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Search Results for: TLE5

165 interactions involving TLE5 - TLE family member 5, transcriptional modulator found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
ABI2 abl interactor 2
  • Regulation of actin dynamics for phagocytic cup formation
  • Regulation of actin dynamics for phagocytic cup formation
  • VEGFA-VEGFR2 Pathway
  • RHO GTPases Activate WASPs and WAVEs
  • RHO GTPases Activate WASPs and WAVEs
  • FCGR3A-mediated phagocytosis
  • FCGR3A-mediated phagocytosis
AEN apoptosis enhancing nuclease
AMH anti-Mullerian hormone
  • Signaling by BMP
  • 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
AR androgen receptor
  • HSP90 chaperone cycle for steroid hormone receptors (SHR)
  • Nuclear Receptor transcription pathway
  • SUMOylation of intracellular receptors
  • Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
  • Ub-specific processing proteases
  • RUNX2 regulates osteoblast differentiation
  • RUNX2 regulates osteoblast differentiation
  • Diethylstilbestrol
  • Levonorgestrel
  • Progesterone
  • Spironolactone
  • Flutamide
  • Oxandrolone
  • Fluphenazine
  • Testosterone
  • Mitotane
  • Estrone
  • Nilutamide
  • Tamoxifen
  • Fludrocortisone
  • Drostanolone
  • Norgestimate
  • Nandrolone phenpropionate
  • Ketoconazole
  • Acetophenazine
  • Bicalutamide
  • Fluoxymesterone
  • Drospirenone
  • Danazol
  • Testosterone Propionate
  • Oxybenzone
  • Delta1-dihydrotestosterone
  • Boldenone
  • Calusterone
  • Propericiazine
  • Prasterone
  • Flufenamic Acid
  • Dihydrotestosterone
  • (R)-Bicalutamide
  • Methyltrienolone
  • (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
  • Cyproterone acetate
  • LGD2941
  • Oxymetholone
  • Methyltestosterone
  • Norelgestromin
  • 17-HYDROXY-18A-HOMO-19-NOR-17ALPHA-PREGNA-4,9,11-TRIEN-3-ONE
  • (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
  • 2-CHLORO-4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-3-METHYLBENZONITRILE
  • (2S)-3-(4-chloro-3-fluorophenoxy)-N-[4-cyano-3-(trifluoromethyl)phenyl]-2-hydroxy-2-methylpropanamide
  • 4-{[(1R,2S)-1,2-dihydroxy-2-methyl-3-(4-nitrophenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
  • (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
  • (2S)-3-[4-(acetylamino)phenoxy]-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
  • (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
  • (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
  • S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
  • 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
  • 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
  • 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
  • 6-[BIS(2,2,2-TRIFLUOROETHYL)AMINO]-4-(TRIFLUOROMETHYL)QUINOLIN-2(1H)-ONE
  • 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
  • Triclosan
  • Nandrolone decanoate
  • Ulipristal
  • Enzalutamide
  • Eugenol
  • Dienogest
  • Norgestrel
  • Homosalate
  • Enzacamene
  • Esculin
  • 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
  • 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
  • Prostate cancer
  • Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
ARHGAP32 Rho GTPase activating protein 32
  • Rho GTPase cycle
ATN1 atrophin 1
  • Regulation of PTEN gene transcription
  • Dentatorubropallidoluysian atrophy (DRPLA)
ATP6V0D1 ATPase H+ transporting V0 subunit d1
  • ROS and RNS production in phagocytes
  • XBP1(S) activates chaperone genes
  • Insulin receptor recycling
  • Transferrin endocytosis and recycling
  • Amino acids regulate mTORC1
  • Ion channel transport
BAHD1 bromo adjacent homology domain containing 1
BCL6 BCL6 transcription repressor
  • Interleukin-4 and Interleukin-13 signaling
  • TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
  • FOXO-mediated transcription of cell death genes
  • Hairy-cell leukemia
BHLHE40 basic helix-loop-helix family member e40
  • BMAL1:CLOCK,NPAS2 activates circadian gene expression
BIRC7 baculoviral IAP repeat containing 7
BYSL bystin like
  • Major pathway of rRNA processing in the nucleolus and cytosol
C1orf109 chromosome 1 open reading frame 109
C1orf216 chromosome 1 open reading frame 216
C1orf94 chromosome 1 open reading frame 94
CABP4 calcium binding protein 4
  • Congenital stationary night blindness (CSNB), including: CSNB type 1 (CSNB1); CSNB type 2 (CSNB2); CSNB autosomal dominant (CSNBAD); Oguchi disease/ CSNB Oguchi type (CSNBO)
CALCOCO2 calcium binding and coiled-coil domain 2
CAPN1 calpain 1
  • Degradation of the extracellular matrix
  • Degradation of the extracellular matrix
  • Neutrophil degranulation
  • Formation of the cornified envelope
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
  • N-[N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-Butyl]-Guanidine
  • CBZ-LEU-LEU-TYR-CH2F
  • (2S)-4-METHYL-2-(3-PHENYLTHIOUREIDO)-N-((3S)-TETRAHYDRO-2-HYDROXY-3-FURANYL)PENTANAMIDE
CARD9 caspase recruitment domain family member 9
  • NOD1/2 Signaling Pathway
  • CLEC7A (Dectin-1) signaling
  • Chronic Mucocutaneous Candidiasis (CMC); Familial candidiasis (CANDF)
CCDC57 coiled-coil domain containing 57
CCL7 C-C motif chemokine ligand 7
  • Chemokine receptors bind chemokines
CCNJL cyclin J like
CCNK cyclin K
  • Formation of RNA Pol II elongation complex
  • Formation of HIV elongation complex in the absence of HIV Tat
  • HIV elongation arrest and recovery
  • Pausing and recovery of HIV elongation
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • RNA Polymerase II Pre-transcription Events
  • TP53 Regulates Transcription of DNA Repair Genes
  • RNA polymerase II transcribes snRNA genes
  • RNA polymerase II transcribes snRNA genes
  • RNA Polymerase II Transcription Elongation
CFAP206 cilia and flagella associated protein 206
CIB3 calcium and integrin binding family member 3
CPSF7 cleavage and polyadenylation specific factor 7
  • mRNA Splicing - Major Pathway
  • mRNA 3'-end processing
  • RNA Polymerase II Transcription Termination
  • Processing of Intronless Pre-mRNAs
CRACR2A calcium release activated channel regulator 2A
  • Neutrophil degranulation
CRX cone-rod homeobox
  • Leber congenital amaurosis (LCR)
  • Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
DCUN1D1 defective in cullin neddylation 1 domain containing 1
  • Neddylation
DDX6 DEAD-box helicase 6
  • mRNA decay by 5' to 3' exoribonuclease
  • D-tartaric acid
DGCR6 DiGeorge syndrome critical region gene 6
DIP2A disco interacting protein 2 homolog A
DNMT3L DNA methyltransferase 3 like
  • DNA methylation
DVL2 dishevelled segment polarity protein 2
  • TCF dependent signaling in response to WNT
  • WNT mediated activation of DVL
  • Signaling by Hippo
  • PCP/CE pathway
  • PCP/CE pathway
  • Asymmetric localization of PCP proteins
  • Degradation of DVL
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • Disassembly of the destruction complex and recruitment of AXIN to the membrane
  • WNT5A-dependent internalization of FZD4
  • Negative regulation of TCF-dependent signaling by DVL-interacting proteins
  • RHO GTPases Activate Formins
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • WNT5:FZD7-mediated leishmania damping
  • WNT5:FZD7-mediated leishmania damping
EAF1 ELL associated factor 1
  • Formation of RNA Pol II elongation complex
  • RNA Polymerase II Pre-transcription Events
  • RNA Polymerase II Transcription Elongation
EAF2 ELL associated factor 2
  • Formation of RNA Pol II elongation complex
  • RNA Polymerase II Pre-transcription Events
  • RNA Polymerase II Transcription Elongation
EIF4E2 eukaryotic translation initiation factor 4E family member 2
  • ISG15 antiviral mechanism
FAM124A family with sequence similarity 124 member A
FAM124B family with sequence similarity 124 member B
FANCG FA complementation group G
  • Fanconi Anemia Pathway
  • Fanconi anemia
FBF1 Fas binding factor 1
  • Anchoring of the basal body to the plasma membrane
FBLN1 fibulin 1
  • Molecules associated with elastic fibres
  • Molecules associated with elastic fibres
  • Synpolydactyly, 3/3'4, associated with metacarpal and metatarsal synostoses
FHL3 four and a half LIM domains 3
FOXP2 forkhead box P2
  • Speech-language disorder 1 (SPCH1)
FRS3 fibroblast growth factor receptor substrate 3
  • FRS-mediated FGFR1 signaling
  • FRS-mediated FGFR2 signaling
  • FRS-mediated FGFR3 signaling
  • FRS-mediated FGFR4 signaling
  • RAF/MAP kinase cascade
  • Activated NTRK2 signals through FRS2 and FRS3
FSD2 fibronectin type III and SPRY domain containing 2
GABARAP GABA type A receptor-associated protein
  • Macroautophagy
  • TBC/RABGAPs
GFAP glial fibrillary acidic protein
