TPPP and CDK11B

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		TPPP	CDK11B
Gene Name		tubulin polymerization promoting protein	cyclin-dependent kinase 11B
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Protein Binding Microtubule Binding Tubulin Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding
	Biological Process	Microtubule Bundle Formation Positive Regulation Of Protein Complex Assembly Positive Regulation Of Protein Polymerization Microtubule Polymerization	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Cell Proliferation Regulation Of MRNA Processing Regulation Of Cell Cycle
Pathways			G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes
Drugs
Diseases
GWAS		Ulcerative colitis ( 20228799)
Protein-Protein Interactions		5 interactors: APP CDK11B GAPDH GSK3B HDAC6	22 interactors: AP2M1 CASP1 CASP3 CASP8 CCND3 CCNL2 EIF3F KAT7 MSN PAK1 PIN1 RANBP9 RPS27A TCEA2 TH TPPP URM1 YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		11076	984
HPRD ID		18522	08909
Ensembl ID		ENSG00000171368	ENSG00000248333
Uniprot IDs		O94811 Q4L233	P21127
PDB IDs
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Cell Death Death Cellular Protein Modification Process Neuron Apoptotic Process Cellular Response To Heat Neuron Death Regulation Of Growth Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Peptidyl-cysteine S-trans-nitrosylation Hsp90 Deacetylation Regulation Of Proteolysis Cellular Protein Metabolic Process Response To Heat Regulation Of Cellular Protein Metabolic Process Regulation Of Receptor Activity Negative Regulation Of Cellular Metabolic Process Negative Regulation Of Catalytic Activity Regulation Of Protein Metabolic Process Innate Immune Response Regulation Of Protein Binding Regulation Of Gene Expression Negative Regulation Of Type B Pancreatic Cell Development Positive Regulation Of Chaperone-mediated Protein Complex Assembly Synaptic Growth At Neuromuscular Junction Superior Temporal Gyrus Development Polyubiquitinated Misfolded Protein Transport Regulation Of Microtubule-based Process Positive Regulation Of Protein Complex Assembly Re-entry Into Mitotic Cell Cycle Collateral Sprouting In Absence Of Injury Negative Regulation Of Neuron Maturation Peptidyl-amino Acid Modification Response To Temperature Stimulus Negative Regulation Of Neuron Differentiation Protein Metabolic Process Regulation Of Gene Expression, Epigenetic Hypermethylation Of CpG Island Negative Regulation Of Hydrogen Peroxide Metabolic Process Canonical Wnt Signaling Pathway Involved In Positive Regulation Of Apoptotic Process Response To Abiotic Stimulus Peptidyl-cysteine S-nitrosylation Collateral Sprouting Axon Midline Choice Point Recognition Cellular Response To Interleukin-3 Regulation Of Binding Smooth Endoplasmic Reticulum Calcium Ion Homeostasis	Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Protein Targeting Positive Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Protein Localization Membrane Organization Intracellular Protein Transport Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Immune System Process Neurotrophin TRK Receptor Signaling Pathway Cellular Protein Localization Neurotrophin Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Catalytic Activity Hippo Signaling Regulation Of Apoptotic Process Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Response To Organic Substance Regulation Of Cell Death Regulation Of Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus
Tagcloud ?		anterior compensatory corticospinal counted densitometry diseased emphasized emphasizes harbor horn horns immunolabeling inclusions lcs lcss mbp myelin oligodendrocyte oligodendrocytes oligodendroglia oligodendroglial p25 p62 perineuronal pnogs presentations proteinopathies suggestive tracts
Tagcloud (Difference) ?		anterior compensatory corticospinal counted densitometry diseased emphasized emphasizes harbor horn horns immunolabeling inclusions lcs lcss mbp myelin oligodendrocyte oligodendrocytes oligodendroglia oligodendroglial p25 p62 perineuronal pnogs presentations proteinopathies suggestive tracts
Tagcloud (Intersection) ?