ITPR3 and TRPC3

Number of citations of the paper that reports this interaction (PMID 11524429)
23

Data Source:
HPRD (in vivo)

		ITPR3	TRPC3
Gene Name		inositol 1,4,5-trisphosphate receptor, type 3	transient receptor potential cation channel, subfamily C, member 3
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Plasma Membrane Integral Component Of Plasma Membrane Brush Border Membrane Platelet Dense Tubular Network Membrane Neuronal Cell Body Myelin Sheath Receptor Complex Apical Part Of Cell	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Inositol Hexakisphosphate Binding Intracellular Ligand-gated Calcium Channel Activity Inositol 1,4,5-trisphosphate-sensitive Calcium-release Channel Activity Protein Binding Phosphatidylinositol Binding Inositol 1,3,4,5 Tetrakisphosphate Binding Inositol 1,4,5 Trisphosphate Binding	Calcium Channel Activity Protein Binding Store-operated Calcium Channel Activity Inositol 1,4,5 Trisphosphate Binding
	Biological Process	Energy Reserve Metabolic Process Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Coagulation Memory Fibroblast Growth Factor Receptor Signaling Pathway Platelet Activation Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Small Molecule Metabolic Process Innate Immune Response Vascular Endothelial Growth Factor Receptor Signaling Pathway Neurotrophin TRK Receptor Signaling Pathway Inositol Phosphate-mediated Signaling Regulation Of Insulin Secretion Sensory Perception Of Bitter Taste Sensory Perception Of Sweet Taste Sensory Perception Of Umami Taste Protein Homooligomerization Protein Heterooligomerization Response To Calcium Ion Long-term Synaptic Potentiation Calcium Ion Transport Into Cytosol Calcium Ion Transmembrane Transport	Calcium Ion Transport Axon Guidance Blood Coagulation Phototransduction Positive Regulation Of Calcium Ion Transport Into Cytosol Platelet Activation Response To ATP Ion Transmembrane Transport Response To Calcium Ion Transmembrane Transport Calcium Ion Transmembrane Transport Positive Regulation Of Cardiac Muscle Hypertrophy In Response To Stress
Pathways		Signaling by the B Cell Receptor (BCR) Signaling by GPCR Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Signaling by FGFR in disease Phospholipase C-mediated cascade Integration of energy metabolism Signaling by Wnt Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling Effects of PIP2 hydrolysis Platelet calcium homeostasis DAP12 signaling Gastrin-CREB signalling pathway via PKC and MAPK Role of phospholipids in phagocytosis Fcgamma receptor (FCGR) dependent phagocytosis Signaling by PDGF DAP12 interactions Opioid Signalling EGFR interacts with phospholipase C-gamma Signaling by ERBB2 G alpha (q) signalling events Signaling by EGFR GPCR downstream signaling Platelet homeostasis Signaling by VEGF Downstream signal transduction Fc epsilon receptor (FCERI) signaling Signaling by EGFR in Cancer Platelet activation, signaling and aggregation Adaptive Immune System G alpha (q) signalling events DAG and IP3 signaling VEGFA-VEGFR2 Pathway VEGFR2 mediated cell proliferation Downstream signaling of activated FGFR Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Innate Immune System Signalling by NGF PLC beta mediated events Regulation of insulin secretion Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR beta-catenin independent WNT signaling Ca2+ pathway Elevation of cytosolic Ca2+ levels PLC-gamma1 signalling FCERI mediated Ca+2 mobilization	G alpha (q) signalling events Signaling by GPCR Axon guidance TRP channels Effects of PIP2 hydrolysis Platelet calcium homeostasis G alpha (q) signalling events GPCR downstream signaling Ion channel transport Platelet homeostasis Role of second messengers in netrin-1 signaling Gastrin-CREB signalling pathway via PKC and MAPK Elevation of cytosolic Ca2+ levels Stimuli-sensing channels Platelet activation, signaling and aggregation Netrin-1 signaling
Drugs
Diseases
