DUS2 and EPRS1

Number of citations of the paper that reports this interaction (PubMedID 15994936)
28

Data Source:
HPRD (in vivo)

		DUS2	EPRS1
Description		dihydrouridine synthase 2	glutamyl-prolyl-tRNA synthetase 1
Image
GO Annotations	Cellular Component	Endoplasmic Reticulum Cytosol	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex
	Molecular Function	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding
	Biological Process	TRNA Dihydrouridine Synthesis Negative Regulation Of Protein Kinase Activity Oxidation-reduction Process Negative Regulation Of Cell Death	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell
Pathways		tRNA modification in the nucleus and cytosol	Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol
Drugs			Glutamic Acid L-Proline '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS		Schizophrenia ( 29483656)
Interacting Genes		4 interacting genes: EPRS1 NECTIN2 SMN1 TK1	12 interacting genes: AIMP2 ARL4D DUS2 EEF1D ESR1 HSP90AA1 IARS1 NEDD4 NELFCD RARS1 SYNCRIP TAB1
Entrez ID		54920	2058
HPRD ID		08624	00703
Ensembl ID		ENSG00000167264	ENSG00000136628
Uniprot IDs		A0A024R6Z7 B4DKP8 E7EUN9 Q9NX74	P07814
PDB IDs		4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00	1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6
Enriched GO Terms of Interacting Partners?
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