DDR1

Gene Name		discoidin domain receptor tyrosine kinase 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Embryo Implantation Lactation Negative Regulation Of Cell Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion
Pathways		Non-integrin membrane-ECM interactions
Drugs		Imatinib
Diseases
GWAS		Age-related macular degeneration ( 23455636) HIV-1 control ( 20041166) Ulcerative colitis ( 20848476)
Protein-protein Interactions		17 interactors: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR
Entrez ID		780
HPRD ID		02678
Ensembl ID		ENSG00000204580
Uniprot IDs		Q08345 Q96T61 Q96T62
PDB IDs		3ZOS 4AG4 4BKI 4BKJ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Fibril Organization Collagen Catabolic Process Axon Guidance Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuron Projection Development Cell Development Heart Development Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Generation Of Neurons Extracellular Matrix Organization Extracellular Structure Organization Fibroblast Growth Factor Receptor Signaling Pathway Neuron Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Anatomical Structure Morphogenesis Regulation Of Kinase Activity Locomotion Response To External Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Projection Morphogenesis Cell Differentiation Neurotrophin Signaling Pathway Cardiovascular System Development Cell Part Morphogenesis Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Skeletal System Development Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Sensory Organ Development Regulation Of MAP Kinase Activity
Tagcloud ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts