CDK11B and TH

Number of citations of the paper that reports this interaction (PMID 14675149)
4

Data Source:
HPRD (in vitro, two hybrid)

		CDK11B	TH
Gene Name		cyclin-dependent kinase 11B	tyrosine hydroxylase
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Cytoplasm	Nucleus Cytoplasm Mitochondrion Smooth Endoplasmic Reticulum Cytosol Synaptic Vesicle Cytoplasmic Side Of Plasma Membrane Dendrite Cytoplasmic Vesicle Melanosome Membrane Neuron Projection Terminal Bouton Perikaryon
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Poly(A) RNA Binding	Tyrosine 3-monooxygenase Activity Protein Binding Ferrous Iron Binding Ferric Iron Binding Amino Acid Binding Oxygen Binding Enzyme Binding Protein Domain Specific Binding Tetrahydrobiopterin Binding Dopamine Binding
	Biological Process	Regulation Of Cell Growth Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Mitotic Nuclear Division Cell Proliferation Regulation Of MRNA Processing Regulation Of Cell Cycle	Response To Hypoxia Synaptic Transmission, Dopaminergic Response To Amphetamine Heart Morphogenesis Dopamine Biosynthetic Process From Tyrosine Fatty Acid Metabolic Process Sphingolipid Metabolic Process Heart Development Visual Perception Sensory Perception Of Sound Learning Memory Mating Behavior Locomotory Behavior Regulation Of Heart Contraction Response To Water Deprivation Response To Light Stimulus Response To Herbicide Response To Salt Stress Anatomical Structure Morphogenesis Organ Morphogenesis Response To Zinc Ion Multicellular Organismal Aging Response To Activity Synaptic Vesicle Amine Transport Glycoside Metabolic Process Phthalate Metabolic Process Cerebral Cortex Development Response To Nutrient Levels Response To Estradiol Response To Lipopolysaccharide Isoquinoline Alkaloid Metabolic Process Cellular Nitrogen Compound Metabolic Process Social Behavior Cellular Response To Drug Response To Immobilization Stress Neurotransmitter Biosynthetic Process Terpene Metabolic Process Dopamine Biosynthetic Process Epinephrine Biosynthetic Process Norepinephrine Biosynthetic Process Catecholamine Biosynthetic Process Eye Photoreceptor Cell Development Circadian Sleep/wake Cycle Eating Behavior Response To Peptide Hormone Pigmentation Small Molecule Metabolic Process Response To Ethanol Response To Ether Response To Pyrethroid Embryonic Camera-type Eye Morphogenesis Response To Corticosterone Response To Electrical Stimulus Phytoalexin Metabolic Process Oxidation-reduction Process Cellular Response To Manganese Ion Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus
Pathways		G2/M Transition Centrosome maturation Mitotic G2-G2/M phases Cell Cycle, Mitotic Recruitment of mitotic centrosome proteins and complexes	Amine-derived hormones Catecholamine biosynthesis Metabolism of amino acids and derivatives
Drugs			L-Phenylalanine L-Tyrosine Tetrahydrobiopterin Metyrosine Meta-Tyrosine 7,8-Dihydrobiopterin
Diseases
GWAS			Prostate cancer ( 19767753)
Protein-Protein Interactions		22 interactors: AP2M1 CASP1 CASP3 CASP8 CCND3 CCNL2 EIF3F KAT7 MSN PAK1 PIN1 RANBP9 RPS27A TCEA2 TH TPPP URM1 YWHAB YWHAE YWHAG YWHAQ YWHAZ	12 interactors: CAMK2G CDK11B CSNK2A1 MAPK1 MAPK3 MAPKAPK2 PRKACA RPS6KA5 SNCA TYSND1 YWHAB YWHAZ
Entrez ID		984	7054
HPRD ID		08909	01865
Ensembl ID		ENSG00000248333	ENSG00000180176
Uniprot IDs		P21127	P07101 P78428 Q0PWM2 Q0PWM3
PDB IDs			2XSN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrion Organization Regulation Of Mitochondrion Organization Intrinsic Apoptotic Signaling Pathway Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Apoptotic Process Programmed Cell Death Cell Death Death Positive Regulation Of Apoptotic Signaling Pathway Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Organelle Organization Protein Targeting Positive Regulation Of Intracellular Transport Regulation Of Protein Metabolic Process Cellular Response To Organic Substance Regulation Of Cellular Component Organization Regulation Of Protein Localization Membrane Organization Intracellular Protein Transport Positive Regulation Of Signal Transduction Regulation Of Organelle Organization Immune System Process Neurotrophin TRK Receptor Signaling Pathway Cellular Protein Localization Neurotrophin Signaling Pathway Regulation Of Establishment Of Protein Localization Regulation Of Intracellular Transport Regulation Of Cellular Localization Regulation Of Catalytic Activity Hippo Signaling Regulation Of Apoptotic Process Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Positive Regulation Of Transport Regulation Of Phosphorus Metabolic Process Positive Regulation Of Cellular Protein Metabolic Process Establishment Of Localization In Cell Response To Organic Substance Regulation Of Cell Death Regulation Of Kinase Activity Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Regulation Of Signal Transduction Cellular Response To Growth Factor Stimulus	Phosphorylation Neurotrophin TRK Receptor Signaling Pathway Neurotrophin Signaling Pathway Innate Immune Response Immune Response Phosphate-containing Compound Metabolic Process Vascular Endothelial Growth Factor Receptor Signaling Pathway Regulation Of Cellular Response To Heat Defense Response Apoptotic Process Cellular Response To Growth Factor Stimulus Response To Growth Factor Programmed Cell Death Cell Death Death Epidermal Growth Factor Receptor Signaling Pathway Toll-like Receptor 5 Signaling Pathway ERBB Signaling Pathway Toll-like Receptor 10 Signaling Pathway Response To Cytokine Toll-like Receptor TLR6:TLR2 Signaling Pathway Toll-like Receptor TLR1:TLR2 Signaling Pathway Positive Regulation Of Protein Phosphorylation Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Protein Metabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Fibroblast Growth Factor Stimulus Response To Fibroblast Growth Factor Cellular Response To Heat MyD88-independent Toll-like Receptor Signaling Pathway Regulation Of Cellular Component Organization Toll-like Receptor 3 Signaling Pathway Regulation Of Intracellular Transport Protein Phosphorylation MyD88-dependent Toll-like Receptor Signaling Pathway Positive Regulation Of Protein Kinase Activity MAPK Cascade Positive Regulation Of Phosphorylation Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Kinase Activity Regulation Of Cellular Ketone Metabolic Process Immune System Process Response To Interleukin-1 Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Positive Regulation Of Transferase Activity Activation Of Protein Kinase Activity Signal Transduction By Phosphorylation Toll-like Receptor Signaling Pathway
Tagcloud ?			adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing
Tagcloud (Difference) ?			adrenal avian becomes catecholamine catecholaminergic chromaffin coexpressed coexpression differs embryo galanin ganglia ganglion hydroxylase immunocytochemistry immunoreactivities immunoreactivity intensely neuroactive paravertebral primordia principal repertoire sif somatostatin substances sympathetic sympathoadrenal sympathoblasts synthesizing
Tagcloud (Intersection) ?