CABIN1 and CAMK4

Number of citations of the paper that reports this interaction (PMID 15902271)
7

Data Source:
BioGRID (enzymatic study)

		CABIN1	CAMK4
Gene Name		calcineurin binding protein 1	calcium/calmodulin-dependent protein kinase IV
Image
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Aggresome	Nucleoplasm Nucleolus Cytosol Extracellular Vesicular Exosome
	Molecular Function	Protein Phosphatase Inhibitor Activity	Calmodulin-dependent Protein Kinase Activity Calmodulin Binding ATP Binding
	Biological Process	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Chromatin Modification Negative Regulation Of Catalytic Activity	Myeloid Dendritic Cell Cytokine Production Protein Phosphorylation Nucleocytoplasmic Transport Inflammatory Response Organelle Organization Mitochondrion Organization Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Activation Of Phospholipase C Activity Synaptic Transmission Neuron-neuron Synaptic Transmission Long-term Memory Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of T Cell Differentiation In Thymus Myeloid Dendritic Cell Differentiation Innate Immune Response Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Export From Nucleus Neurotrophin TRK Receptor Signaling Pathway
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence	Signaling by GPCR Ca-dependent events CaM pathway Organelle biogenesis and maintenance Signaling by FGFR in disease Phospholipase C-mediated cascade Signaling by EGFRvIII in Cancer PLCG1 events in ERBB2 signaling DAG and IP3 signaling CaM pathway DAP12 signaling Downstream signaling of activated FGFR Activation of NMDA receptor upon glutamate binding and postsynaptic events Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell Post NMDA receptor activation events Innate Immune System Signaling by PDGF Calmodulin induced events Signalling by NGF CaMK IV-mediated phosphorylation of CREB DAP12 interactions PLC beta mediated events Opioid Signalling Signaling by Ligand-Responsive EGFR Variants in Cancer NGF signalling via TRKA from the plasma membrane G-protein mediated events Signaling by Overexpressed Wild-Type EGFR in Cancer Signaling by FGFR EGFR interacts with phospholipase C-gamma Mitochondrial biogenesis Signaling by ERBB2 CaMK IV-mediated phosphorylation of CREB Signaling by EGFR Activation of CaMK IV CREB phosphorylation through the activation of CaMKK Downstream signal transduction Calmodulin induced events PLC-gamma1 signalling Signaling by EGFR in Cancer Transcriptional activation of mitochondrial biogenesis Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 23624525)	Alzheimer's disease (cognitive decline) ( 23535033) Blood pressure ( 17903302)
Protein-Protein Interactions		12 interactors: AMPH CALM1 CAMK4 DNM1 H3F3A MEF2B MEF2BNB-MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	10 interactors: CABIN1 CAMKK1 CAMKK2 CREBBP GAPDH HDAC4 NEDD4 NOS1 NOTCH1 RELA
Entrez ID		23523	814
HPRD ID		10369	07169
Ensembl ID		ENSG00000099991
Uniprot IDs		G5E9F3 Q6PHY0 Q9Y6J0	Q16566
PDB IDs		1N6J	2W4O
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Calcineurin-NFAT Signaling Cascade Regulation Of Cellular Localization Positive Regulation Of NFAT Protein Import Into Nucleus Calcium-mediated Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleocytoplasmic Transport Inositol Phosphate-mediated Signaling Regulation Of Protein Localization Second-messenger-mediated Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Amphetamine Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Nucleocytoplasmic Transport Synaptic Transmission Substantia Nigra Development Positive Regulation Of Transcription Factor Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Establishment Of Localization In Cell Organ Development System Development Response To Amine Regulation Of Intracellular Protein Transport Regulation Of Transcription, DNA-templated Cell Activation Learning Or Memory Activation Of Phospholipase C Activity Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Muscle Organ Development Neural Nucleus Development Regulation Of RNA Metabolic Process Cellular Response To Drug Positive Regulation Of Phospholipase C Activity Cognition Positive Regulation Of Mitochondrion Organization Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Transition Between Fast And Slow Fiber Positive Regulation Of Protein Transport Multicellular Organismal Development Cellular Localization	Negative Regulation Of Gene Expression Negative Regulation Of Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Peptidyl-cysteine S-nitrosylation Regulation Of DNA-templated Transcription In Response To Stress Negative Regulation Of Cellular Metabolic Process Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Myotube Differentiation Positive Regulation Of Gene Expression Positive Regulation Of Cellular Biosynthetic Process Protein Metabolic Process Response To Muramyl Dipeptide Signaling Peptidyl-amino Acid Modification Cell Communication Second-messenger-mediated Signaling Negative Regulation Of Striated Muscle Cell Differentiation Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Transcription From RNA Polymerase II Promoter Cellular Protein Metabolic Process Response To Abiotic Stimulus Negative Regulation Of Transcription, DNA-templated Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Negative Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cellular Protein Modification Process Cellular Response To Stimulus Immune System Process Regulation Of Protein Metabolic Process Immune Response Regulation Of Gene Expression Positive Regulation Of Metabolic Process Positive Regulation Of Glial Cell Differentiation Response To Stress Defense Response Endocardial Cushion Development Response To Cytokine Negative Regulation Of Muscle Cell Differentiation Signal Transduction Negative Regulation Of Osteoblast Differentiation Response To Organic Substance Positive Regulation Of Gliogenesis Response To Hypoxia Regulation Of Metabolic Process Positive Regulation Of Cellular Metabolic Process Regulation Of Cell Differentiation Regulation Of Myotube Differentiation Regulation Of Cell Development
Tagcloud ?		actively caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
Tagcloud (Difference) ?		actively caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	7r believed cd27 cd28 cd8 cxcr1 cytolytic cytotoxic dapk1 differentiated effector exerted explained highlighted homeostasis il inf produce producers producing productivity proliferative promoted similarly spry2 subset subsets substantial terminally
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