AFG3L2 and MAPK8IP2

Number of citations of the paper that reports this interaction (PMID 21900206)
27

Data Source:
BioGRID (two hybrid)

		AFG3L2	MAPK8IP2
Gene Name		AFG3-like AAA ATPase 2	mitogen-activated protein kinase 8 interacting protein 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Mitochondrion Mitochondrial Inner Membrane Integral Component Of Membrane	Cytoplasm Neuronal Cell Body Protein Complex Neuronal Postsynaptic Density
	Molecular Function	Metalloendopeptidase Activity Protein Binding ATP Binding Zinc Ion Binding Unfolded Protein Binding	Beta-amyloid Binding MAP-kinase Scaffold Activity Structural Molecule Activity Protein Binding Kinesin Binding Protein Kinase Binding Protein Kinase Activator Activity Protein Complex Binding
	Biological Process	Proteolysis Axonogenesis Neuromuscular Junction Development Mitochondrial Fusion Death Nerve Development Mitochondrial Protein Processing Regulation Of Multicellular Organism Growth Cristae Formation Myelination Muscle Fiber Development Righting Reflex	MAPK Cascade Behavioral Fear Response Signal Complex Assembly JNK Cascade Mating Behavior Regulation Of Receptor Activity Positive Regulation Of Stress-activated MAPK Cascade Social Behavior Positive Regulation Of Protein Kinase Activity Regulation Of JNK Cascade Nonassociative Learning Dendrite Morphogenesis Regulation Of Synaptic Transmission, Glutamatergic Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of N-methyl-D-aspartate Selective Glutamate Receptor Activity Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity
Pathways
Drugs		Adenosine triphosphate
Diseases
GWAS
Protein-Protein Interactions		4 interactors: APP MAPK8IP2 PHC2 RAC2	52 interactors: ADRB2 AFG3L2 APP ASRGL1 BBS10 C14orf1 CFL1 CHN1 CRMP1 DUSP16 EGFR ERBB2 EZH2 FGF12 FSCN1 GBP2 ITSN1 KIFC2 KLC1 LRP1 LRP2 LRP8 MAGED4B MAP2K3 MAP2K7 MAP3K10 MAP3K11 MAP3K12 MAPK10 MAPK8 MAPK8IP1 MAPK8IP3 MAPK9 MASP1 NDUFS6 PLXNA3 PRSS23 RAI1 RBX1 RPS6KB2 SMARCB1 SMS SYNE2 TIAM1 TP53BP2 UNC119 VCP VPS33B VRK2 YY1AP1 ZNF593 ZNF784
Entrez ID		10939	23542
HPRD ID		05205	09674
Ensembl ID		ENSG00000141385	ENSG00000008735
Uniprot IDs		Q8TA92 Q9Y4W6	Q13387
PDB IDs		2LNA
Enriched GO Terms of Interacting Partners?		Mating Behavior Mating Cell Morphogenesis Involved In Neuron Differentiation Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Regulation Of Receptor Activity Sexual Reproduction Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Learning Dendrite Development Neuron Development Synaptic Growth At Neuromuscular Junction Reproduction Cell Morphogenesis Platelet Activation Neuron Differentiation Cell Projection Organization Collateral Sprouting In Absence Of Injury Reproductive Process Learning Or Memory Collateral Sprouting Axon Midline Choice Point Recognition Nonassociative Learning Cognition Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Axon Choice Point Recognition Generation Of Neurons Neurogenesis Neuron Remodeling Axon Guidance Regulation Of Hydrogen Peroxide Metabolic Process Multicellular Organismal Development Cell Development Blood Coagulation Hemostasis Regulation Of Respiratory Burst Cellular Component Assembly Single-organism Behavior Positive Regulation Of Lamellipodium Assembly Signal Complex Assembly Positive Regulation Of Lamellipodium Organization Axonogenesis Developmental Process Cellular Copper Ion Homeostasis Regulation Of Alpha-amino-3-hydroxy-5-methyl-4-isoxazole Propionate Selective Glutamate Receptor Activity Axon Development Nervous System Development Regulation Of Body Fluid Levels	Stress-activated MAPK Cascade Stress-activated Protein Kinase Signaling Cascade JNK Cascade Signal Transduction By Phosphorylation MAPK Cascade Regulation Of Protein Kinase Activity Regulation Of MAPK Cascade Regulation Of Kinase Activity Regulation Of Phosphorylation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Catalytic Activity Positive Regulation Of Kinase Activity JUN Phosphorylation Regulation Of MAP Kinase Activity Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Protein Metabolic Process Regulation Of Phosphorus Metabolic Process Regulation Of Catalytic Activity Positive Regulation Of Transferase Activity Positive Regulation Of Phosphorylation Positive Regulation Of Protein Phosphorylation Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Modification Process Positive Regulation Of Signal Transduction Positive Regulation Of MAP Kinase Activity Response To Stress Regulation Of Protein Metabolic Process Regulation Of Cellular Protein Metabolic Process Positive Regulation Of MAPK Cascade Regulation Of Signal Transduction Response To Light Stimulus Response To External Stimulus Response To Radiation Regulation Of Signaling Intracellular Signal Transduction Activation Of Protein Kinase Activity Positive Regulation Of Protein Serine/threonine Kinase Activity Axon Guidance Regulation Of Intracellular Signal Transduction Signal Transduction Axonogenesis Phosphorylation Cell Part Morphogenesis Axon Development Response To Stimulus Cell Morphogenesis Involved In Neuron Differentiation Response To Abiotic Stimulus Protein Phosphorylation Cellular Response To Stress Signaling
Tagcloud ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deficiencies deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport
Tagcloud (Difference) ?		acetylcysteine anterograde antioxidants ataxia axonal axons consistently cytoskeletal deficiencies deleted depleted dynamin fragmentation gtpase hyperphosphorylation impair inner mitochondrial neurodegeneration neurons observe oma1 opa1 postnatally restored sca28 spinocerebellar transport
Tagcloud (Intersection) ?