  • Nuclear signaling by ERBB4
  • Chaperone Mediated Autophagy
  • Alexander disease
GFI1B growth factor independent 1B transcriptional repressor
GLRX3 glutaredoxin 3
  • Iron uptake and transport
GOLGA2 golgin A2
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • Golgi Cisternae Pericentriolar Stack Reorganization
  • COPII-mediated vesicle transport
  • COPI-mediated anterograde transport
  • Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
GORASP2 golgi reassembly stacking protein 2
  • Golgi Cisternae Pericentriolar Stack Reorganization
GRAP2 GRB2 related adaptor protein 2
  • Signaling by SCF-KIT
  • Generation of second messenger molecules
  • DAP12 signaling
  • FCERI mediated MAPK activation
  • FCERI mediated Ca+2 mobilization
  • FCERI mediated Ca+2 mobilization
  • CD28 co-stimulation
GRB2 growth factor receptor bound protein 2
  • Interleukin-15 signaling
  • Interleukin-15 signaling
  • Pegademase bovine
  • 4-[(10s,14s,18s)-18-(2-Amino-2-Oxoethyl)-14-(1-Naphthylmethyl)-8,17,20-Trioxo-7,16,19-Triazaspiro[5.14]Icos-11-En-10-Yl]Benzylphosphonic Acid
GTF2E1 general transcription factor IIE subunit 1
  • HIV Transcription Initiation
  • RNA Polymerase II HIV Promoter Escape
  • Transcription of the HIV genome
  • RNA Polymerase II Pre-transcription Events
  • RNA polymerase II transcribes snRNA genes
  • RNA polymerase II transcribes snRNA genes
  • RNA Polymerase II Promoter Escape
  • RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
  • RNA Polymerase II Transcription Initiation
  • RNA Polymerase II Transcription Initiation And Promoter Clearance
HCN2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2
  • HCN channels
  • Cyclic Guanosine Monophosphate
  • Cyclic Adenosine Monophosphate
HGS hepatocyte growth factor-regulated tyrosine kinase substrate
  • EGFR downregulation
  • Lysosome Vesicle Biogenesis
  • Ub-specific processing proteases
  • Negative regulation of MET activity
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • Inhibition of membrane repair
  • Prevention of phagosomal-lysosomal fusion
  • Citric Acid
HMGB1 high mobility group box 1
  • Apoptosis induced DNA fragmentation
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • Regulation of TLR by endogenous ligand
  • Neutrophil degranulation
  • Advanced glycosylation endproduct receptor signaling
  • Advanced glycosylation endproduct receptor signaling
  • TRAF6 mediated NF-kB activation
  • Ethyl pyruvate
HNF1A HNF1 homeobox A
  • Regulation of gene expression in beta cells
  • D-norleucine
  • Maturity onset diabetes of the young (MODY)
HNRNPF heterogeneous nuclear ribonucleoprotein F
  • FGFR2 alternative splicing
  • mRNA Splicing - Major Pathway
  • Processing of Capped Intron-Containing Pre-mRNA
  • Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
  • Phenethyl Isothiocyanate
HNRNPH2 heterogeneous nuclear ribonucleoprotein H2
  • mRNA Splicing - Major Pathway
  • Processing of Capped Intron-Containing Pre-mRNA
HNRNPLL heterogeneous nuclear ribonucleoprotein L like
HOMEZ homeobox and leucine zipper encoding
IKZF3 IKAROS family zinc finger 3
KANK2 KN motif and ankyrin repeat domains 2
KIFC3 kinesin family member C3
KRT13 keratin 13
  • Keratinization
  • Formation of the cornified envelope
  • White sponge nevus
KRT15 keratin 15
  • Keratinization
  • Formation of the cornified envelope
KRT31 keratin 31
  • Keratinization
  • Formation of the cornified envelope
KRT40 keratin 40
  • Keratinization
  • Formation of the cornified envelope
KRTAP10-3 keratin associated protein 10-3
  • Keratinization
KRTAP10-7 keratin associated protein 10-7
  • Keratinization
KRTAP10-8 keratin associated protein 10-8
  • Keratinization
KRTAP10-9 keratin associated protein 10-9
  • Keratinization
L3MBTL2 L3MBTL histone methyl-lysine binding protein 2
  • SUMOylation of chromatin organization proteins
  • Transcriptional Regulation by E2F6
LDOC1 LDOC1 regulator of NFKB signaling
LINC00526 long intergenic non-protein coding RNA 526
LMO1 LIM domain only 1
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
LMO2 LIM domain only 2
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia)
LMO4 LIM domain only 4
LSM2 LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA decay by 5' to 3' exoribonuclease
  • mRNA Splicing - Major Pathway
  • mRNA Splicing - Minor Pathway
