ADCYAP1 and ADCYAP1R1

Number of citations of the paper that reports this interaction (PMID 10583729)
19

Data Source:
HPRD (in vitro, in vivo)

		ADCYAP1	ADCYAP1R1
Gene Name		adenylate cyclase activating polypeptide 1 (pituitary)	adenylate cyclase activating polypeptide 1 (pituitary) receptor type I
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Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Terminal Bouton	Endosome Rough Endoplasmic Reticulum Plasma Membrane Integral Component Of Plasma Membrane Caveola Tight Junction Cell Surface Neuron Projection Receptor Complex
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Neuropeptide Hormone Activity Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Receptor Activity Vasoactive Intestinal Polypeptide Receptor Activity Protein Binding Adenylate Cyclase Binding ADP-ribosylation Factor Binding Neuropeptide Binding
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Neuron Projection Development Positive Regulation Of Interleukin-6 Production Positive Regulation Of Rap GTPase Activity Regulation Of Protein Localization Negative Regulation Of Rho GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter ATP Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Somatostatin Secretion	Cell Surface Receptor Signaling Pathway Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Activation Of Phospholipase C Activity Spermatogenesis Positive Regulation Of Calcium Ion Transport Into Cytosol CAMP-mediated Signaling Cell Differentiation Response To Estradiol Multicellular Organismal Response To Stress Response To Drug Response To Ethanol Development Of Primary Female Sexual Characteristics Neurotrophin TRK Receptor Signaling Pathway Negative Regulation Of Cell Death Positive Regulation Of Inositol Phosphate Biosynthetic Process
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Activation of TRKA receptors Glucagon-type ligand receptors NGF signalling via TRKA from the plasma membrane GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling NGF-independant TRKA activation Class B/2 (Secretin family receptors)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Activation of TRKA receptors Glucagon-type ligand receptors NGF signalling via TRKA from the plasma membrane GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling NGF-independant TRKA activation Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Major depressive disorder ( 21621269)
Protein-Protein Interactions		8 interactors: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	2 interactors: ADCYAP1 CALM1
Entrez ID		116	117
HPRD ID		02369	00045
Ensembl ID		ENSG00000141433	ENSG00000078549
Uniprot IDs		P18509	P41586
PDB IDs		1GEA 2D2P 2JOD	2JOD 3N94
Enriched GO Terms of Interacting Partners?		Activation Of Adenylate Cyclase Activity Protein Processing Positive Regulation Of Adenylate Cyclase Activity Sex Differentiation Positive Regulation Of Lyase Activity Cell Surface Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Development Of Primary Female Sexual Characteristics Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Polarity Specification Of Anterior/posterior Axis Digestion Cellular Response To Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cellular Response To UV-A Regulation Of Proteolysis Cerebellar Granule Cell Precursor Proliferation Developmental Process Involved In Reproduction Hormone Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Luteolysis Creatinine Metabolic Process Positive Regulation Of Immature T Cell Proliferation	Activation Of Adenylate Cyclase Activity Positive Regulation Of Adenylate Cyclase Activity Positive Regulation Of Lyase Activity Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process Positive Regulation Of Cyclic Nucleotide Metabolic Process Regulation Of CAMP Biosynthetic Process Negative Regulation Of Ion Transport Regulation Of CAMP Metabolic Process Second-messenger-mediated Signaling Response To Glucocorticoid Response To Corticosteroid Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Negative Regulation Of Transport Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of High Voltage-gated Calcium Channel Activity Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Protein Kinase Activity Response To Steroid Hormone Positive Regulation Of Kinase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Transferase Activity Positive Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Positive Regulation Of Growth Hormone Secretion Cellular Response To Growth Factor Stimulus Synaptic Transmission Response To Growth Factor Regulation Of Ion Transport Secretion Regulation Of Oligodendrocyte Progenitor Proliferation Negative Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Growth Hormone Secretion Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Positive Regulation Of Protein Phosphorylation Negative Regulation Of Glial Cell Proliferation Detection Of Calcium Ion Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Transport Regulation Of Protein Kinase Activity Regulation Of Cell Communication By Electrical Coupling Brain Development Positive Regulation Of Phosphoprotein Phosphatase Activity
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