GNAO1 and RGS19

Number of citations of the paper that reports this interaction (PubMedID 8986788)
44

Data Source:
HPRD (in vitro, two hybrid)

		GNAO1	RGS19
Description		G protein subunit alpha o1	regulator of G protein signaling 19
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GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body	Golgi Apparatus Plasma Membrane Brush Border Membrane Clathrin-coated Vesicle Membrane Raft
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	G-protein Alpha-subunit Binding GTPase Activity Protein Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction	Autophagy G Protein-coupled Receptor Signaling Pathway Small GTPase Mediated Signal Transduction Negative Regulation Of Signal Transduction Response To Ethanol
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events G alpha (z) signalling events
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Chronic kidney disease ( 31152163) Estimated glomerular filtration rate ( 31152163) Mean corpuscular volume ( 27863252) Systolic blood pressure ( 30578418)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	15 interacting genes: CSNK2A1 CSNK2A2 GDE1 GIPC1 GNAI1 GNAI2 GNAI3 GNAO1 GNAZ MAPK1 MAPK6 OPRL1 OSTM1 PRKCA TGFBR1
Entrez ID		2775	10287
HPRD ID		00757	05461
Ensembl ID		ENSG00000087258	ENSG00000171700
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	B4DP94 P49795
PDB IDs		6FUF 6G79 6OIK	1CMZ
Enriched GO Terms of Interacting Partners?
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