RGS1 and GIPC1

Number of citations of the paper that reports this interaction (PubMedID 11251075)
53

Data Source:
HPRD (in vivo)

		RGS1	GIPC1
Description		regulator of G protein signaling 1	GIPC PDZ domain containing family member 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse
	Molecular Function	G-protein Alpha-subunit Binding GTPase Activity GTPase Activator Activity Calmodulin Binding	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding
	Biological Process	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Bacterium Negative Regulation Of Signal Transduction Positive Regulation Of GTPase Activity Leukotriene Signaling Pathway	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis
Pathways		G alpha (q) signalling events G alpha (i) signalling events G alpha (i) signalling events
Drugs
Diseases
GWAS		Celiac disease ( 22057235 20190752 18311140) Multiple sclerosis ( 24076602 21833088 27386562) Systemic lupus erythematosus ( 28714469)	Kidney stones ( 31729369)
Interacting Genes		9 interacting genes: APP FBXO7 FUNDC2 GDE1 GIPC1 GNAO1 MAP3K12 TSC22D1 UTP14A	37 interacting genes: ACTN1 ADRB1 ARHGEF12 BRD4 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408
Entrez ID		5996	10755
HPRD ID		15968	05462
Ensembl ID		ENSG00000090104	ENSG00000123159
Uniprot IDs		Q08116	A0A024R7I0 A0A024R7I1 A8K2I7 O14908
PDB IDs		2BV1 2GTP
Enriched GO Terms of Interacting Partners?
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