ATG7 and IRF2

Number of citations of the paper that reports this interaction (PMID 21903422)
33

Data Source:
BioGRID (affinity chromatography technology, pull down)

		ATG7	IRF2
Gene Name		autophagy related 7	interferon regulatory factor 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasm Cytosol Axoneme	Nucleoplasm Cytoplasm Cytosol Focal Adhesion
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding
	Biological Process	Mitochondrion Degradation Liver Development Cellular Protein Modification Process Protein Lipidation C-terminal Protein Lipidation Cellular Amino Acid Metabolic Process Cellular Response To Nitrogen Starvation Mitochondrion Organization Adult Walking Behavior Cellular Response To Starvation Post-embryonic Development Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Macroautophagy Protein Ubiquitination Cerebellar Purkinje Cell Layer Development Pyramidal Neuron Development Central Nervous System Neuron Axonogenesis Cerebral Cortex Development Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of Nucleus Negative Stranded Viral RNA Replication Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Late Nucleophagy Positive Regulation Of Protein Catabolic Process Neurological System Process Cardiac Muscle Cell Development Membrane Fusion Positive Regulation Of Mucus Secretion Cellular Response To Hyperoxia Negative Regulation Of Histone H4-K16 Acetylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B	22 interactors: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 FOXK2 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA STAT1
Entrez ID		10533	3660
HPRD ID		12293	00962
Ensembl ID		ENSG00000197548	ENSG00000168310
Uniprot IDs		O95352	P14316
PDB IDs
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Autophagy Vacuole Organization Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Membrane Fusion Response To Stress Cellular Response To Stress Cell Communication Catabolic Process Response To External Stimulus Cellular Component Assembly Cellular Response To Stimulus Membrane Organization Response To Stimulus Cellular Metabolic Process Autophagy In Response To ER Overload Organelle Organization Synaptic Growth At Neuromuscular Junction Protein Lipidation Lipoprotein Biosynthetic Process Collateral Sprouting In Absence Of Injury Protein Transport Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Protein Localization Lipoprotein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Transport Axon Choice Point Recognition Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Neuron Remodeling ER Overload Response Metabolic Process Protein Localization Apoptotic Process Establishment Of Localization In Cell Programmed Cell Death	Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Immune Response Negative Regulation Of Biosynthetic Process Defense Response Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Response To External Stimulus Biosynthetic Process Cell Death Death Regulation Of Interleukin-12 Production Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Viral Process
Tagcloud ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Difference) ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2
Tagcloud (Intersection) ?