MAGOHB mago homolog B, exon junction complex subunit
  • Transport of Mature mRNA derived from an Intron-Containing Transcript
  • mRNA Splicing - Major Pathway
  • mRNA 3'-end processing
  • RNA Polymerase II Transcription Termination
  • Regulation of expression of SLITs and ROBOs
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
MAPK14 mitogen-activated protein kinase 14
  • NOD1/2 Signaling Pathway
  • p38MAPK events
  • p38MAPK events
  • ERK/MAPK targets
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation
  • Oxidative Stress Induced Senescence
  • DSCAM interactions
  • ADP signalling through P2Y purinoceptor 1
  • Platelet sensitization by LDL
  • VEGFA-VEGFR2 Pathway
  • activated TAK1 mediates p38 MAPK activation
  • Activation of the AP-1 family of transcription factors
  • KSRP (KHSRP) binds and destabilizes mRNA
  • Myogenesis
  • Myogenesis
  • RHO GTPases Activate NADPH Oxidases
  • Neutrophil degranulation
  • Regulation of TP53 Activity through Phosphorylation
  • CD163 mediating an anti-inflammatory response
  • Dasatinib
  • 4-[5-[2-(1-Phenyl-Ethylamino)-Pyrimidin-4-Yl]-1-Methyl-4-(3-Trifluoromethylphenyl)-1h-Imidazol-2-Yl]-Piperidine
  • N-[(3z)-5-Tert-Butyl-2-Phenyl-1,2-Dihydro-3h-Pyrazol-3-Ylidene]-N'-(4-Chlorophenyl)Urea
  • 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperidin-4-Yl-3,4-Dihydroquinolin-2(1h)-One
  • Inhibitor of P38 Kinase
  • 6((S)-3-Benzylpiperazin-1-Yl)-3-(Naphthalen-2-Yl)-4-(Pyridin-4-Yl)Pyrazine
  • 3-(4-Fluorophenyl)-1-Hydroxy-2-(Pyridin-4-Yl)-1h-Pyrrolo[3,2-B]Pyridine
  • 1-(5-Tert-Butyl-2-Methyl-2h-Pyrazol-3-Yl)-3-(4-Chloro-Phenyl)-Urea
  • 3-(Benzyloxy)Pyridin-2-Amine
  • 1-(2,6-Dichlorophenyl)-5-(2,4-Difluorophenyl)-7-Piperazin-1-Yl-3,4-Dihydroquinazolin-2(1h)-One
  • 4-[3-Methylsulfanylanilino]-6,7-Dimethoxyquinazoline
  • 1-(5-Tert-Butyl-2-P-Tolyl-2h-Pyrazol-3-Yl)-3-[4-(2-Morpholin-4-Yl-Ethoxy)-Naphthalen-1-Yl]-Urea
  • 2-Chlorophenol
  • 4-(Fluorophenyl)-1-Cyclopropylmethyl-5-(2-Amino-4-Pyrimidinyl)Imidazole
  • SB220025
  • 4-(2-HYDROXYBENZYLAMINO)-N-(3-(4-FLUOROPHENOXY)PHENYL)PIPERIDINE-1-SULFONAMIDE
  • Triazolopyridine
  • KC706
  • Talmapimod
  • VX-702
  • 1-[1-(3-aminophenyl)-3-tert-butyl-1H-pyrazol-5-yl]-3-naphthalen-1-ylurea
  • N-ethyl-4-{[5-(methoxycarbamoyl)-2-methylphenyl]amino}-5-methylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide
  • N-[2-methyl-5-(methylcarbamoyl)phenyl]-2-{[(1R)-1-methylpropyl]amino}-1,3-thiazole-5-carboxamide
  • Neflamapimod
  • N-cyclopropyl-4-methyl-3-[1-(2-methylphenyl)phthalazin-6-yl]benzamide
  • 4-PHENOXY-N-(PYRIDIN-2-YLMETHYL)BENZAMIDE
  • 4-[5-(3-IODO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-1H-IMIDAZOL-4-YL]-PYRIDINE
  • N-cyclopropyl-2',6-dimethyl-4'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-3-carboxamide
  • 4-[3-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL]PYRIDINE
  • 4-{4-[(5-hydroxy-2-methylphenyl)amino]quinolin-7-yl}-1,3-thiazole-2-carbaldehyde
  • N-(3-cyanophenyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)-4-biphenylcarboxamide
  • N-(cyclopropylmethyl)-2'-methyl-5'-(5-methyl-1,3,4-oxadiazol-2-yl)biphenyl-4-carboxamide
  • N~3~-cyclopropyl-N~4~'-(cyclopropylmethyl)-6-methylbiphenyl-3,4'-dicarboxamide
  • PH-797804
  • 2-fluoro-4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]pyridine
  • 2-{4-[5-(4-chlorophenyl)-4-pyrimidin-4-yl-1H-pyrazol-3-yl]piperidin-1-yl}-2-oxoethanol
  • N-(3-TERT-BUTYL-1H-PYRAZOL-5-YL)-N'-{4-CHLORO-3-[(PYRIDIN-3-YLOXY)METHYL]PHENYL}UREA
  • N-[4-CHLORO-3-(PYRIDIN-3-YLOXYMETHYL)-PHENYL]-3-FLUORO-
  • 3-FLUORO-5-MORPHOLIN-4-YL-N-[3-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-5-YL]BENZAMIDE
  • 3-fluoro-N-1H-indol-5-yl-5-morpholin-4-ylbenzamide
  • 3-(1-NAPHTHYLMETHOXY)PYRIDIN-2-AMINE
  • 3-(2-CHLOROPHENYL)-1-(2-{[(1S)-2-HYDROXY-1,2-DIMETHYLPROPYL]AMINO}PYRIMIDIN-4-YL)-1-(4-METHOXYPHENYL)UREA
  • 8-(2-CHLOROPHENYLAMINO)-2-(2,6-DIFLUOROPHENYLAMINO)-9-ETHYL-9H-PURINE-1,7-DIIUM
  • 2-(2,6-DIFLUOROPHENOXY)-N-(2-FLUOROPHENYL)-9-ISOPROPYL-9H-PURIN-8-AMINE
  • N,4-dimethyl-3-[(1-phenyl-1H-pyrazolo[3,4-d]pyrimidin-4-yl)amino]benzamide
  • N-cyclopropyl-3-{[1-(2,4-difluorophenyl)-7-methyl-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-4-yl]amino}-4-methylbenzamide
  • N-cyclopropyl-4-methyl-3-{2-[(2-morpholin-4-ylethyl)amino]quinazolin-6-yl}benzamide
