PRRT2 and SNAP25

Number of citations of the paper that reports this interaction (PMID 16169070)
531

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		PRRT2	SNAP25
Gene Name		proline-rich transmembrane protein 2	synaptosomal-associated protein, 25kDa
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Cell Junction Synapse	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Growth Cone BLOC-1 Complex SNARE Complex Vesicle Presynaptic Membrane Neuron Projection Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex
	Molecular Function		SNAP Receptor Activity Protein Binding Syntaxin-1 Binding Calcium-dependent Protein Binding
	Biological Process	Response To Biotic Stimulus Neuromuscular Process Controlling Posture	Neurotransmitter Uptake Energy Reserve Metabolic Process Synaptic Transmission Neurotransmitter Secretion Pathogenesis Regulation Of Neuron Projection Development Glutamate Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Small Molecule Metabolic Process Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization
Pathways			Dopamine Neurotransmitter Release Cycle Integration of energy metabolism Toxicity of botulinum toxin type E (BoNT/E) Toxicity of botulinum toxin type A (BoNT/A) Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Toxicity of botulinum toxin type C (BoNT/C) Norepinephrine Neurotransmitter Release Cycle GABA synthesis, release, reuptake and degradation Glutamate Neurotransmitter Release Cycle Uptake and actions of bacterial toxins Neurotransmitter Release Cycle Neurotoxicity of clostridium toxins Serotonin Neurotransmitter Release Cycle Transmission across Chemical Synapses
Drugs			Botulinum Toxin Type A
Diseases
GWAS			Cardiac hypertrophy ( 21348951)
Protein-Protein Interactions		1 interactors: SNAP25	34 interactors: APP CCDC53 CENPF CPLX1 DNM1 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 VAMP2 VAMP7 VAMP8 ZDHHC17
Entrez ID		112476	6616
HPRD ID		13995	02637
Ensembl ID		ENSG00000167371	ENSG00000132639
Uniprot IDs		Q7Z6L0	P60880
PDB IDs			1KIL 1XTG 3RK2 3RK3 3RL0 3ZUR
Enriched GO Terms of Interacting Partners?		Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Membrane Neurotransmitter Uptake Glutamate Secretion Long-term Synaptic Potentiation Vesicle Fusion Synaptic Vesicle Exocytosis Acid Secretion Vesicle Docking Involved In Exocytosis Organelle Fusion Vesicle Docking Dicarboxylic Acid Transport Membrane Docking Neurotransmitter Secretion Synaptic Vesicle Transport Positive Regulation Of Synaptic Transmission Membrane Fusion Energy Reserve Metabolic Process Regulation Of Neurotransmitter Levels Amino Acid Transport Neurotransmitter Transport Regulation Of Synaptic Plasticity Regulation Of Insulin Secretion Establishment Of Vesicle Localization Pathogenesis Vesicle Organization Vesicle Localization Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Energy Derivation By Oxidation Of Organic Compounds Carboxylic Acid Transport Regulation Of Synaptic Transmission Organic Acid Transport Establishment Of Organelle Localization Exocytosis Cellular Protein Complex Assembly Regulation Of Neuron Projection Development Regulation Of Protein Secretion Generation Of Precursor Metabolites And Energy Organelle Localization Organic Anion Transport Regulation Of Cell Projection Organization Secretion By Cell Regulation Of Neuron Differentiation	Membrane Fusion Exocytosis Vesicle-mediated Transport Vesicle Fusion Synaptic Vesicle Exocytosis Synaptic Vesicle Transport Establishment Of Localization In Cell Secretion By Cell Organelle Fusion Establishment Of Vesicle Localization Vesicle Localization Regulation Of Exocytosis Secretion Neurotransmitter Secretion Cellular Localization Transport Establishment Of Organelle Localization Regulation Of Cellular Localization Synaptic Transmission Regulation Of Neurotransmitter Levels Regulation Of Secretion Organelle Localization Neurotransmitter Transport Membrane Organization Regulation Of Vesicle-mediated Transport Synaptic Vesicle Fusion To Presynaptic Membrane Protein Transport Vesicle Organization Establishment Of Protein Localization Cell-cell Signaling Vesicle Docking Intracellular Transport Membrane Docking Protein Localization Positive Regulation Of Exocytosis Calcium Ion-dependent Exocytosis Regulation Of Hormone Secretion Intracellular Protein Transport Regulation Of Cellular Component Organization Positive Regulation Of Transport Glutamate Secretion Regulation Of Synaptic Transmission Golgi Vesicle Transport Post-Golgi Vesicle-mediated Transport Regulation Of Protein Localization Positive Regulation Of Synaptic Transmission Regulation Of Insulin Secretion Cellular Protein Localization Regulation Of Peptide Hormone Secretion Acid Secretion
Tagcloud ?		324delca 649delc 650insc 905insg affected august bfie causative clusters d302gfsx39 diarrhea epilepsy familial families febrile hotspot infantile members mutation peking phenotypes probands proline r217efsx12 sanger seizure seizures september t108sfsx25	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Difference) ?		324delca 649delc 650insc 905insg affected august bfie causative clusters d302gfsx39 diarrhea epilepsy familial families febrile hotspot infantile members mutation peking phenotypes probands proline r217efsx12 sanger seizure seizures september t108sfsx25	anterograde axonal axons blunt breakdown bulbous bulbs caudate circumscribed disorganized immunocytochemical immunoreactivity insult map5 mca neurofilament nf68kd nonischemic occlusion permeating precedes reminiscent roughened sequalae subcortical swellings synaptosomal territory tracts
Tagcloud (Intersection) ?