GNAO1 and ADRA2A

Number of citations of the paper that reports this interaction (PubMedID 7887906)
2

Data Source:
HPRD (in vitro, in vivo)

		GNAO1	ADRA2A
Description		G protein subunit alpha o1	adrenoceptor alpha 2A
Image
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Receptor Complex
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Protein Kinase Binding Alpha-1B Adrenergic Receptor Binding Alpha-2C Adrenergic Receptor Binding Thioesterase Binding Heterotrimeric G-protein Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction	Positive Regulation Of Cytokine Production Regulation Of Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Ras Protein Signal Transduction Rho Protein Signal Transduction Cell-cell Signaling Behavior Positive Regulation Of Cell Proliferation Negative Regulation Of Norepinephrine Secretion Regulation Of Vasoconstriction Actin Cytoskeleton Organization Platelet Activation Positive Regulation Of Cell Migration Activation Of Protein Kinase Activity Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Cellular Response To Hormone Stimulus Receptor Transactivation Glucose Homeostasis Positive Regulation Of Potassium Ion Transport Positive Regulation Of MAP Kinase Activity Positive Regulation Of MAPK Cascade Positive Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Calcium Ion-dependent Exocytosis Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Intestinal Absorption Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Calcium Ion Transport Negative Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Adenylate Cyclase-inhibiting Adrenergic Receptor Signaling Pathway Phospholipase C-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Wound Healing Negative Regulation Of Calcium Ion Transmembrane Transporter Activity
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor Adrenaline,noradrenaline inhibits insulin secretion G alpha (i) signalling events G alpha (z) signalling events Surfactant metabolism
Drugs			Amphetamine Bethanidine Ziprasidone Cabergoline Ropinirole Dihydroergotamine Amitriptyline Olanzapine Clozapine Norepinephrine Mirtazapine Phenylpropanolamine Loxapine Pramipexole Dipivefrin Prazosin Chlorpromazine Brimonidine Nortriptyline Amoxapine Amoxapine Clonidine Lisuride Guanabenz Dexmedetomidine Trazodone Epinephrine Phentolamine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Epinastine Tolazoline Fenoldopam Dobutamine Pseudoephedrine Benzphetamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Methyldopa Guanfacine Ergoloid mesylate Carvedilol Doxepin Nefazodone Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Mephentermine Yohimbine Methotrimeprazine 4-Methoxyamphetamine Methamphetamine Propericiazine Zuclopenthixol Dronedarone Lofexidine Epicept NP-1 Mianserin Asenapine Droxidopa Flupirtine Esmirtazapine Xylometazoline Levonordefrin Naphazoline Lurasidone Dosulepin Etoperidone Cirazoline Moxonidine Setiptiline Rilmenidine Tiapride
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Fasting blood glucose ( 20081858 22581228) Fasting blood glucose (BMI interaction) ( 22581228) Homeostasis model assessment of beta-cell function ( 20081858) Longitudinal alcohol consumption ( 26081443) Platelet aggregation ( 20526338 29185836)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	14 interacting genes: ADRB1 EIF2B1 GGA3 GNAI1 GNAI2 GNAO1 GNB1 GNG2 GRK2 PPP1R9B PRKCD SNTA1 UCHL1 YWHAZ
Entrez ID		2775	150
HPRD ID		00757	00078
Ensembl ID		ENSG00000087258	ENSG00000150594
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	P08913
PDB IDs		6FUF 6G79 6OIK	1HLL 1HO9 1HOD 1HOF
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?