ADCYAP1 and CPAMD8

Number of citations of the paper that reports this interaction (PMID 1335692)
2

Data Source:
BioGRID (unspecified method)

		ADCYAP1	CPAMD8
Gene Name		adenylate cyclase activating polypeptide 1 (pituitary)	C3 and PZP-like, alpha-2-macroglobulin domain containing 8
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Extracellular Space Terminal Bouton	Extracellular Space Plasma Membrane
	Molecular Function	Receptor Signaling Protein Activity Receptor Binding Neuropeptide Hormone Activity Pituitary Adenylate Cyclase Activating Polypeptide Activity Pituitary Adenylate Cyclase-activating Polypeptide Receptor Binding Peptide Hormone Receptor Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Ovarian Follicle Development Behavioral Fear Response Histamine Secretion Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Activation Of Adenylate Cyclase Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Neuropeptide Signaling Pathway Cell-cell Signaling Female Pregnancy Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Cell Proliferation Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Neuron Projection Development Sensory Perception Of Pain CAMP-mediated Signaling Pituitary Gland Development Neuron Projection Development Positive Regulation Of Interleukin-6 Production Positive Regulation Of Rap GTPase Activity Regulation Of Protein Localization Negative Regulation Of Rho GTPase Activity Response To Starvation Negative Regulation Of Potassium Ion Transport Response To Ethanol Negative Regulation Of Cell Cycle Positive Regulation Of Protein Kinase Activity Positive Regulation Of Vasodilation Positive Regulation Of Transcription From RNA Polymerase II Promoter ATP Metabolic Process Neurotrophin TRK Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Postsynaptic Membrane Potential Positive Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Regulation Of Oligodendrocyte Progenitor Proliferation Cellular Response To Glucocorticoid Stimulus Positive Regulation Of Somatostatin Secretion	Negative Regulation Of Endopeptidase Activity
Pathways		Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR Signalling by NGF G alpha (s) signalling events Activation of TRKA receptors Glucagon-type ligand receptors NGF signalling via TRKA from the plasma membrane GPCR ligand binding Metabolic disorders of biological oxidation enzymes GPCR downstream signaling NGF-independant TRKA activation Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Obesity-related traits ( 23251661)	Brain lesion load ( 19010793) Crohn's disease ( 22412388)
Protein-Protein Interactions		8 interactors: ADCYAP1R1 CASP2 CPAMD8 MME SCTR SHH VIPR1 VIPR2	3 interactors: ADCYAP1 DPP4 SCTR
Entrez ID		116	27151
HPRD ID		02369	09892
Ensembl ID		ENSG00000141433	ENSG00000160111
Uniprot IDs		P18509	Q6NVW5 Q8IZJ3
PDB IDs		1GEA 2D2P 2JOD
Enriched GO Terms of Interacting Partners?		Activation Of Adenylate Cyclase Activity Protein Processing Positive Regulation Of Adenylate Cyclase Activity Sex Differentiation Positive Regulation Of Lyase Activity Cell Surface Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Positive Regulation Of CAMP Biosynthetic Process Regulation Of Cyclase Activity Positive Regulation Of CAMP Metabolic Process G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cyclic Nucleotide Metabolic Process Negative Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Ureter Smooth Muscle Cell Differentiation Positive Regulation Of Sclerotome Development Multicellular Structure Septum Development Negative Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Kidney Smooth Muscle Cell Differentiation Positive Regulation Of Skeletal Muscle Cell Proliferation Regulation Of Mesenchymal Cell Proliferation Involved In Prostate Gland Development Mesenchymal Smoothened Signaling Pathway Involved In Prostate Gland Development Regulation Of CAMP Biosynthetic Process Regulation Of CAMP Metabolic Process Development Of Primary Female Sexual Characteristics Epithelial-mesenchymal Signaling Involved In Prostate Gland Development Right Lung Development Primary Prostatic Bud Elongation Intein-mediated Protein Splicing Polarity Specification Of Anterior/posterior Axis Digestion Cellular Response To Stimulus Regulation Of Nodal Signaling Pathway Involved In Determination Of Lateral Mesoderm Left/right Asymmetry Metanephric Mesenchymal Cell Proliferation Involved In Metanephros Development Left Lung Development Cellular Response To UV-A Regulation Of Proteolysis Cerebellar Granule Cell Precursor Proliferation Developmental Process Involved In Reproduction Hormone Metabolic Process Positive Regulation Of Immature T Cell Proliferation In Thymus Cell Proliferation In Hindbrain Positive Regulation Of Smooth Muscle Cell Differentiation Prostate Epithelial Cord Elongation Specification Of Axis Polarity Positive Regulation Of Mesenchymal Cell Proliferation Involved In Ureter Development Positive Regulation Of Hh Target Transcription Factor Activity Negative Regulation Of Cholesterol Efflux Luteolysis Creatinine Metabolic Process Positive Regulation Of Immature T Cell Proliferation	Positive Regulation Of Somatostatin Secretion Negative Regulation Of Acute Inflammatory Response To Non-antigenic Stimulus Negative Regulation Of Extracellular Matrix Organization Negative Regulation Of Extracellular Matrix Disassembly Negative Regulation Of Acute Inflammatory Response To Antigenic Stimulus Positive Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Regulation Of Adenylate Cyclase Activity Involved In G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Growth Hormone Secretion Regulation Of Cell-cell Adhesion Mediated By Integrin Regulation Of Oligodendrocyte Progenitor Proliferation Regulation Of Growth Hormone Secretion Negative Regulation Of Glial Cell Proliferation Negative Regulation Of Inflammatory Response To Antigenic Stimulus Negative Regulation Of Rho GTPase Activity Negative Regulation Of Acute Inflammatory Response Histamine Secretion Positive Regulation Of Rap GTPase Activity Histamine Transport Negative Regulation Of Ras GTPase Activity Regulation Of Rap GTPase Activity CAMP-mediated Signaling Negative Regulation Of Potassium Ion Transport Positive Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Rap Protein Signal Transduction Positive Regulation Of Cell Proliferation Activation Of Adenylate Cyclase Activity Cyclic-nucleotide-mediated Signaling Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Vasodilation Negative Regulation Of GTPase Activity Negative Regulation Of Muscle Cell Apoptotic Process Positive Regulation Of Adenylate Cyclase Activity Behavioral Fear Response Regulation Of Extracellular Matrix Organization Fear Response Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Vasodilation Excretion Positive Regulation Of Lyase Activity Cellular Response To Glucocorticoid Stimulus Cellular Response To Corticosteroid Stimulus Adenylate Cyclase-activating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Regulation Of Muscle Cell Apoptotic Process Pituitary Gland Development Regulation Of Adenylate Cyclase Activity
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