GWAS		Educational attainment ( 23722424) Obesity (extreme) ( 19553259) Phosphorus levels ( 20558539)
Protein-Protein Interactions		13 interactors: AKT1 ANK1 CABP1 ITPR1 SIGMAR1 TRPC1 TRPC2 TRPC3 TRPC4 TRPC5 TRPC6 TRPC7 TRPM2	20 interactors: CALM1 FKBP1A GNA11 ITPR1 ITPR3 MX1 NAPA ORAI1 PLCB1 PLCB2 PLCB3 PLCG1 PRKCA PRKG1 SLC8A1 STX3 TRPC1 TRPC6 TRPC7 VAMP2
Entrez ID		3710	7222
HPRD ID		00926	15999
Ensembl ID		ENSG00000096433	ENSG00000138741
Uniprot IDs		A6H8K3 Q14573 Q59ES2	J3QTB0 Q13507
PDB IDs
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Transport Calcium Ion Transport Axon Guidance Cation Transport Metal Ion Transport Axonogenesis Cation Transmembrane Transport Axon Development Cell Morphogenesis Involved In Neuron Differentiation Chemotaxis Neuron Projection Morphogenesis Ion Transport Cell Projection Organization Cell Morphogenesis Involved In Differentiation Platelet Activation Ion Transmembrane Transport Neuron Projection Development Cell Projection Morphogenesis Cell Part Morphogenesis Neuron Development Nervous System Development Generation Of Neurons Regulation Of Body Fluid Levels Neurogenesis Cell Morphogenesis Transmembrane Transport Neuron Differentiation Transport Cell Development Response To External Stimulus Locomotion Blood Coagulation Hemostasis Regulation Of Calcium Ion Transport Positive Regulation Of Ion Transport Movement Of Cell Or Subcellular Component Multicellular Organismal Development Wound Healing Regulation Of Ion Transport Manganese Ion Transmembrane Transport Positive Regulation Of Calcium Ion Transport Manganese Ion Transport Cell Activation Response To Wounding Developmental Process System Development Chemical Homeostasis Response To Oxidative Stress Regulation Of Intracellular Transport Cell Differentiation	Regulation Of Body Fluid Levels Blood Coagulation Hemostasis Wound Healing Response To Wounding Activation Of Phospholipase C Activity Calcium Ion Transmembrane Transport Positive Regulation Of Phospholipase C Activity Positive Regulation Of Phospholipase Activity Cell Activation Regulation Of Phospholipase Activity Calcium Ion Transport Positive Regulation Of Lipase Activity Regulation Of Cellular Localization Regulation Of Calcium Ion Transport Platelet Activation Inositol Phosphate Metabolic Process Second-messenger-mediated Signaling Cellular Calcium Ion Homeostasis Regulation Of Ion Homeostasis Calcium Ion Homeostasis Cytosolic Calcium Ion Homeostasis Positive Regulation Of Calcium Ion Transport Synaptic Transmission Vascular Endothelial Growth Factor Receptor Signaling Pathway Cellular Metal Ion Homeostasis Cellular Cation Homeostasis Cellular Ion Homeostasis Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Metal Ion Homeostasis Energy Reserve Metabolic Process Cellular Chemical Homeostasis Signaling Positive Regulation Of Cytosolic Calcium Ion Concentration Metal Ion Transport Epidermal Growth Factor Receptor Signaling Pathway Fibroblast Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Cell Communication Ion Homeostasis Chemical Homeostasis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cell-cell Signaling Response To Stimulus Cation Transmembrane Transport Cellular Response To Fibroblast Growth Factor Stimulus Regulation Of Ion Transport Response To Fibroblast Growth Factor Regulation Of Calcium Ion Transport Into Cytosol
Tagcloud ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Difference) ?		anx7 apoj cadherin2 consequent cytokeratin discriminate fasted genomically glut increment ip3 ip3receptor iptr3 islets langerhans libidum littermate message neuro nutritionally oncostatin overnight pax6 pdx phosphoglucoisomerase preproglucagon principally profoundly virtually	channels clamp coexisting crac currents electrophysiological entry existence hek293 imax imin indicative influx ins modes modulators native norm operated patch scarce sensors stim1 stim2 store switch talk trpc1
Tagcloud (Intersection) ?