TOP1 and NCL

  • Number of citations of the paper that reports this interaction (PubMedID 8567649)
  • 22
  • Data Source:
  • BioGRID (affinity chromatography technology)
  • HPRD (in vitro, in vivo)

TOP1

NCL

Description DNA topoisomerase I nucleolin
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309)
  • Antipsychotic drug-induced weight gain in schizophrenia ( 31447353)
  • Cholesterol, total ( 24097068 20686565)
  • LDL cholesterol ( 24097068 20686565)
  • LDL cholesterol levels ( 28334899)
  • LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Male-pattern baldness ( 28196072)
  • Metabolite levels ( 23823483)
  • Total cholesterol levels ( 28334899)
  • Urate levels ( 31578528)
  • Attention deficit hyperactivity disorder ( 23728934)
  • Common carotid intima-media thickness in HIV negative individuals ( 29206233)
  • Eating disorders (purging via substances) ( 23568457)
  • Height ( 31562340)
  • Noise-induced hearing loss ( 26121033)
Interacting Genes 59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6 53 interacting genes: ADAP1 ADAP2 CD3E CD3EAP CDK1 CDKN2A CLK1 CSNK2A1 CSNK2A2 ERG ESR1 ETS1 FMR1 GRB2 GZF1 GZMA H1-2 H2AC20 H2AX H2BC21 H3-4 HMGA1 IL7R MDC1 MDK MDM2 MYB MYBL1 NBN NDRG1 NPM1 NR3C1 PARP1 PPARGC1A PPM1D PRKCZ PRMT5 PTGS1 RAD51 S100A11 SREK1 SRPK2 SSB STAU1 TERF2 TERT TOP1 TP53 VHL XRCC6 YWHAQ ZFP36 ZNF689
Entrez ID 7150 4691
HPRD ID 00535 01245
Ensembl ID ENSG00000198900 ENSG00000115053
Uniprot IDs P11387 Q9BVT2 B3KM80 P19338
PDB IDs 1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8 2FC8 2FC9 2KRR
Enriched GO Terms of Interacting Partners?
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