GIPC1 and LPAR2

Number of citations of the paper that reports this interaction (PubMedID 23145131)
19

Data Source:
BioGRID (pull down)

		GIPC1	LPAR2
Description		GIPC PDZ domain containing family member 1	lysophosphatidic acid receptor 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Brush Border Cell Cortex Synaptic Vesicle Vesicle Membrane Membrane Endocytic Vesicle Cytoplasmic Vesicle Dendritic Spine Dendritic Shaft Extracellular Exosome Schaffer Collateral - CA1 Synapse Glutamatergic Synapse	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Endocytic Vesicle
	Molecular Function	Actin Binding Signaling Receptor Binding Protein Binding Myosin Binding PDZ Domain Binding Identical Protein Binding Cadherin Binding	G Protein-coupled Receptor Activity Protein Binding Lipid Binding Lysophosphatidic Acid Receptor Activity
	Biological Process	Protein Targeting G Protein-coupled Receptor Signaling Pathway Chemical Synaptic Transmission Glutamate Secretion Positive Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Protein Stability Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Cytokinesis Endothelial Cell Migration Positive Regulation Of Melanin Biosynthetic Process Regulation Of Synaptic Plasticity Cellular Response To Interleukin-7 Regulation Of Synaptic Vesicle Exocytosis	G Protein-coupled Receptor Signaling Pathway Activation Of Phospholipase C Activity Positive Regulation Of Cytosolic Calcium Ion Concentration
Pathways			G alpha (q) signalling events G alpha (i) signalling events Lysosphingolipid and LPA receptors
Drugs
Diseases
GWAS		Kidney stones ( 31729369)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Bipolar II disorder ( 31043756) Schizophrenia ( 23974872) Sphingolipid levels ( 22359512)
Interacting Genes		37 interacting genes: ACTN1 ADRB1 ARHGEF12 BRD4 CARD10 CD93 DDIT3 DRD2 DRD3 FZD3 GSK3B IGF1R ITGA5 ITGA6 KIF1B LHCGR LPAR1 LPAR2 LRP1 LRP2 LRP8 MYO6 NRP1 NTRK1 NTRK2 RGS1 RGS19 SDC4 SEMA4B SEMA4C SH3BP4 SLC2A1 TGFBR3 TPBG TYRP1 ZFPM1 ZNF408	7 interacting genes: ARHGEF11 ARHGEF12 ATXN1 GIPC1 SLC9A3R1 SLC9A3R2 TRIP6
Entrez ID		10755	9170
HPRD ID		05462	05487
Ensembl ID		ENSG00000123159	ENSG00000064547
Uniprot IDs		A0A024R7I0 A0A024R7I1 A8K2I7 O14908	A0A024R7M9 Q9HBW0
PDB IDs			4P0C
Enriched GO Terms of Interacting Partners?
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