MEF2B and CABIN1

Number of citations of the paper that reports this interaction (PMID 12700764)
24

Data Source:
HPRD (in vitro)

		MEF2B	CABIN1
Gene Name		myocyte enhancer factor 2B	calcineurin binding protein 1
Image
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Cell Junction	Nucleoplasm Cytoplasm Aggresome
	Molecular Function	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription Sequence-specific DNA Binding Transcription Factor Activity Histone Deacetylase Binding Protein Dimerization Activity	Protein Phosphatase Inhibitor Activity
	Biological Process	Transcription, DNA-templated Muscle Organ Development Positive Regulation Of Transcription From RNA Polymerase II Promoter	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Chromatin Modification Negative Regulation Of Catalytic Activity
Pathways		CDO in myogenesis Myogenesis	DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence
Drugs
Diseases
GWAS			Amyotrophic lateral sclerosis ( 23624525)
Protein-Protein Interactions		2 interactors: CABIN1 HDAC4	12 interactors: AMPH CALM1 CAMK4 DNM1 H3F3A MEF2B MEF2BNB-MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ
Entrez ID		100271849	23523
HPRD ID		19467	10369
Ensembl ID		ENSG00000213999	ENSG00000099991
Uniprot IDs		Q02080	G5E9F3 Q6PHY0 Q9Y6J0
PDB IDs		1N6J 1TQE	1N6J
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Glycolytic Process Peptidyl-lysine Deacetylation Response To Denervation Involved In Regulation Of Muscle Adaptation Chromatin Modification Response To Inactivity Chromatin Organization Negative Regulation Of Myotube Differentiation Positive Regulation Of Protein Sumoylation Regulation Of Skeletal Muscle Fiber Development Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Striated Muscle Cell Differentiation Regulation Of Protein Sumoylation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Chromosome Organization Histone H4 Deacetylation Regulation Of Glycolytic Process Cardiac Muscle Hypertrophy Osteoblast Development Muscle Hypertrophy Histone H3 Deacetylation DNA Replication-independent Nucleosome Assembly Histone H3-K9 Modification Negative Regulation Of Muscle Cell Differentiation Negative Regulation Of Osteoblast Differentiation Regulation Of Myotube Differentiation Histone Deacetylation Regulation Of Skeletal Muscle Tissue Development Protein Deacetylation Regulation Of Generation Of Precursor Metabolites And Energy Regulation Of Cardiac Muscle Contraction Negative Regulation Of Ossification Response To Interleukin-1 Regulation Of Striated Muscle Contraction Calcium-mediated Signaling Regulation Of Striated Muscle Cell Differentiation B Cell Differentiation Negative Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Nucleosome Assembly Regulation Of Osteoblast Differentiation Chromatin Assembly Regulation Of Striated Muscle Tissue Development Osteoblast Differentiation Second-messenger-mediated Signaling Nucleosome Organization Regulation Of Protein Binding Regulation Of Carbohydrate Metabolic Process Regulation Of Muscle Cell Differentiation Chromatin Assembly Or Disassembly Regulation Of Muscle Contraction B Cell Activation	Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Calcineurin-NFAT Signaling Cascade Regulation Of Cellular Localization Positive Regulation Of NFAT Protein Import Into Nucleus Calcium-mediated Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleocytoplasmic Transport Inositol Phosphate-mediated Signaling Regulation Of Protein Localization Second-messenger-mediated Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Amphetamine Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Nucleocytoplasmic Transport Synaptic Transmission Substantia Nigra Development Positive Regulation Of Transcription Factor Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Establishment Of Localization In Cell Organ Development System Development Response To Amine Regulation Of Intracellular Protein Transport Regulation Of Transcription, DNA-templated Cell Activation Learning Or Memory Activation Of Phospholipase C Activity Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Muscle Organ Development Neural Nucleus Development Regulation Of RNA Metabolic Process Cellular Response To Drug Positive Regulation Of Phospholipase C Activity Cognition Positive Regulation Of Mitochondrion Organization Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Transition Between Fast And Slow Fiber Positive Regulation Of Protein Transport Multicellular Organismal Development Cellular Localization
Tagcloud ?		aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	actively caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Difference) ?		aberrations additional advances approaches biological closely contribute crebbp ep300 epha7 expected ezh2 fl follicular genetic hallmark hand individuals lymphoma microenvironment mll2 pathogenesis recognized recurrent technology tnfrsf14 translocation understanding unique	actively caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn
Tagcloud (Intersection) ?