ADCYAP1 and MME

Number of citations of the paper that reports this interaction (PMID 9313778)
6

Data Source:
HPRD (in vitro)

		ADCYAP1	MME
Gene Name		adenylate cyclase activating polypeptide 1 (pituitary)	membrane metallo-endopeptidase
Image
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Terminal Bouton	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Brush Border Focal Adhesion Synaptic Vesicle Integral Component Of Membrane Axon Dendrite Neuron Projection Terminus Synapse Extracellular Vesicular Exosome
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Neuropeptide Hormone Activity Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Endopeptidase Activity Metalloendopeptidase Activity Protein Binding Exopeptidase Activity Zinc Ion Binding Peptide Binding
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Neuron Projection Development Positive Regulation Of Interleukin-6 Production Positive Regulation Of Rap GTPase Activity Regulation Of Protein Localization Negative Regulation Of Rho GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter ATP Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Somatostatin Secretion	Kidney Development Angiotensin Maturation Proteolysis Peptide Metabolic Process Sensory Perception Of Pain Cellular Protein Metabolic Process Creatinine Metabolic Process Beta-amyloid Metabolic Process Cellular Response To Cytokine Stimulus Cellular Response To UV-A Cellular Response To UV-B Replicative Senescence
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Activation of TRKA receptors Glucagon-type ligand receptors NGF signalling via TRKA from the plasma membrane GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling NGF-independant TRKA activation Class B/2 (Secretin family receptors)	Peptide hormone metabolism Metabolism of Angiotensinogen to Angiotensins
Drugs			Candoxatril N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1\'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan
Diseases
GWAS		Obesity-related traits ( 23251661)
Protein-Protein Interactions		8 interactors: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	16 interactors: ADCYAP1 ADM AGT CSNK2A1 CSNK2B EDN1 EDN2 GAST LYN NDRG1 NPPA NPPC PIK3CB PIK3R1 SHC1 VIP
Entrez ID		116	4311
HPRD ID		02369	00392
Ensembl ID		ENSG00000141433	ENSG00000196549
Uniprot IDs		P18509	P08473
PDB IDs		1GEA 2D2P 2JOD	1DL9 1DMT 1QVD 1R1H 1R1I 1R1J 1Y8J 2QPJ 2YB9
Enriched GO Terms of Interacting Partners?		Activation Of Adenylate Cyclase Activity Protein Processing Positive Regulation Of Adenylate Cyclase Activity Sex Differentiation Positive Regulation Of Lyase Activity Cell Surface Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Development Of Primary Female Sexual Characteristics Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Polarity Specification Of Anterior/posterior Axis Digestion Cellular Response To Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cellular Response To UV-A Regulation Of Proteolysis Cerebellar Granule Cell Precursor Proliferation Developmental Process Involved In Reproduction Hormone Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Luteolysis Creatinine Metabolic Process Positive Regulation Of Immature T Cell Proliferation	Positive Regulation Of Vasodilation Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Vasodilation Signaling Cell Communication Regulation Of Phosphorus Metabolic Process Regulation Of Cell Proliferation Positive Regulation Of Cell Proliferation Positive Regulation Of Heart Rate Regulation Of Blood Vessel Size Regulation Of Tube Size Cellular Response To Stimulus Response To Hormone Positive Regulation Of Heart Contraction Cell Activation Positive Regulation Of Metabolic Process Regulation Of CAMP Metabolic Process Response To Peptide Hormone Artery Smooth Muscle Contraction Response To Peptide Regulation Of Kinase Activity Tonic Smooth Muscle Contraction Positive Regulation Of Protein Metabolic Process Response To Insulin Cellular Chemical Homeostasis Positive Regulation Of Signal Transduction Regulation Of Catalytic Activity Second-messenger-mediated Signaling Blood Circulation Response To External Stimulus Intracellular Signal Transduction Response To Stimulus Cellular Response To Hormone Stimulus Response To Organic Substance Regulation Of Vasoconstriction Positive Regulation Of Cellular Metabolic Process Vascular Smooth Muscle Contraction Histamine Secretion Negative Regulation Of Cell Proliferation Regulation Of Signal Transduction Cellular Homeostasis Regulation Of Heart Rate Cellular Metal Ion Homeostasis Response To Abiotic Stimulus Phosphate-containing Compound Metabolic Process Histamine Transport Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Multicellular Organismal Development
Tagcloud ?			adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Difference) ?			adh alb albinism arbitrarily assortment backcrossing constitution duplicate electrophoretically fumarate glo glucosephosphate glyoxalase gpd homeologous hydratase intersubspecies isocitrate malic mannosephosphate midh mpi numbered phosphorylase provisionally sme sorbitol sord ssod
Tagcloud (Intersection) ?