CKS2 and LDHB

Number of citations of the paper that reports this interaction (PMID 19786724)
4

Data Source:
BioGRID (pull down)

		CKS2	LDHB
Gene Name		CDC28 protein kinase regulatory subunit 2	lactate dehydrogenase B
Image
Gene Ontology Annotations	Cellular Component		Cytoplasm Mitochondrion Cytosol Membrane Extracellular Vesicular Exosome
	Molecular Function	Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity	L-lactate Dehydrogenase Activity Protein Binding Kinase Binding Identical Protein Binding NAD Binding
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Meiosis I Cell Proliferation Cell Division	Lactate Metabolic Process Pyruvate Metabolic Process NAD Metabolic Process Cellular Metabolic Process Cellular Carbohydrate Metabolic Process Small Molecule Metabolic Process Oxidation-reduction Process
Pathways			Pyruvate metabolism Abnormal metabolism in phenylketonuria Pyruvate metabolism and Citric Acid (TCA) cycle The citric acid (TCA) cycle and respiratory electron transport
Drugs			NADH Nicotinamide-Adenine-Dinucleotide 4-Hydroxy-1,2,5-Oxadiazole-3-Carboxylic Acid Oxamic Acid
Diseases
GWAS
Protein-Protein Interactions		16 interactors: CCNA1 CCNA2 CCNB1 CCNB2 CDC37 CDK1 CDK2 CKS1B EEF1A1 GRB2 HSP90AA1 LDHB SSBP1 TSC22D4 UNC119 VTN	7 interactors: CKS1B CKS2 LDHA PEX5 POT1 SUMO4 TERF1
Entrez ID		1164	3945
HPRD ID		00300	01026
Ensembl ID		ENSG00000123975	ENSG00000111716
Uniprot IDs		P33552	P07195 Q5U077
PDB IDs		1CKS	1I0Z 1T2F
Enriched GO Terms of Interacting Partners?		G2/M Transition Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Cell Cycle Phase Transition Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division Mitotic Cell Cycle Process Mitotic Cell Cycle Regulation Of Catalytic Activity Regulation Of Phosphorylation Regulation Of Phosphorus Metabolic Process Cell Cycle Process Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Regulation Of Kinase Activity Mitotic Nuclear Division Cell Cycle Regulation Of Cell Cycle G1/S Transition Of Mitotic Cell Cycle Regulation Of Cellular Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Mitotic Nuclear Envelope Disassembly Histone Phosphorylation Nuclear Envelope Disassembly Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Ligase Activity Involved In Mitotic Cell Cycle Ras Protein Signal Transduction Nuclear Envelope Organization Anaphase-promoting Complex-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Ubiquitin-protein Transferase Activity Mitotic DNA Damage Checkpoint Mitotic DNA Integrity Checkpoint Mitotic G2 DNA Damage Checkpoint Nucleus Organization Ventricular Cardiac Muscle Cell Development Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Metabolic Process DNA Damage Checkpoint Mitotic Cell Cycle Checkpoint Ventricular Cardiac Muscle Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Immune Response G2 DNA Damage Checkpoint Regulation Of Cell Cycle Process Cellular Response To Stress Positive Regulation Of Heart Growth Regulation Of Protein Ubiquitination Regulation Of Nitrogen Compound Metabolic Process Regulation Of Mitotic Cell Cycle Phase Transition	Negative Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of Telomerase Activity Telomere Maintenance Via Telomerase Negative Regulation Of Telomere Maintenance Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomerase Activity Regulation Of Telomere Maintenance RNA-dependent DNA Replication Negative Regulation Of DNA Biosynthetic Process Telomere Maintenance Via Telomere Lengthening Regulation Of DNA Biosynthetic Process Negative Regulation Of DNA Replication Telomere Maintenance Cell Division Negative Regulation Of Chromosome Organization Positive Regulation Of DNA Strand Elongation Negative Regulation Of DNA Metabolic Process Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Protein Homotetramerization Negative Regulation Of Telomere Maintenance Via Semi-conservative Replication Regulation Of DNA Replication Protein Import Into Peroxisome Matrix, Translocation Telomeric Loop Formation Age-dependent Telomere Shortening Telomere Formation Via Telomerase Protein Import Into Peroxisome Matrix, Docking Telomere Maintenance Via Telomere Shortening Regulation Of Chromosome Organization Telomere Capping Negative Regulation Of Protein Homooligomerization Positive Regulation Of Helicase Activity Regulation Of Cell Cycle Positive Regulation Of Telomerase Activity Telomere Assembly Positive Regulation Of Telomere Maintenance Via Telomerase Protein Import Into Peroxisome Membrane Protein To Membrane Docking Mitotic Cell Cycle Phase Transition Peroxisomal Membrane Transport Cell Cycle Phase Transition Cell Cycle Process Replicative Cell Aging Negative Regulation Of Protein Oligomerization Regulation Of Catalytic Activity DNA Replication Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Telomere Maintenance Negative Regulation Of Transferase Activity Regulation Of Protein Complex Assembly Positive Regulation Of Microtubule Polymerization
Tagcloud ?		abundance antisense cdk2 cdnas contains cyclin disappears element encoding entry exists fraction greatly interference microinjection oligonucleotides p19 p21 p45 p9cks1 pcna prevented quaternary rearrangements reconstitution requires substantial transformed whose	basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple
Tagcloud (Difference) ?		abundance antisense cdk2 cdnas contains cyclin disappears element encoding entry exists fraction greatly interference microinjection oligonucleotides p19 p21 p45 p9cks1 pcna prevented quaternary rearrangements reconstitution requires substantial transformed whose	basal bimodal cancers chemotherapy datasets dehydrogenase dependence glycolytic heterogeneous highest lactate linking metabolic microarray molecularly neoadjuvant pam50 pathologic phenotypes posttreatment predict predicted predictive relapse robust scoring subtypes subtyping triple
Tagcloud (Intersection) ?