RGS1 and GNAO1

Number of citations of the paper that reports this interaction (PubMedID 15215290)
25

Data Source:
HPRD (two hybrid, in vivo)

		RGS1	GNAO1
Description		regulator of G protein signaling 1	G protein subunit alpha o1
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events	PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs
Diseases
GWAS		Celiac disease ( 22057235 20190752 18311140) Multiple sclerosis ( 24076602 21833088 27386562) Systemic lupus erythematosus ( 28714469)	Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)
Interacting Genes		9 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 TSC22D1 UTP14A	34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR
Entrez ID		5996	2775
HPRD ID		15968	00757
Ensembl ID		ENSG00000090104	ENSG00000087258
Uniprot IDs		Q08116	B3KP89 P09471 Q6AWC5 Q8N6I9
PDB IDs		2BV1 2GTP	6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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