Of Metabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Protein Kinase Activity Membrane Protein Intracellular Domain Proteolysis Positive Regulation Of Kinase Activity Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Regulation Of Metabolic Process Positive Regulation Of Transferase Activity Transcription, DNA-templated RNA Biosynthetic Process Membrane Protein Proteolysis Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of RNA Biosynthetic Process Positive Regulation Of Phosphorylation Regulation Of DNA-templated Transcription In Response To Stress Regulation Of RNA Metabolic Process Positive Regulation Of Protein Modification Process RNA Metabolic Process Positive Regulation Of Hydrolase Activity Positive Regulation Of Lactation Locus Ceruleus Development Cell Dedifferentiation Trochlear Nerve Formation Positive Regulation Of Plasma Cell Differentiation Serotonin Secretion, Neurotransmission Epithelial Cell Maturation Involved In Salivary Gland Development	Positive Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cellular Biosynthetic Process Transcription From RNA Polymerase II Promoter Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Transcription, DNA-templated RNA Metabolic Process RNA Biosynthetic Process Regulation Of Transcription, DNA-templated Nitrogen Compound Metabolic Process Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Response To Organic Substance Regulation Of RNA Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Gene Expression Regulation Of Gene Expression Regulation Of Nitrogen Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Cellular Metabolic Process Cellular Response To Stress Endoplasmic Reticulum Unfolded Protein Response Cellular Response To Unfolded Protein ER-nucleus Signaling Pathway Nucleobase-containing Compound Metabolic Process Cellular Response To Topologically Incorrect Protein Cellular Response To Organic Substance Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Biosynthetic Process Response To Unfolded Protein Response To Organonitrogen Compound Response To Endoplasmic Reticulum Stress Cellular Response To Stimulus Response To Toxic Substance Response To Hormone Small Molecule Metabolic Process Response To Drug Cellular Chemical Homeostasis Response To Stress Response To Abiotic Stimulus Erythrocyte Development Cellular Response To Nutrient Regulation Of Metabolic Process Positive Regulation Of Fat Cell Differentiation
Tagcloud ?			ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Difference) ?			ca1 ca3 cerebellar cerebellum colliculus dentate developmentally germinal grp78 grp94 gyrus immature inducer insults manf matured misfolded neurodevelopmental parietal pd12 pd25 pd4 pons subcutaneously subiculum tunicamycin unfolded upr xbp1s
Tagcloud (Intersection) ?