IRF2 and BRD7

Number of citations of the paper that reports this interaction (PMID 11025449)
8

Data Source:
BioGRID (two hybrid, pull down)

		IRF2	BRD7
Gene Name		interferon regulatory factor 2	bromodomain containing 7
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Focal Adhesion	Nucleus Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Sequence-specific DNA Binding Transcription Factor Activity Protein Binding	P53 Binding Transcription Coactivator Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Histone Binding Transcription Regulatory Region DNA Binding Lysine-acetylated Histone Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Transcription, DNA-templated Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Cytokine-mediated Signaling Pathway Positive Regulation Of Transcription From RNA Polymerase II Promoter Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter Cell Cycle Negative Regulation Of Cell Proliferation Wnt Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Interferon gamma signaling RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Interferon Signaling TRAF6 mediated IRF7 activation Cytokine Signaling in Immune system Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		22 interactors: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 FOXK2 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA STAT1	27 interactors: AGR2 BARD1 BHLHE40 BRD3 BTBD2 DVL1 FTH1 HAP1 HIST1H2AL HIST2H2BE HIST2H3C HIST3H3 HIST4H4 HNRNPUL1 IRF2 LAMA4 LRIF1 NEFL PAFAH1B3 PCBD1 PSMD11 PTPN13 RBFOX2 RIF1 RPLP1 SERPINB9 TRIM24
Entrez ID		3660	29117
HPRD ID		00962	12531
Ensembl ID		ENSG00000168310	ENSG00000166164
Uniprot IDs		P14316	Q9NPI1
PDB IDs			2I7K
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Cellular Metabolic Process Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Innate Immune Response Regulation Of Gene Expression RNA Biosynthetic Process RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Regulation Of Metabolic Process Transcription, DNA-templated Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Gene Expression Cellular Nitrogen Compound Metabolic Process Immune Response Negative Regulation Of Biosynthetic Process Defense Response Cellular Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Transcription, DNA-templated Response To Abiotic Stimulus Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Macromolecule Biosynthetic Process Transcription From RNA Polymerase II Promoter Macromolecule Biosynthetic Process Negative Regulation Of Gene Expression Regulation Of Interleukin-12 Biosynthetic Process Regulation Of Protein Metabolic Process Apoptotic Process Programmed Cell Death Response To External Stimulus Biosynthetic Process Cell Death Death Regulation Of Interleukin-12 Production Cellular Response To Peptide Hormone Stimulus Cellular Response To Peptide Viral Process	Gene Expression Cellular Nitrogen Compound Metabolic Process Nucleobase-containing Compound Metabolic Process Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Nitrogen Compound Metabolic Process Negative Regulation Of Cellular Metabolic Process RNA Biosynthetic Process Regulation Of Nitrogen Compound Metabolic Process RNA Metabolic Process Regulation Of RNA Metabolic Process Retrograde Axon Cargo Transport Transcription, DNA-templated Telomere Maintenance DNA Methylation On Cytosine DNA Modification Chromatin Silencing At RDNA Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Regulation Of Gene Expression Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of Gene Expression Neuromuscular Process Negative Regulation Of Biosynthetic Process Anterograde Axon Cargo Transport Cellular Response To Estrogen Stimulus Chromatin Silencing Cellular Macromolecule Biosynthetic Process Macromolecule Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Neurotrophin Production Positive Regulation Of Nonmotile Primary Cilium Assembly Regulation Of Metabolic Process Axon Cargo Transport Regulation Of Gene Expression, Epigenetic Positive Regulation Of Protein Catabolic Process DNA Methylation Demethylation Mucus Secretion Intracellular Sequestering Of Iron Ion Negative Regulation Of MRNA 3'-end Processing Negative Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Homeostatic Process Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Cell Projection Organization Neuromuscular Process Controlling Balance Convergent Extension Involved In Neural Plate Elongation
Tagcloud ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified
Tagcloud (Difference) ?		artp calculating chief convergence dusp2 hrgg il2ra il6 il8ra il8rb infgr1 map3k10 merits mmp1 nfkb1a nos2a partp pik3ca polygenic pttrnd raf1 rectal runx3 sepx1 smad3 soc strongest truncation tyk2	aza clinically cofactor dc demethylating disturbing ectopic endogenous finding glioma gliomas hypermethylation implicated inactivated inactivation intracranial lrrc4 magnetic microrna mir negatively pathological researches resonance restoration silencing transcriptional transplanted verified
Tagcloud (Intersection) ?