COL5A2 and DDR1

Number of citations of the paper that reports this interaction (PMID 9659900)
78

Data Source:
HPRD (in vivo)

		COL5A2	DDR1
Gene Name		collagen, type V, alpha 2	discoidin domain receptor tyrosine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Molecular_function Extracellular Matrix Structural Constituent SMAD Binding Metal Ion Binding	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Skeletal System Development Ossification Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Skin Development Eye Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Embryo Implantation Lactation Negative Regulation Of Cell Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Non-integrin membrane-ECM interactions
Drugs			Imatinib
Diseases
GWAS			Age-related macular degeneration ( 23455636) HIV-1 control ( 20041166) Ulcerative colitis ( 20848476)
Protein-Protein Interactions		2 interactors: BMP1 DDR1	17 interactors: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR
Entrez ID		1290	780
HPRD ID		00366	02678
Ensembl ID		ENSG00000204262	ENSG00000204580
Uniprot IDs		P05997	Q08345 Q96T61 Q96T62
PDB IDs		1A9A	3ZOS 4AG4 4BKI 4BKJ
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell-matrix Adhesion Extracellular Matrix Organization Extracellular Structure Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Wound Healing, Spreading Of Cells Regulation Of Extracellular Matrix Organization Organ Morphogenesis Muscle Cell Migration Cartilage Condensation Mammary Gland Alveolus Development Mammary Gland Lobule Development Branching Involved In Mammary Gland Duct Morphogenesis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cartilage Development Morphogenesis Of An Epithelial Sheet Mammary Gland Duct Morphogenesis Lactation Embryo Implantation Tissue Development Mammary Gland Morphogenesis Mammary Gland Epithelium Development Regulation Of Cartilage Development Extracellular Matrix Disassembly Regulation Of Cell-matrix Adhesion Body Fluid Secretion Anatomical Structure Morphogenesis Gland Morphogenesis Cell-matrix Adhesion Mammary Gland Development Lipoprotein Metabolic Process Regulation Of Cell-substrate Adhesion Branching Morphogenesis Of An Epithelial Tube Organ Development Cartilage Development Cell-substrate Adhesion Protein Autophosphorylation Ear Development Female Pregnancy Morphogenesis Of A Branching Epithelium	Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Fibril Organization Collagen Catabolic Process Axon Guidance Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuron Projection Development Cell Development Heart Development Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Generation Of Neurons Extracellular Matrix Organization Extracellular Structure Organization Fibroblast Growth Factor Receptor Signaling Pathway Neuron Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Anatomical Structure Morphogenesis Regulation Of Kinase Activity Locomotion Response To External Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Projection Morphogenesis Cell Differentiation Neurotrophin Signaling Pathway Cardiovascular System Development Cell Part Morphogenesis Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Skeletal System Development Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Sensory Organ Development Regulation Of MAP Kinase Activity
Tagcloud ?		arid1a atlas backgroundover bayesian built c19orf53 causal conclusionsthe correspond cskn2a1 galnt10 graph graphical hub integrative logit ovarian overlooking probabilistic psg11 quantify resultswe seed selector shed stepwise suppressors tcga tremendous	biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts
Tagcloud (Difference) ?		arid1a atlas backgroundover bayesian built c19orf53 causal conclusionsthe correspond cskn2a1 galnt10 graph graphical hub integrative logit ovarian overlooking probabilistic psg11 quantify resultswe seed selector shed stepwise suppressors tcga tremendous	biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts
Tagcloud (Intersection) ?