RAC2 and ADAM22

Number of citations of the paper that reports this interaction (PMID 21988832)
14

Data Source:
BioGRID (two hybrid)

		RAC2	ADAM22
Gene Name		ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)	ADAM metallopeptidase domain 22
Image
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Cytosol Actin Filament Plasma Membrane Focal Adhesion Lamellipodium Extracellular Vesicular Exosome	Integral Component Of Membrane Axon
	Molecular Function	GTPase Activity GTP Binding	Metalloendopeptidase Activity Integrin Binding Protein Binding Zinc Ion Binding
	Biological Process	Actin Filament Organization Signal Transduction G-protein Coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Axon Guidance Blood Coagulation Positive Regulation Of Cell Proliferation Regulation Of Hydrogen Peroxide Metabolic Process Positive Regulation Of Lamellipodium Assembly Regulation Of Cell-substrate Adhesion Cell Projection Assembly Platelet Activation Bone Resorption Regulation Of Small GTPase Mediated Signal Transduction Regulation Of Respiratory Burst Lymphocyte Aggregation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Neutrophil Migration	Proteolysis Cell Adhesion Negative Regulation Of Cell Adhesion Central Nervous System Development Adult Locomotory Behavior Myelination In Peripheral Nervous System
Pathways		Signaling by GPCR Axon guidance Semaphorin interactions Signaling by Wnt beta-catenin independent WNT signaling Rho GTPase cycle GPCR downstream signaling Signaling by Rho GTPases GPVI-mediated activation cascade G alpha (12/13) signalling events Sema4D in semaphorin signaling Platelet activation, signaling and aggregation PCP/CE pathway Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Graves' disease ( 23612905) Longevity ( 20834067)
Protein-Protein Interactions		20 interactors: ACTB ADAM22 AFG3L2 ARFIP2 ARHGDIA ARHGDIB CDC42 CHGB CUL1 DEF6 DOCK2 GDI1 ICMT NCF2 NOS2 NOXA1 PAK2 RTKN SMAD1 SMAD4	5 interactors: EPS8 LGI1 RAC2 YWHAB YWHAZ
Entrez ID		5880	53616
HPRD ID		03628	04751
Ensembl ID		ENSG00000128340	ENSG00000008277
Uniprot IDs		P15153	Q08AL8 Q9P0K1
PDB IDs		1DS6 2W2T 2W2V 2W2X	3G5C
Enriched GO Terms of Interacting Partners?		Intracellular Signal Transduction Small GTPase Mediated Signal Transduction Developmental Process Multicellular Organismal Development Positive Regulation Of Catalytic Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurogenesis Signal Transduction Immune Response Enzyme Linked Receptor Protein Signaling Pathway Regulation Of Catalytic Activity Response To External Stimulus Superoxide Metabolic Process Signaling Positive Regulation Of Cell Morphogenesis Involved In Differentiation Cell Communication Anatomical Structure Development Response To Stimulus System Development Cell Differentiation Positive Regulation Of Metabolic Process Generation Of Neurons Rho Protein Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Ras Protein Signal Transduction Nervous System Development Regulation Of Cell Morphogenesis Innate Immune Response Midbrain Development SMAD Protein Complex Assembly Cellular Response To Stimulus Axonogenesis Defense Response Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Movement Of Cell Or Subcellular Component Reactive Oxygen Species Metabolic Process Regulation Of Cell Adhesion Neuron Projection Morphogenesis Immune System Process Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Defense Response To Virus By Virus Cell Projection Organization Cell Morphogenesis Involved In Differentiation Axon Guidance Regulation Of Protein Catabolic Process Regulation Of Signaling Regulation Of Protein Localization Cell Development	Cellular Component Assembly Regulation Of Cellular Component Organization Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Locomotion Regulation Of Signaling Axon Guidance Positive Regulation Of Mitochondrion Organization Movement Of Cell Or Subcellular Component Axonogenesis Axon Development Cell Morphogenesis Involved In Neuron Differentiation Regulation Of Mitochondrion Organization Chemotaxis Small GTPase Mediated Signal Transduction Intracellular Signal Transduction Neuron Projection Morphogenesis Cell Morphogenesis Involved In Differentiation Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Organelle Organization Actin Polymerization-dependent Cell Motility Intrinsic Apoptotic Signaling Pathway Neuron Development Platelet Activation Positive Regulation Of Apoptotic Signaling Pathway Golgi Reassembly Ras Protein Signal Transduction Cell Morphogenesis Regulation Of Signal Transduction Positive Regulation Of Intracellular Transport Neuron Differentiation Cell Projection Organization Negative Regulation Of Protein Dephosphorylation Histamine Secretion By Mast Cell Establishment Of Golgi Localization Exit From Mitosis Positive Regulation Of Signal Transduction Golgi Inheritance Actin Filament Organization Behavioral Response To Ethanol Histamine Secretion Apoptotic Signaling Pathway Regulation Of Hydrogen Peroxide Metabolic Process Regulation Of Respiratory Burst Histamine Transport
Tagcloud ?		aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie	4pba abnormally adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure
Tagcloud (Difference) ?		aldrich basket caenorhabditis ced cg32138 collaborate crossvein decapentaplegic deficiencies dominantly draper drpr engulfment enhancers formin hemipterous hippo melanogaster modifiers myoblast pruning puckered rac1 rhoa salvador suppressors wing wiskcott yorkie	4pba abnormally adlte ameliorated autosomal competent compromising conformational converging corrector defective degraded dimerized e383a epilepsy establishes folding intractable lgi1 lobe machinery missense options phenylbutyrate prematurely representative s473l secretable seizure
Tagcloud (Intersection) ?