ATG7 and ATG12

Number of citations of the paper that reports this interaction (PMID 12482611)
10

Data Source:
HPRD (two hybrid, in vivo)

		ATG7	ATG12
Gene Name		autophagy related 7	autophagy related 12
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Pre-autophagosomal Structure Cytoplasm Cytosol Axoneme	Pre-autophagosomal Structure Membrane Atg12-Atg5-Atg16 Complex
	Molecular Function	Ubiquitin Activating Enzyme Activity Protein Binding Transcription Factor Binding Atg12 Activating Enzyme Activity Atg8 Activating Enzyme Activity Protein Homodimerization Activity	Protein Binding Atg8 Ligase Activity
	Biological Process	Mitochondrion Degradation Liver Development Cellular Protein Modification Process Protein Lipidation C-terminal Protein Lipidation Cellular Amino Acid Metabolic Process Cellular Response To Nitrogen Starvation Mitochondrion Organization Adult Walking Behavior Cellular Response To Starvation Post-embryonic Development Positive Regulation Of Autophagy Protein Transport Positive Regulation Of Macroautophagy Protein Ubiquitination Cerebellar Purkinje Cell Layer Development Pyramidal Neuron Development Central Nervous System Neuron Axonogenesis Cerebral Cortex Development Protein Catabolic Process Regulation Of Protein Ubiquitination Positive Regulation Of Protein Modification Process Protein Modification By Small Protein Conjugation Piecemeal Microautophagy Of Nucleus Negative Stranded Viral RNA Replication Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Late Nucleophagy Positive Regulation Of Protein Catabolic Process Neurological System Process Cardiac Muscle Cell Development Membrane Fusion Positive Regulation Of Mucus Secretion Cellular Response To Hyperoxia Negative Regulation Of Histone H4-K16 Acetylation	Autophagic Vacuole Assembly Mitochondrion Degradation C-terminal Protein Lipidation Cellular Response To Nitrogen Starvation Negative Regulation Of Type I Interferon Production Nucleophagy Innate Immune Response
Pathways		Antigen processing: Ubiquitination & Proteasome degradation Class I MHC mediated antigen processing & presentation Adaptive Immune System	RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways Negative regulators of RIG-I/MDA5 signaling Innate Immune System
Drugs
Diseases
GWAS
Protein-Protein Interactions		10 interactors: APP ATG10 ATG12 ATG3 EEF1D GABARAP GABARAPL2 IRF2 MAP1LC3A MAP1LC3B	10 interactors: APP ATG10 ATG3 ATG5 ATG7 CRX KRTAP4-12 MDFI PLSCR1 PTK2
Entrez ID		10533	9140
HPRD ID		12293	08496
Ensembl ID		ENSG00000197548	ENSG00000145782
Uniprot IDs		O95352	O94817
PDB IDs			4GDK 4GDL
Enriched GO Terms of Interacting Partners?		Nucleophagy Mitochondrion Degradation Organelle Disassembly Autophagic Vacuole Assembly Macroautophagy Autophagy Vacuole Organization Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cellular Response To Nutrient Levels Response To Starvation Cellular Response To Extracellular Stimulus Mitochondrion Organization Response To Nutrient Levels Response To Extracellular Stimulus Organelle Assembly Membrane Fusion Response To Stress Cellular Response To Stress Cell Communication Catabolic Process Response To External Stimulus Cellular Component Assembly Cellular Response To Stimulus Membrane Organization Response To Stimulus Cellular Metabolic Process Autophagy In Response To ER Overload Organelle Organization Synaptic Growth At Neuromuscular Junction Protein Lipidation Lipoprotein Biosynthetic Process Collateral Sprouting In Absence Of Injury Protein Transport Collateral Sprouting Axon Midline Choice Point Recognition Establishment Of Protein Localization Lipoprotein Metabolic Process Smooth Endoplasmic Reticulum Calcium Ion Homeostasis Intracellular Transport Axon Choice Point Recognition Mitochondrial Fragmentation Involved In Apoptotic Process Innate Immune Response Neuron Remodeling ER Overload Response Metabolic Process Protein Localization Apoptotic Process Establishment Of Localization In Cell Programmed Cell Death	Nucleophagy Negative Regulation Of Histone H4-K16 Acetylation Mitochondrion Degradation Autophagy Organelle Disassembly Negative Regulation Of Histone H4 Acetylation Response To Stress Negative Stranded Viral RNA Replication Positive Regulation Of Cellular Metabolic Process Protein Lipidation Positive Regulation Of Mucus Secretion Regulation Of Histone H4 Acetylation Lipoprotein Biosynthetic Process Regulation Of Mucus Secretion Apoptotic Process Response To External Stimulus Negative Regulation Of Histone Acetylation Programmed Cell Death Cellular Response To Starvation Cellular Response To Nitrogen Starvation Cell Death Negative Regulation Of Peptidyl-lysine Acetylation Death Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Protein Acetylation Positive Regulation Of Cellular Protein Metabolic Process Viral Genome Replication Regulation Of Cilium Assembly Lipoprotein Metabolic Process Response To Starvation Positive Regulation Of Metabolic Process Cellular Response To Nutrient Levels Positive Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Protein Ubiquitination Platelet Activation C-terminal Protein Lipidation Cellular Response To Extracellular Stimulus Response To Stimulus Cellular Response To Stress Autophagic Vacuole Assembly Regulation Of Histone Acetylation Central Nervous System Neuron Axonogenesis Macroautophagy Positive Regulation Of Protein Modification Process Regulation Of Organelle Organization Organ Development Cardiac Muscle Cell Development Mitochondrion Organization Regulation Of Cellular Amino Acid Metabolic Process
Tagcloud ?		a1 annexin autophagosome autophagy baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	akt1 antipsychotic atg4b atg5 atg7 autophagic autophagosome autophagosomes autophagy bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Difference) ?		a1 annexin baf bafilomycin beclin bioactive classical clear crocin cytometric enhancement g1 g2 gammah2ax hct116 inefficient lc3 mild nonfunctional p62 predicting pretreatment programmed saffron sensor treating wild	akt1 antipsychotic atg4b atg5 autophagic autophagosomes bak1 bcl2l11 becn1 cdkn1a cdkn1b chloroquine colocalization dysfunctional gabarap henceforth lc3b map1lc3b olanzapine overtly pmaip1 sqstm1 sy5y trp53 unmask
Tagcloud (Intersection) ?		atg7 autophagosome autophagy