  • 6-[4-(2-fluorophenyl)-1,3-oxazol-5-yl]-N-(1-methylethyl)-1,3-benzothiazol-2-amine
  • 2-(ETHOXYMETHYL)-4-(4-FLUOROPHENYL)-3-[2-(2-HYDROXYPHENOXY)PYRIMIDIN-4-YL]ISOXAZOL-5(2H)-ONE
  • [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL][3-(PIPERIDIN-4-YLOXY)PHENYL]METHANONE
  • [5-AMINO-1-(4-FLUOROPHENYL)-1H-PYRAZOL-4-YL](3-{[(2R)-2,3-DIHYDROXYPROPYL]OXY}PHENYL)METHANONE
  • 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE
  • 4-(4-FLUOROPHENYL)-1-CYCLOROPROPYLMETHYL-5-(4-PYRIDYL)-IMIDAZOLE
  • 3-FLUORO-5-MORPHOLIN-4-YL-N-[1-(2-PYRIDIN-4-YLETHYL)-1H-INDOL-6-YL]BENZAMIDE
MBNL1 muscleblind like splicing regulator 1
MED31 mediator complex subunit 31
  • PPARA activates gene expression
  • Generic Transcription Pathway
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
MED4 mediator complex subunit 4
  • PPARA activates gene expression
  • Generic Transcription Pathway
  • Transcriptional regulation of white adipocyte differentiation
  • Transcriptional regulation of white adipocyte differentiation
MFAP1 microfibril associated protein 1
  • Molecules associated with elastic fibres
MIA2 MIA SH3 domain ER export factor 2
  • Cargo concentration in the ER
MKRN3 makorin ring finger protein 3
MLH1 mutL homolog 1
  • Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
  • Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
  • Defective Mismatch Repair Associated With MLH1
  • Defective Mismatch Repair Associated With PMS2
  • TP53 Regulates Transcription of DNA Repair Genes
  • Meiotic recombination
  • Colorectal cancer
  • Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
  • Endometrial Cancer
  • Ovarian cancer
MLX MAX dimerization protein MLX
  • ChREBP activates metabolic gene expression
  • ChREBP activates metabolic gene expression
MORF4L2 mortality factor 4 like 2
  • HATs acetylate histones
MSX1 msh homeobox 1
  • Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate
  • Tooth agenesis; Hypodontia
  • Tooth and nail syndrome; Witkop syndrome
MTUS2 microtubule associated scaffold protein 2
MVP major vault protein
  • Neutrophil degranulation
MYO15B myosin XVB
NAB2 NGFI-A binding protein 2
  • NGF-stimulated transcription
  • NGF-stimulated transcription
  • EGR2 and SOX10-mediated initiation of Schwann cell myelination
NCDN neurochondrin
NEK6 NIMA related kinase 6
  • Activation of NIMA Kinases NEK9, NEK6, NEK7
  • Nuclear Pore Complex (NPC) Disassembly
  • EML4 and NUDC in mitotic spindle formation
NOTCH2NLA notch 2 N-terminal like A
NTAQ1 N-terminal glutamine amidase 1
NUDT22 nudix hydrolase 22
OLIG3 oligodendrocyte transcription factor 3
OSGIN1 oxidative stress induced growth inhibitor 1
PARVG parvin gamma
PHKB phosphorylase kinase regulatory subunit beta
  • Glycogen breakdown (glycogenolysis)
  • Glycogen breakdown (glycogenolysis)
  • Glycogen storage diseases (GSD), including: von Gierke disease (GSD type Ia); Pompe disease (GSD type II); Cori disease, Forbe disease (GSD type III); Andersen disease (GSD type IV); McArdle disease (GSD type V); Hers disease (GSD type VI); Tarui disease (GSD type VII); Phosphorylase kinase deficiency (GSD type IX); Fanconi-Bickel syndrome (GSD type XI); Glycogen synthase deficiency (GSD type 0)
POU2F1 POU class 2 homeobox 1
  • Interleukin-4 and Interleukin-13 signaling
  • RNA polymerase II transcribes snRNA genes
  • RNA polymerase II transcribes snRNA genes
  • RNA Polymerase III Abortive And Retractive Initiation
  • RNA Polymerase III Transcription Initiation From Type 3 Promoter
  • RNA Polymerase III Transcription Initiation From Type 3 Promoter
  • Estrogen-dependent gene expression
PPP1R16A protein phosphatase 1 regulatory subunit 16A
PPP1R16B protein phosphatase 1 regulatory subunit 16B
PRDM1 PR/SET domain 1
  • Regulation of TP53 Expression
PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1
  • Macroautophagy
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Regulation of TP53 Activity through Phosphorylation
  • Activation of AMPK downstream of NMDARs
  • Adenosine monophosphate
  • ATP
  • Phenformin
  • Acetylsalicylic acid
PRKAA2 protein kinase AMP-activated catalytic subunit alpha 2
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Macroautophagy
  • AMPK inhibits chREBP transcriptional activation activity
  • AMPK inhibits chREBP transcriptional activation activity
