MME and PIK3CB

Number of citations of the paper that reports this interaction (PMID 12529960)
2

Data Source:
HPRD (in vitro, in vivo)

		MME	PIK3CB
Gene Name		membrane metallo-endopeptidase	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome	Nucleus Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex
	Molecular Function	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding	Protein Binding ATP Binding 1-phosphatidylinositol-3-kinase Activity Phosphatidylinositol 3-kinase Activity 1-phosphatidylinositol-4-phosphate 3-kinase Activity Insulin Receptor Substrate Binding Phosphatidylinositol-4,5-bisphosphate 3-kinase Activity
	Biological Process	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence	Activation Of MAPK Activity Regulation Of Cell-matrix Adhesion Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cellular Calcium Ion Homeostasis Autophagy Chemotaxis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Blood Coagulation Insulin Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway Positive Regulation Of Autophagy Phosphatidylinositol 3-kinase Signaling Cell Migration Platelet Activation Phosphatidylinositol-3-phosphate Biosynthetic Process Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Embryonic Cleavage Small Molecule Metabolic Process Innate Immune Response Phosphatidylinositol Phosphorylation Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Phosphatidylinositol-mediated Signaling T Cell Receptor Signaling Pathway Leukocyte Migration Platelet Aggregation Regulation Of Clathrin-mediated Endocytosis
Pathways		Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins	Signaling by the B Cell Receptor (BCR) Signaling by GPCR Metabolism of lipids and lipoproteins Signaling by FGFR in disease Signaling by EGFRvIII in Cancer Signaling by SCF-KIT Downstream signaling events of B Cell Receptor (BCR) DAP12 signaling PI3K/AKT activation Interleukin receptor SHC signaling PI-3K cascade Role of phospholipids in phagocytosis Phospholipid metabolism Fcgamma receptor (FCGR) dependent phagocytosis PI3K Cascade Signaling by PDGF DAP12 interactions GAB1 signalosome G-protein beta:gamma signalling Signaling by ERBB4 Constitutive PI3K/AKT Signaling in Cancer Role of LAT2/NTAL/LAB on calcium mobilization PI3K events in ERBB4 signaling Signaling by ERBB2 Signaling by EGFR GPCR downstream signaling TCR signaling Signaling by Interleukins Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Nephrin interactions Interleukin-2 signaling PI3K/AKT Signaling in Cancer Platelet activation, signaling and aggregation Interleukin-3, 5 and GM-CSF signaling Adaptive Immune System Downstream TCR signaling IRS-mediated signalling PIP3 activates AKT signaling IGF1R signaling cascade VEGFA-VEGFR2 Pathway Synthesis of PIPs at the plasma membrane IRS-related events triggered by IGF1R G beta:gamma signalling through PI3Kgamma PI3K events in ERBB2 signaling Regulation of signaling by CBL Downstream signaling of activated FGFR PI Metabolism Innate Immune System Signaling by Insulin receptor Signalling by NGF Insulin receptor signalling cascade IRS-related events Cytokine Signaling in Immune system Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane Tie2 Signaling Signaling by Overexpressed Wild-Type EGFR in Cancer Cell surface interactions at the vascular wall Signaling by FGFR IRS-mediated signalling Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) GPVI-mediated activation cascade Interleukin receptor SHC signaling PI3K Cascade
Drugs		Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS
Protein-Protein Interactions		16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP	10 interactors: AGTR2 ALAS1 DVL3 HCK HPS6 MME PIK3R1 PRKCD PRKCE YWHAQ
Entrez ID		4311	5291
HPRD ID		00392	04234
Ensembl ID		ENSG00000196549
Uniprot IDs		P08473	B4DER4 P42338
PDB IDs		1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Phagocytosis Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Transport Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Circulatory Renin-angiotensin Regulation Of Receptor Activity Blood Coagulation Hemostasis Immune Response-regulating Signaling Pathway Intracellular Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Cellular Response To Organic Substance Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Regulation Of Cellular Component Organization Regulation Of Actin Filament Polymerization Positive Regulation Of Lipid Catabolic Process Intrinsic Apoptotic Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Exploration Behavior Platelet Activation Response To Fibroblast Growth Factor Regulation Of Body Fluid Levels Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Actin Polymerization Or Depolymerization Regulation Of Actin Filament Length Wound Healing Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Positive Regulation Of Immune Response Endocytosis Defense Response Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Lipopolysaccharide-mediated Signaling Pathway Regulation Of Establishment Of Protein Localization Response To Wounding Cellular Localization Regulation Of Apoptotic Process Regulation Of Phosphorus Metabolic Process Positive Regulation Of Dephosphorylation Activation Of Phospholipase C Activity Response To Organic Substance Regulation Of Lipid Metabolic Process Regulation Of Protein Localization
Tagcloud ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Difference) ?		adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod	amico atm dissect entered erg formalin fusions hiseq illumina map2k5 maximise mek5 men1 nbpf10 ncor2 needle ngs opening qiagen read routinely screen sections spop technologies templates tmprrs2 unstained yielded
Tagcloud (Intersection) ?