COL5A2 and BMP1

Number of citations of the paper that reports this interaction (PMID 11741999)
25

Data Source:
HPRD (in vivo)

		COL5A2	BMP1
Gene Name		collagen, type V, alpha 2	bone morphogenetic protein 1
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Collagen Type V Trimer Endoplasmic Reticulum Lumen Extracellular Matrix	Extracellular Region Proteinaceous Extracellular Matrix Extracellular Space Golgi Apparatus Membrane-bounded Vesicle
	Molecular Function	Molecular_function Extracellular Matrix Structural Constituent SMAD Binding Metal Ion Binding	Metalloendopeptidase Activity Cytokine Activity Calcium Ion Binding Growth Factor Activity Peptidase Activity Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Skeletal System Development Ossification Axon Guidance Extracellular Matrix Disassembly Extracellular Matrix Organization Collagen Fibril Organization Collagen Catabolic Process Skin Development Eye Morphogenesis Cellular Response To Amino Acid Stimulus Negative Regulation Of Endodermal Cell Differentiation	Skeletal System Development Cartilage Condensation Ossification Proteolysis Multicellular Organismal Development Extracellular Matrix Disassembly Cell Differentiation Extracellular Matrix Organization Lipoprotein Metabolic Process Small Molecule Metabolic Process Positive Regulation Of Cartilage Development
Pathways		Signaling by PDGF NCAM1 interactions Collagen formation Axon guidance Collagen degradation Non-integrin membrane-ECM interactions Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures Syndecan interactions ECM proteoglycans Integrin cell surface interactions Collagen biosynthesis and modifying enzymes NCAM signaling for neurite out-growth	Collagen formation Crosslinking of collagen fibrils Anchoring fibril formation Collagen biosynthesis and modifying enzymes Degradation of the extracellular matrix Assembly of collagen fibrils and other multimeric structures
Drugs
Diseases
GWAS			Hypertriglyceridemia ( 23505323)
Protein-Protein Interactions		2 interactors: BMP1 DDR1	14 interactors: ADRA1A CHRD COL1A1 COL5A1 COL5A2 COL7A1 GEM HSPG2 LAMA3 LAMB3 LAMC2 TP53 TWSG1 YLPM1
Entrez ID		1290	649
HPRD ID		00366	00209
Ensembl ID		ENSG00000204262	ENSG00000168487
Uniprot IDs		P05997	P13497
PDB IDs		1A9A	3EDG 3EDH
Enriched GO Terms of Interacting Partners?		Smooth Muscle Cell-matrix Adhesion Extracellular Matrix Organization Extracellular Structure Organization Collagen-activated Tyrosine Kinase Receptor Signaling Pathway Collagen-activated Signaling Pathway Smooth Muscle Cell Migration Regulation Of Extracellular Matrix Disassembly Wound Healing, Spreading Of Cells Regulation Of Extracellular Matrix Organization Organ Morphogenesis Muscle Cell Migration Cartilage Condensation Mammary Gland Alveolus Development Mammary Gland Lobule Development Branching Involved In Mammary Gland Duct Morphogenesis Peptidyl-tyrosine Autophosphorylation Positive Regulation Of Cartilage Development Morphogenesis Of An Epithelial Sheet Mammary Gland Duct Morphogenesis Lactation Embryo Implantation Tissue Development Mammary Gland Morphogenesis Mammary Gland Epithelium Development Regulation Of Cartilage Development Extracellular Matrix Disassembly Regulation Of Cell-matrix Adhesion Body Fluid Secretion Anatomical Structure Morphogenesis Gland Morphogenesis Cell-matrix Adhesion Mammary Gland Development Lipoprotein Metabolic Process Regulation Of Cell-substrate Adhesion Branching Morphogenesis Of An Epithelial Tube Organ Development Cartilage Development Cell-substrate Adhesion Protein Autophosphorylation Ear Development Female Pregnancy Morphogenesis Of A Branching Epithelium	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Gastrulation Tissue Development Formation Of Primary Germ Layer Embryonic Morphogenesis Anatomical Structure Formation Involved In Morphogenesis Hemidesmosome Assembly Collagen Catabolic Process Embryo Development Anatomical Structure Morphogenesis Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Anatomical Structure Development Ossification Negative Regulation Of Endodermal Cell Differentiation Epithelium Development Developmental Process Endodermal Cell Differentiation Cell Differentiation Cell-substrate Junction Assembly Multicellular Organismal Development Endoderm Formation Collagen Fibril Organization Epidermis Development Endoderm Development Collagen Biosynthetic Process Negative Regulation Of Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Cell Adhesion Regulation Of Embryonic Development Negative Regulation Of Cell Differentiation Head Development Organ Development Negative Regulation Of Embryonic Development Regulation Of Cell Differentiation Organ Morphogenesis Cell Junction Assembly Regulation Of Gastrulation Cartilage Development Involved In Endochondral Bone Morphogenesis Skeletal System Development Endochondral Ossification Skin Development Negative Regulation Of BMP Signaling Pathway Response To External Stimulus Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Connective Tissue Development Negative Regulation Of Osteoblast Differentiation Cellular Response To Amino Acid Stimulus
Tagcloud ?		arid1a atlas backgroundover bayesian built c19orf53 causal conclusionsthe correspond cskn2a1 galnt10 graph graphical hub integrative logit ovarian overlooking probabilistic psg11 quantify resultswe seed selector shed stepwise suppressors tcga tremendous	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Difference) ?		arid1a atlas backgroundover bayesian built c19orf53 causal conclusionsthe correspond cskn2a1 galnt10 graph graphical hub integrative logit ovarian overlooking probabilistic psg11 quantify resultswe seed selector shed stepwise suppressors tcga tremendous	augment c1r c1s cub embryogenesis fli1a founding gata1 hbbe1 hematopoiesis hierarchy injecting maternally mesoderm morphants morphogenetic morpholino mount mpo myelomonocytic oligonucleotide plastin primitive pu scube scube1 uegf zebrafish
Tagcloud (Intersection) ?