TOP1 and PRKDC

  • Number of citations of the paper that reports this interaction (PubMedID 28415827)
  • 4
  • Data Source:
  • BioGRID (pull down, enzymatic study)

TOP1

PRKDC

Description DNA topoisomerase I protein kinase, DNA-activated, catalytic subunit
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309)
  • Antipsychotic drug-induced weight gain in schizophrenia ( 31447353)
  • Cholesterol, total ( 24097068 20686565)
  • LDL cholesterol ( 24097068 20686565)
  • LDL cholesterol levels ( 28334899)
  • LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535)
  • LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535)
  • Male-pattern baldness ( 28196072)
  • Metabolite levels ( 23823483)
  • Total cholesterol levels ( 28334899)
  • Urate levels ( 31578528)
Interacting Genes 59 interacting genes: APAF1 APP ATM BARD1 BRCA1 BTBD1 BTBD2 BUB3 CASP3 CASP6 CDK8 CKAP5 CSNK2A1 CSNK2A2 DDB2 ELK3 ERCC8 ERG FSHR GEMIN4 IL7R IRF4 IRF8 IRF9 JAK1 JUN KMT2A LIG4 LSM4 MDM2 NCL NCOA6 PDE10A PPP2R2B PRB1 PRKDC PYGM RBL1 RBL2 RCVRN SF3B1 SFPQ SNRNP70 SNW1 SRPK2 SRSF1 SRSF11 SUMO1 SYMPK TARBP2 TDP1 TOPORS TP53 TRIM32 TUBD1 U2AF2 UBE2I XRCC5 XRCC6 89 interacting genes: ABL1 AICDA AKT1 AKT2 AP1B1 ATM ATRIP BRCA1 C1D CASP3 CCNB1 CHEK1 CHEK2 CHUK CIB1 CLK1 CTDP1 DCAF1 DCLRE1C E4F1 EIF2S2 EIF4EBP1 EP300 ERG FH GSK3A GSK3B GZMB H1-1 H1-2 H2AX HDAC3 HMGB1 HMGB2 HNRNPA1 HNRNPC HOXC4 HSF1 HSP90AA1 IKBKB ILF2 JUN KAT2A LIG4 LYN MAPK8 MBP MKNK1 MRE11 MTNR1B NBN NCF1 NCF2 NCF4 NCOA6 NR3C1 PARP1 PCNA PDX1 PGR POU2F1 PPP6C PPP6R1 PPP6R3 PRKCD RAD17 RASSF1 RBBP8 RPA1 RPA2 SGO1 SP1 SRF SUMO2 THRA THRB TOP1 TP53 TREX1 UBE2I USF1 WRN XPA XRCC4 XRCC5 XRCC6 YWHAG YWHAQ ZBTB7A
Entrez ID 7150 5591
HPRD ID 00535 02941
Ensembl ID ENSG00000198900 ENSG00000253729
Uniprot IDs P11387 Q9BVT2 P78527
PDB IDs 1A31 1A35 1A36 1EJ9 1K4S 1K4T 1LPQ 1NH3 1R49 1RR8 1RRJ 1SC7 1SEU 1T8I 1TL8 5LUQ 5W1R 5Y3R
Enriched GO Terms of Interacting Partners?
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