IRF2 and IRF2BP2

Number of citations of the paper that reports this interaction (PMID 12799427)
18

Data Source:
HPRD (two hybrid, in vivo)

		IRF2	IRF2BP2
Gene Name		interferon regulatory factor 2	interferon regulatory factor 2 binding protein 2
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Focal Adhesion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription, DNA-templated
Pathways		Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS			Bipolar disorder ( 22688191) Cholesterol, total ( 20686565) LDL cholesterol ( 20686565) Life threatening arrhythmia ( 22247754)
Protein-Protein Interactions		22 interactors: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 FOXK2 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA STAT1	2 interactors: IRF2 NFATC2
Entrez ID		3660	359948
HPRD ID		00962	17160
Ensembl ID		ENSG00000168310	ENSG00000168264
Uniprot IDs		P14316	Q7Z5L9
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Immune Response Negative Regulation Of Biosynthetic Process Defense Response Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Response To External Stimulus Biosynthetic Process Cell Death Death Regulation Of Interleukin-12 Production Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Viral Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription From RNA Polymerase II Promoter Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Immune Response Negative Regulation Of Gene Expression Positive Regulation Of Transcription, DNA-templated Defense Response B Cell Receptor Signaling Pathway Negative Regulation Of Biosynthetic Process Positive Regulation Of B Cell Proliferation Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Regulation Of B Cell Proliferation Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of B Cell Activation Negative Regulation Of Cellular Metabolic Process Immune System Process Type I Interferon Signaling Pathway Cellular Response To Type I Interferon Response To Type I Interferon Transcription, DNA-templated Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation RNA Biosynthetic Process Interferon-gamma-mediated Signaling Pathway Antigen Receptor-mediated Signaling Pathway Cytokine Production Positive Regulation Of Cellular Metabolic Process Cellular Response To Interferon-gamma Response To Interferon-gamma Cell Surface Receptor Signaling Pathway RNA Metabolic Process Fc-epsilon Receptor Signaling Pathway Positive Regulation Of Metabolic Process Response To Stress Gene Expression Fc Receptor Signaling Pathway Cellular Macromolecule Biosynthetic Process Immune Response-activating Cell Surface Receptor Signaling Pathway Macromolecule Biosynthetic Process Positive Regulation Of Cell Activation
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	apl arsenic breakpoints consolidation cytogenetics ecchymoses epistaxis exon expands fusion gemtuzumab immunophenotypic intron list morphologic next oligonucleotide ozogamicin partners pml presents promyelocytic rara rarely relapsed remission sequencing translocations woman
Tagcloud (Intersection) ?