SIGMAR1 and ITPR3

Number of citations of the paper that reports this interaction (PMID 11149946)
50

Data Source:
HPRD (in vivo, in vitro)

		SIGMAR1	ITPR3
Gene Name		sigma non-opioid intracellular receptor 1	inositol 1,4,5-trisphosphate receptor, type 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Endoplasmic Reticulum Membrane Lipid Particle Integral Component Of Plasma Membrane Integral Component Of Membrane Cell Junction Growth Cone	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell
	Molecular Function	Opioid Receptor Activity Drug Binding	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Lipid Transport Nervous System Development Opioid Receptor Signaling Pathway Regulation Of Neuron Apoptotic Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport
Pathways			Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs		Dextromethorphan Naltrexone
Diseases
GWAS			Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)
Protein-Protein Interactions		3 interactors: ANK2 ITPR3 PDZD11	13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2
Entrez ID		10280	3710
HPRD ID		03580	00926
Ensembl ID		ENSG00000147955	ENSG00000096433
Uniprot IDs		A2A3U5 B4DR71 Q99720	A6H8K3 Q14573 Q59ES2
PDB IDs
Enriched GO Terms of Interacting Partners?		Second-messenger-mediated Signaling Protein Localization To Plasma Membrane Protein Localization To T-tubule Protein Localization To M-band T-tubule Organization Plasma Membrane Organization Ion Transport Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Calcium Ion Transport Protein Localization To Basolateral Plasma Membrane Membrane Depolarization During SA Node Cell Action Potential Establishment Of Localization In Cell SA Node Cell Action Potential Maintenance Of Epithelial Cell Apical/basal Polarity Sensory Perception Of Sweet Taste Protein Localization To Membrane Maintenance Of Apical/basal Cell Polarity Sensory Perception Of Umami Taste Cellular Metal Ion Homeostasis Regulation Of Cardiac Muscle Cell Membrane Potential Endomembrane System Organization Atrial Cardiac Muscle Cell Action Potential SA Node Cell To Atrial Cardiac Muscle Cell Communication Atrial Cardiac Muscle Cell To AV Node Cell Communication Cellular Cation Homeostasis Cellular Ion Homeostasis Cellular Localization Response To Methylmercury Metal Ion Homeostasis Sarcoplasmic Reticulum Calcium Ion Transport Positive Regulation Of Potassium Ion Transmembrane Transporter Activity Pantothenate Metabolic Process Maintenance Of Cell Polarity Biotin Metabolic Process Cellular Chemical Homeostasis Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization Ion Homeostasis Cell-cell Signaling Involved In Cardiac Conduction Positive Regulation Of Potassium Ion Transmembrane Transport Paranodal Junction Assembly Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Inositol Phosphate-mediated Signaling Protein Localization To Cell Surface Ventricular Cardiac Muscle Cell Action Potential Cellular Homeostasis Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Atrial Septum Development Regulation Of Heart Rate By Cardiac Conduction	Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation
Tagcloud ?		became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring hela huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged	anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Difference) ?		became chaperones chronologically cytoplasm degrades epoxomicin exportin harboring hela huntingtin huntington inclusion inclusions insolubilized lc3 leptomycin machinery misfolded ni nis nucleus p62 participate polyglutamine proteasome shuttle sirna unchanged	anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually
Tagcloud (Intersection) ?