CABIN1 and PPP3CB

Number of citations of the paper that reports this interaction (PMID 9655484)
39

Data Source:
HPRD (in vivo, two hybrid)

		CABIN1	PPP3CB
Gene Name		calcineurin binding protein 1	protein phosphatase 3, catalytic subunit, beta isozyme
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleoplasm Cytoplasm Aggresome	Nucleoplasm Cytosol Plasma Membrane Calcineurin Complex Z Disc T-tubule
	Molecular Function	Protein Phosphatase Inhibitor Activity	Protein Serine/threonine Phosphatase Activity Calcium Ion Binding Protein Binding Calmodulin Binding Drug Binding Enzyme Binding Protein Phosphatase 2B Binding Calmodulin-dependent Protein Phosphatase Activity Protein Dimerization Activity
	Biological Process	DNA Replication-independent Nucleosome Assembly Cell Surface Receptor Signaling Pathway Chromatin Modification Negative Regulation Of Catalytic Activity	Negative Regulation Of T Cell Mediated Cytotoxicity Protein Phosphorylation Protein Dephosphorylation Signal Transduction Heart Development Learning Memory Dephosphorylation Calcium Ion-dependent Exocytosis T Cell Differentiation Locomotion Involved In Locomotory Behavior Calcineurin-NFAT Signaling Cascade Response To Cytokine Social Behavior Cellular Response To Drug Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Fc-epsilon Receptor Signaling Pathway T Cell Proliferation T Cell Activation T Cell Homeostasis Innate Immune Response Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Regulation Of Synaptic Plasticity Axon Extension Regulation Of Insulin Secretion Positive Regulation Of NFAT Protein Import Into Nucleus
Pathways		DNA Damage/Telomere Stress Induced Senescence Formation of Senescence-Associated Heterochromatin Foci (SAHF) Cellular Senescence	Signaling by GPCR Ca2+ pathway Opioid Signalling DARPP-32 events Fc epsilon receptor (FCERI) signaling FCERI mediated Ca+2 mobilization Signaling by Wnt Innate Immune System beta-catenin independent WNT signaling
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis ( 23624525)
Protein-Protein Interactions		12 interactors: AMPH CALM1 CAMK4 DNM1 H3F3A MEF2B MEF2BNB-MEF2B MEF2D PPP3CA PPP3CB PPP3CC YWHAQ	12 interactors: CABIN1 IRAK1 IRF2 JUN MARCH7 MYOZ2 MYOZ3 NFATC2 SLC8A1 SLC8A2 SLC8A3 SOCS3
Entrez ID		23523	5532
HPRD ID		10369	00235
Ensembl ID		ENSG00000099991	ENSG00000107758
Uniprot IDs		G5E9F3 Q6PHY0 Q9Y6J0	P16298
PDB IDs		1N6J
Enriched GO Terms of Interacting Partners?		Regulation Of Intracellular Transport Positive Regulation Of Intracellular Transport Positive Regulation Of Transport Calcineurin-NFAT Signaling Cascade Regulation Of Cellular Localization Positive Regulation Of NFAT Protein Import Into Nucleus Calcium-mediated Signaling Regulation Of Establishment Of Protein Localization Positive Regulation Of Nucleocytoplasmic Transport Inositol Phosphate-mediated Signaling Regulation Of Protein Localization Second-messenger-mediated Signaling Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Intracellular Protein Transport Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Response To Amphetamine Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway Regulation Of Nucleocytoplasmic Transport Synaptic Transmission Substantia Nigra Development Positive Regulation Of Transcription Factor Import Into Nucleus Fc-epsilon Receptor Signaling Pathway Establishment Of Localization In Cell Organ Development System Development Response To Amine Regulation Of Intracellular Protein Transport Regulation Of Transcription, DNA-templated Cell Activation Learning Or Memory Activation Of Phospholipase C Activity Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Transcription, DNA-templated Fc Receptor Signaling Pathway Regulation Of RNA Biosynthetic Process Muscle Organ Development Neural Nucleus Development Regulation Of RNA Metabolic Process Cellular Response To Drug Positive Regulation Of Phospholipase C Activity Cognition Positive Regulation Of Mitochondrion Organization Innate Immune Response Positive Regulation Of Macromolecule Biosynthetic Process Transition Between Fast And Slow Fiber Positive Regulation Of Protein Transport Multicellular Organismal Development Cellular Localization	Calcium Ion Export Response To Wounding Innate Immune Response Response To Organonitrogen Compound Response To Stress Blood Coagulation Hemostasis Response To Purine-containing Compound Cellular Response To Organic Substance Cell Communication Sodium Ion Transmembrane Transport Regulation Of Body Fluid Levels Calcium Ion Import Calcium Ion Transmembrane Transport Wound Healing Immune Response Regulation Of Innate Immune Response Immune System Process Sodium Ion Transport Defense Response Calcium Ion Transport Into Cytosol Cytosolic Calcium Ion Transport Response To Cytokine Toll-like Receptor 5 Signaling Pathway Toll-like Receptor 10 Signaling Pathway Toll-like Receptor TLR6:TLR2 Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Toll-like Receptor TLR1:TLR2 Signaling Pathway Calcium Ion Transport Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 9 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Response To Organic Substance MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Regulation Of Immune Response Cellular Response To Potassium Ion Starvation MyD88-dependent Toll-like Receptor Signaling Pathway Toll-like Receptor 4 Signaling Pathway Regulation Of Cytokine-mediated Signaling Pathway Calcium Ion Import Into Cell Calcium Ion Export From Cell Leading Edge Cell Differentiation Sodium Ion Import Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress Cytokine-mediated Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Immune Response-regulating Signaling Pathway Type I Interferon Signaling Pathway Cellular Response To Type I Interferon
Tagcloud ?		actively caf calcineurin concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	actinin aligned bigenic calcineurin cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Difference) ?		actively caf concomitantly constituting coordinated copyright crosses deposit extractable fertility heterochromatic hir hira impacts imply inheritance nucleosome occupancy orthologs pericentromeric preserve rescues reserved rights transcribed transposons ubinuclein ubn	actinin aligned bigenic cardiomyopathy constituted disk disks flag gross hcm hemizygous hypertrophic hypertrophy i246m jnk54 lentiviral likewise luc mal myoz2 myozenin nfatc pp2b quantifying rcan1 s48p transgene unsettled
Tagcloud (Intersection) ?		calcineurin