  • Carnitine metabolism
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Regulation of TP53 Activity through Phosphorylation
  • Lipophagy
  • Activation of AMPK downstream of NMDARs
  • Acetylsalicylic acid
PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2
  • Translocation of SLC2A4 (GLUT4) to the plasma membrane
  • Macroautophagy
  • AMPK inhibits chREBP transcriptional activation activity
  • AMPK inhibits chREBP transcriptional activation activity
  • Carnitine metabolism
  • Activation of PPARGC1A (PGC-1alpha) by phosphorylation
  • Energy dependent regulation of mTOR by LKB1-AMPK
  • TP53 Regulates Metabolic Genes
  • Regulation of TP53 Activity through Phosphorylation
  • Lipophagy
  • Activation of AMPK downstream of NMDARs
  • Adenosine monophosphate
  • Acetylsalicylic acid
PRPF31 pre-mRNA processing factor 31
  • mRNA Splicing - Major Pathway
  • Retinitis pigmentosa (RP)
PRR3 proline rich 3
PSMF1 proteasome inhibitor subunit 1
  • Activation of NF-kappaB in B cells
  • Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
  • ER-Phagosome pathway
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Autodegradation of Cdh1 by Cdh1:APC/C
  • SCF-beta-TrCP mediated degradation of Emi1
  • APC/C:Cdc20 mediated degradation of Securin
  • APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
  • Cdc20:Phospho-APC/C mediated degradation of Cyclin A
  • Vpu mediated degradation of CD4
  • Vif-mediated degradation of APOBEC3G
  • SCF(Skp2)-mediated degradation of p27/p21
  • Degradation of beta-catenin by the destruction complex
  • Downstream TCR signaling
  • Regulation of activated PAK-2p34 by proteasome mediated degradation
  • Separation of Sister Chromatids
  • FCERI mediated NF-kB activation
  • Autodegradation of the E3 ubiquitin ligase COP1
  • Regulation of ornithine decarboxylase (ODC)
  • ABC-family proteins mediated transport
  • AUF1 (hnRNP D0) binds and destabilizes mRNA
  • Asymmetric localization of PCP proteins
  • Degradation of AXIN
  • Degradation of DVL
  • Hedgehog ligand biogenesis
  • Hh mutants that don't undergo autocatalytic processing are degraded by ERAD
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • Degradation of GLI1 by the proteasome
  • Degradation of GLI2 by the proteasome
  • GLI3 is processed to GLI3R by the proteasome
  • Hedgehog 'on' state
  • Regulation of RAS by GAPs
  • TNFR2 non-canonical NF-kB pathway
  • NIK - noncanonical NF-kB signaling
  • Defective CFTR causes cystic fibrosis
  • MAPK6/MAPK4 signaling
  • UCH proteinases
  • Ub-specific processing proteases
  • CDT1 association with the CDC6:ORC:origin complex
  • Orc1 removal from chromatin
  • CDK-mediated phosphorylation and removal of Cdc6
  • G2/M Checkpoints
  • Ubiquitin Mediated Degradation of Phosphorylated Cdc25A
  • Ubiquitin-dependent degradation of Cyclin D
  • The role of GTSE1 in G2/M progression after G2 checkpoint
  • FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX2 expression and activity
  • Regulation of RUNX3 expression and activity
  • Regulation of PTEN stability and activity
  • Neddylation
  • Regulation of expression of SLITs and ROBOs
  • Interleukin-1 signaling
  • Negative regulation of NOTCH4 signaling
  • Antigen processing: Ubiquitination & Proteasome degradation
PTRH2 peptidyl-tRNA hydrolase 2
  • Ub-specific processing proteases
QARS1 glutaminyl-tRNA synthetase 1
  • Selenoamino acid metabolism
  • Cytosolic tRNA aminoacylation
  • Mitochondrial tRNA aminoacylation
RBM10 RNA binding motif protein 10
  • TARP syndrome
RBPMS RNA binding protein, mRNA processing factor
REL REL proto-oncogene, NF-kB subunit
  • Activation of NF-kappaB in B cells
  • Hodgkin lymphoma
RELA RELA proto-oncogene, NF-kB subunit
  • Activation of NF-kappaB in B cells
  • RIP-mediated NFkB activation via ZBP1
  • Regulated proteolysis of p75NTR
  • Downstream TCR signaling
  • NF-kB is activated and signals survival
  • Senescence-Associated Secretory Phenotype (SASP)
  • FCERI mediated NF-kB activation
  • DEx/H-box helicases activate type I IFN and inflammatory cytokines production
  • PKMTs methylate histone lysines
  • Transcriptional regulation of white adipocyte differentiation
  • TAK1 activates NFkB by phosphorylation and activation of IKKs complex
  • Interleukin-1 processing
  • SUMOylation of immune response proteins
