DDR1 and BEND5

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
HPRD (two hybrid)

		DDR1	BEND5
Gene Name		discoidin domain receptor tyrosine kinase 1	BEN domain containing 5
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex Extracellular Vesicular Exosome	Golgi Apparatus
	Molecular Function	Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding Collagen Binding ATP Binding Protein Tyrosine Kinase Collagen Receptor Activity Metal Ion Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Cell-matrix Adhesion Cell Adhesion Embryo Implantation Lactation Negative Regulation Of Cell Proliferation Regulation Of Extracellular Matrix Disassembly Smooth Muscle Cell Migration Extracellular Matrix Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Peptidyl-tyrosine Autophosphorylation Ear Development Wound Healing, Spreading Of Cells Protein Autophosphorylation Branching Involved In Mammary Gland Duct Morphogenesis Mammary Gland Alveolus Development Smooth Muscle Cell-matrix Adhesion
Pathways		Non-integrin membrane-ECM interactions
Drugs		Imatinib
Diseases
GWAS		Age-related macular degeneration ( 23455636) HIV-1 control ( 20041166) Ulcerative colitis ( 20848476)
Protein-Protein Interactions		17 interactors: BEND5 COL11A1 COL2A1 COL3A1 COL5A2 FRS2 MAPK6 NCK2 NUDT3 PLCG1 PTPN11 RGS2 SHC1 SNAPIN SNRNP40 TM4SF1 TTR	20 interactors: APP BUD31 BZRAP1 CTNNBIP1 DDR1 EIF3D FAM161A GFI1B GORASP2 GRAP2 LCE1B PRKAB2 RTP5 UBE2I USP2 USP20 USP7 VPS25 ZGPAT ZNF417
Entrez ID		780	79656
HPRD ID		02678	07756
Ensembl ID		ENSG00000204580
Uniprot IDs		Q08345 Q96T61 Q96T62	Q7L4P6
PDB IDs		3ZOS 4AG4 4BKI 4BKJ
Enriched GO Terms of Interacting Partners?		Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Collagen Fibril Organization Collagen Catabolic Process Axon Guidance Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Extracellular Matrix Disassembly Neuron Projection Development Cell Development Heart Development Axonogenesis Axon Development Cellular Response To Growth Factor Stimulus Neuron Development Cell Morphogenesis Involved In Neuron Differentiation Response To Growth Factor Chemotaxis Movement Of Cell Or Subcellular Component Neuron Projection Morphogenesis Generation Of Neurons Extracellular Matrix Organization Extracellular Structure Organization Fibroblast Growth Factor Receptor Signaling Pathway Neuron Differentiation Neurogenesis Cell Morphogenesis Involved In Differentiation Cell Projection Organization Regulation Of Protein Kinase Activity Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Anatomical Structure Morphogenesis Regulation Of Kinase Activity Locomotion Response To External Stimulus Neurotrophin TRK Receptor Signaling Pathway Cellular Response To Organonitrogen Compound Cell Projection Morphogenesis Cell Differentiation Neurotrophin Signaling Pathway Cardiovascular System Development Cell Part Morphogenesis Fc-epsilon Receptor Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Skeletal System Development Activation Of Protein Kinase Activity Fc Receptor Signaling Pathway Sensory Organ Development Regulation Of MAP Kinase Activity	Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteasomal Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Cellular Protein Catabolic Process Regulation Of Cellular Protein Metabolic Process Protein Deubiquitination Protein Catabolic Process Regulation Of Receptor Activity Protein Modification By Small Protein Removal Regulation Of Protein Metabolic Process Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Gene Expression Cellular Macromolecule Catabolic Process Regulation Of Proteasomal Protein Catabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Positive Regulation Of SUMO Transferase Activity Regulation Of Metabolic Process Regulation Of Protein Tyrosine Kinase Activity Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Proteolysis Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Smooth Muscle Cell-matrix Adhesion Regulation Of Vascular Permeability Involved In Acute Inflammatory Response Synaptic Growth At Neuromuscular Junction Formation Of Cytoplasmic Translation Initiation Complex Regulation Of ERBB Signaling Pathway Regulation Of Nitrogen Compound Metabolic Process Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Protein Targeting To Vacuole Involved In Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Collateral Sprouting In Absence Of Injury Negative Regulation Of Gene Expression Cellular Protein Metabolic Process Negative Regulation Of DNA-templated Transcription, Initiation Negative Regulation Of Transcription Initiation From RNA Polymerase II Promoter Negative Regulation Of Biosynthetic Process Regulation Of Protein Catabolic Process Cellular Process Collateral Sprouting Axon Midline Choice Point Recognition Positive Regulation Of Mitotic Cell Cycle Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity
Tagcloud ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts	app apps aptamer deliver delivery endothelial entrapped evaporation flurbiprofen functionalized glycol importantly loaded micelles murine offer peg pla polyethylene polylactic quantified retention solvent spectroscopy therapeutically transferrin transferring unmodified w
Tagcloud (Difference) ?		biomarker bxpc3 clonogenic collagen contribution depending discoidin elucidate exogenous fundamental influences knockdown member microarray migration oncogenic phenotypic recapitulating reciprocal secreted shrna silencing subsequently tgfbeta tgfbi tumorigenesis upregulated xenograft xenografts	app apps aptamer deliver delivery endothelial entrapped evaporation flurbiprofen functionalized glycol importantly loaded micelles murine offer peg pla polyethylene polylactic quantified retention solvent spectroscopy therapeutically transferrin transferring unmodified w
Tagcloud (Intersection) ?