GCC1 and DNAJA3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		GCC1	DNAJA3
Description		GRIP and coiled-coil domain containing 1	DnaJ heat shock protein family (Hsp40) member A3
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Golgi Apparatus Cytosol	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Actin Filament Extrinsic Component Of Plasma Membrane Cell Junction Neuromuscular Junction Intracellular Membrane-bounded Organelle Postsynaptic Membrane
	Molecular Function	Protein Binding	Protein Binding ATP Binding Hsp70 Protein Binding GTPase Regulator Activity Metal Ion Binding Unfolded Protein Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Mitochondrial DNA Replication Protein Folding Activation-induced Cell Death Of T Cells Mitochondrion Organization Small GTPase Mediated Signal Transduction Cell Aging Negative Regulation Of Cell Proliferation Response To Heat T Cell Differentiation In Thymus Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Negative Regulation Of Programmed Cell Death Regulation Of Catalytic Activity Skeletal Muscle Acetylcholine-gated Channel Clustering
Pathways		Retrograde transport at the Trans-Golgi-Network
Drugs
Diseases
GWAS		Feeling worry ( 29500382) General cognitive ability ( 29844566) Intelligence (MTAG) ( 29326435) Medication adherence in chronic diseases ( 25317111) Type 2 diabetes ( 26818947 22158537 30718926)	Erectile dysfunction ( 30583798) Schizophrenia ( 28991256) Waist-to-hip ratio adjusted for BMI (additive genetic model) ( 30778226)
Interacting Genes		44 interacting genes: ABI2 ADGRE5 AMOTL2 APP ARL1 ATF4 ATN1 BIRC2 BRCA1 C1orf94 CCDC85B CEP57 CEP70 COIL CPSF7 CRHR2 DNAJA3 FAM71F2 FBF1 GLI1 GOLGA2 GTF2I HILPDA IKBKG ITSN1 KHSRP KIAA0753 KIAA1217 LZTS2 MCRS1 NAB2 NAV1 NECAB2 NINL OIP5 PAK5 PCDHA1 RBM28 SMARCD1 SPOP TFIP11 TRIM29 USHBP1 ZNF276	40 interacting genes: ATXN1 BRCA1 C2CD6 CARM1 COIL FAM131C FAM214B FBXO7 FOSL2 FRMD6 GCC1 GFI1B GRB2 HSPA1A HSPA8 IFNGR2 INPP5J JAK2 KDM1A KRAS MCPH1 MET MYO15B NFKBIA NFKBIB NOC4L NTRK1 OSGIN1 PRMT6 RAD51 RASA1 RELA RNF34 SMAD9 SMARCB1 STK16 TCF19 USP7 VHL ZBTB22
Entrez ID		79571	9093
HPRD ID		07599	09758
Ensembl ID		ENSG00000179562	ENSG00000103423
Uniprot IDs		A4D0Z4 Q96CN9	B3KM81 Q53G26 Q59E88 Q96EY1
PDB IDs			2CTT 2DN9
Enriched GO Terms of Interacting Partners?
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