AFG3L2 and RAC2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		AFG3L2	RAC2
Gene Name		AFG3-like AAA ATPase 2	ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)
Image
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding Unfolded Protein Binding	GTPase Activity GTP Binding
	Biological Process	Proteolysis Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Death Nerve Development Mitochondrial Protein Processing Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Righting Reflex	Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration
Pathways			Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs		Adenosine triphosphate
Diseases
GWAS			Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		4 interactors: APP MAPK8IP2 PHC2 RAC2	20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4
Entrez ID		10939	5880
HPRD ID		05205	03628
Ensembl ID		ENSG00000141385	ENSG00000128340
Uniprot IDs		Q8TA92 Q9Y4W6	P15153
PDB IDs		2LNA	1DS6 2W2T 2W2V 2W2X
Enriched GO Terms of Interacting Partners?		Mating Behavior Mating Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Sexual Reproduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Learning Dendrite Development Neuron Development Synaptic Growth At Neuromuscular Junction Reproduction Cell Morphogenesis Platelet Activation Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Reproductive Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Nonassociative Learning Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Generation Of Neurons Neurogenesis Neuron Remodeling Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Multicellular Organismal Development Cell Development Blood Coagulation Hemostasis Regulation Of Respiratory Burst Cellular Component Assembly Single-organism Behavior Positive Regulation Of Lamellipodium Assembly Signal Complex Assembly Positive Regulation Of Lamellipodium Organization Axonogenesis Developmental Process Cellular Copper Ion Homeostasis Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Axon Development Nervous System Development Regulation Of Body Fluid Levels	Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development
Tagcloud ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deficiencies deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport	aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Difference) ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport	aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie
Tagcloud (Intersection) ?		deficiencies