ITPR3 and TRPC2

Number of citations of the paper that reports this interaction (PMID 11290752)
57

Data Source:
BioGRID (pull down)

		ITPR3	TRPC2
Gene Name		inositol 1,4,5-trisphosphate receptor, type 3	transient receptor potential cation channel, subfamily C, member 2, pseudogene
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell
	Molecular Function	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization
Drugs
Diseases
GWAS		Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)
Protein-Protein Interactions		13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	1 interactors: ITPR3
Entrez ID		3710	7221
HPRD ID		00926
Ensembl ID		ENSG00000096433	ENSG00000182048
Uniprot IDs		A6H8K3 Q14573 Q59ES2
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation	Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Inositol Phosphate-mediated Signaling Sensory Perception Of Bitter Taste Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Activation Of Phospholipase C Activity Long-term Synaptic Potentiation Positive Regulation Of Phospholipase C Activity Sensory Perception Of Taste Positive Regulation Of Phospholipase Activity Regulation Of Phospholipase Activity Positive Regulation Of Lipase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission Response To Calcium Ion Memory Protein Heterooligomerization Energy Reserve Metabolic Process Second-messenger-mediated Signaling Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Cytosolic Calcium Ion Concentration Fc-gamma Receptor Signaling Pathway Fc Receptor Mediated Stimulatory Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Regulation Of Synaptic Plasticity Cytosolic Calcium Ion Homeostasis Cellular Response To Fibroblast Growth Factor Stimulus Platelet Activation Response To Fibroblast Growth Factor Regulation Of Insulin Secretion Neurotrophin TRK Receptor Signaling Pathway Calcium Ion Transmembrane Transport Regulation Of Peptide Hormone Secretion Neurotrophin Signaling Pathway Fc-epsilon Receptor Signaling Pathway Protein Homooligomerization Phagocytosis Regulation Of Hormone Secretion Learning Or Memory Fc Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Cognition Cellular Calcium Ion Homeostasis Energy Derivation By Oxidation Of Organic Compounds Calcium Ion Homeostasis Regulation Of Synaptic Transmission Calcium Ion Transport
Tagcloud ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc1 trpc1a trpl
Tagcloud (Difference) ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	ca2 cation cdna channels converted dami details entry excitable hel homologues htrp1 identity influx meg01 megakaryocytes megakaryocytic platelets primers producers revealing sizes splicing store trpc1 trpc1a trpl
Tagcloud (Intersection) ?