  • IkBA variant leads to EDA-ID
  • Dectin-1 mediated noncanonical NF-kB signaling
  • CLEC7A (Dectin-1) signaling
  • CD209 (DC-SIGN) signaling
  • CLEC7A/inflammasome pathway
  • The NLRP3 inflammasome
  • Transcriptional Regulation by VENTX
  • Interleukin-1 signaling
  • TRAF6 mediated NF-kB activation
  • Purinergic signaling in leishmaniasis infection
  • Dimethyl fumarate
RFX6 regulatory factor X6
  • Regulation of gene expression in beta cells
RHOXF2 Rhox homeobox family member 2
RIMBP3 RIMS binding protein 3
RNF31 ring finger protein 31
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
RPL18A ribosomal protein L18a
  • L13a-mediated translational silencing of Ceruloplasmin expression
  • Peptide chain elongation
  • SRP-dependent cotranslational protein targeting to membrane
  • SRP-dependent cotranslational protein targeting to membrane
  • Viral mRNA Translation
  • Selenocysteine synthesis
  • Major pathway of rRNA processing in the nucleolus and cytosol
  • Formation of a pool of free 40S subunits
  • GTP hydrolysis and joining of the 60S ribosomal subunit
  • Eukaryotic Translation Termination
  • Regulation of expression of SLITs and ROBOs
  • Response of EIF2AK4 (GCN2) to amino acid deficiency
  • Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
  • Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
RUNX1 RUNX family transcription factor 1
  • Pre-NOTCH Transcription and Translation
  • Organic cation transport
  • RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
  • RUNX1 regulates estrogen receptor mediated transcription
  • Regulation of RUNX1 Expression and Activity
  • Regulation of RUNX1 Expression and Activity
  • RUNX1 regulates expression of components of tight junctions
  • RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • RUNX1 regulates transcription of genes involved in differentiation of HSCs
  • RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
  • RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
  • RUNX1 regulates transcription of genes involved in BCR signaling
  • RUNX1 regulates transcription of genes involved in differentiation of myeloid cells
  • RUNX1 regulates transcription of genes involved in interleukin signaling
  • RUNX1 regulates transcription of genes involved in WNT signaling
  • RUNX2 regulates genes involved in differentiation of myeloid cells
  • RUNX3 regulates p14-ARF
  • Estrogen-dependent gene expression
  • Transcriptional regulation of granulopoiesis
  • Chronic myeloid leukemia (CML)
  • Thrombocytopenia (THC); Familial platelet disorder with associated myeloid malignancy (FPDMM)
  • Acute myeloid leukemia (AML)
  • Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia)
SCNM1 sodium channel modifier 1
SDCBP syndecan binding protein
  • Ephrin signaling
  • Neurofascin interactions
  • Neutrophil degranulation
SH3GL3 SH3 domain containing GRB2 like 3, endophilin A3
  • EGFR downregulation
  • Negative regulation of MET activity
  • Cargo recognition for clathrin-mediated endocytosis
  • Clathrin-mediated endocytosis
  • InlB-mediated entry of Listeria monocytogenes into host cell
  • NGF-stimulated transcription
SIX1 SIX homeobox 1
  • Contiguous gene deletion syndrome involving EYA1, including: Oto-facio-cervical syndrome (OFC); Branchiootic syndrome 1 (BOS1); Branchio-oto-renal syndrome (BOR)
SIX2 SIX homeobox 2
SIX3 SIX homeobox 3
  • Holoprosencephaly (HPE)
SIX6 SIX homeobox 6
  • Anophthalmia and microphthalmia (A/M)
SKIL SKI like proto-oncogene
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
SMAD3 SMAD family member 3
  • Signaling by NODAL
  • Signaling by NODAL
  • Signaling by Activin
  • Downregulation of TGF-beta receptor signaling
  • TGF-beta receptor signaling activates SMADs
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • Downregulation of SMAD2/3:SMAD4 transcriptional activity
  • SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription
  • SMAD2/3 Phosphorylation Motif Mutants in Cancer
  • SMAD4 MH2 Domain Mutants in Cancer
  • SMAD2/3 MH2 Domain Mutants in Cancer
  • TGFBR1 KD Mutants in Cancer
  • Ub-specific processing proteases
  • RUNX3 regulates CDKN1A transcription
  • RUNX3 regulates BCL2L11 (BIM) transcription
  • Interleukin-37 signaling
  • NOTCH4 Intracellular Domain Regulates Transcription
  • FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
  • FOXO-mediated transcription of cell cycle genes
  • FOXO-mediated transcription of cell cycle genes
SMARCB1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1
  • RMTs methylate histone arginines
  • RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
SNCAIP synuclein alpha interacting protein
  • Amyloid fiber formation
SNRPC small nuclear ribonucleoprotein polypeptide C
  • mRNA Splicing - Major Pathway
SOX5 SRY-box transcription factor 5
SRPK2 SRSF protein kinase 2
  • Adenine
  • Purvalanol
  • Phosphoaminophosphonic Acid-Adenylate Ester
STK16 serine/threonine kinase 16
STX11 syntaxin 11
  • Familial hemophagocytic lymphohistiocytosis (FHPL), including the following three diseases: Perforin deficiency; Munc deficiency; STX11 deficiency
SUPT5H SPT5 homolog, DSIF elongation factor subunit
  • Formation of RNA Pol II elongation complex
  • Formation of the Early Elongation Complex
  • Formation of HIV elongation complex in the absence of HIV Tat
  • Formation of the HIV-1 Early Elongation Complex
  • RNA Pol II CTD phosphorylation and interaction with CE during HIV infection
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Formation of HIV-1 elongation complex containing HIV-1 Tat
  • Pausing and recovery of Tat-mediated HIV elongation
  • Abortive elongation of HIV-1 transcript in the absence of Tat
  • Tat-mediated HIV elongation arrest and recovery
  • Tat-mediated elongation of the HIV-1 transcript
  • HIV elongation arrest and recovery
  • Pausing and recovery of HIV elongation
  • RNA Polymerase II Pre-transcription Events
  • TP53 Regulates Transcription of DNA Repair Genes
  • RNA polymerase II transcribes snRNA genes
  • mRNA Capping
  • RNA Polymerase II Transcription Elongation
  • RNA Pol II CTD phosphorylation and interaction with CE
TBX3 T-box transcription factor 3
  • Ulnar-mammary syndrome; Schinzel syndrome
TCF4 transcription factor 4
  • Myogenesis
  • Myogenesis
  • Pitt-Hopkins syndrome, including: Pitt-Hopkins syndrome; Pitt-Hopkins-like syndrome
TMCC2 transmembrane and coiled-coil domain family 2
TNS2 tensin 2
TRAF1 TNF receptor associated factor 1
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
TRAF2 TNF receptor associated factor 2
  • Caspase activation via Death Receptors in the presence of ligand
  • Regulation by c-FLIP
  • RIPK1-mediated regulated necrosis
  • CASP8 activity is inhibited
  • TNFR1-induced proapoptotic signaling
  • Regulation of TNFR1 signaling
  • TNFR1-induced NFkappaB signaling pathway
  • TNFR2 non-canonical NF-kB pathway
  • Regulation of necroptotic cell death
  • TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway
  • Ub-specific processing proteases
  • Dimerization of procaspase-8
  • TNF signaling
  • TRAF6 mediated IRF7 activation
  • TRAF6 mediated NF-kB activation
  • TRAF6 mediated NF-kB activation
TRIM26 tripartite motif containing 26
  • Interferon gamma signaling
TRIM27 tripartite motif containing 27
  • SUMOylation of ubiquitinylation proteins
  • Regulation of PTEN stability and activity
  • Suppression of apoptosis
TRIM41 tripartite motif containing 41
  • Antigen processing: Ubiquitination & Proteasome degradation
TSC22D4 TSC22 domain family member 4
TSGA10 testis specific 10
TSSK3 testis specific serine kinase 3
U2AF2 U2 small nuclear RNA auxiliary factor 2
  • Transport of Mature mRNA derived from an Intron-Containing Transcript
  • mRNA Splicing - Major Pathway
  • mRNA 3'-end processing
  • RNA Polymerase II Transcription Termination
UBE2H ubiquitin conjugating enzyme E2 H
  • Synthesis of active ubiquitin: roles of E1 and E2 enzymes
  • Antigen processing: Ubiquitination & Proteasome degradation
UBXN11 UBX domain protein 11
VPS37B VPS37B subunit of ESCRT-I
  • Budding and maturation of HIV virion
  • Membrane binding and targetting of GAG proteins
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • HCMV Late Events
  • Late endosomal microautophagy
VPS37C VPS37C subunit of ESCRT-I
  • Budding and maturation of HIV virion
  • Membrane binding and targetting of GAG proteins
  • Endosomal Sorting Complex Required For Transport (ESCRT)
  • HCMV Late Events
  • Late endosomal microautophagy
ZBTB24 zinc finger and BTB domain containing 24
ZGPAT zinc finger CCCH-type and G-patch domain containing
ZNF576 zinc finger protein 576