EPRS1 and DUS2

Number of citations of the paper that reports this interaction (PubMedID 15994936)
28

Data Source:
HPRD (in vivo)

		EPRS1	DUS2
Description		glutamyl-prolyl-tRNA synthetase 1	dihydrouridine synthase 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex	Endoplasmic Reticulum Cytosol
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding	Double-stranded RNA Binding Protein Kinase Inhibitor Activity Protein Binding FMN Binding TRNA Dihydrouridine Synthase Activity Flavin Adenine Dinucleotide Binding NADPH Binding TRNA-dihydrouridine20 Synthase Activity
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell	TRNA Dihydrouridine Synthesis Negative Regulation Of Protein Kinase Activity Oxidation-reduction Process Negative Regulation Of Cell Death
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol	tRNA modification in the nucleus and cytosol
Drugs		Glutamic Acid L-Proline '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS			Schizophrenia ( 29483656)
Interacting Genes		12 interacting genes: AIMP2 ARL4D DUS2 EEF1D ESR1 HSP90AA1 IARS1 NEDD4 NELFCD RARS1 SYNCRIP TAB1	4 interacting genes: EPRS1 NECTIN2 SMN1 TK1
Entrez ID		2058	54920
HPRD ID		00703	08624
Ensembl ID		ENSG00000136628	ENSG00000167264
Uniprot IDs		P07814	A0A024R6Z7 B4DKP8 E7EUN9 Q9NX74
PDB IDs		1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6	4WFS 4WFT 4XP7 5OC4 5OC5 5OC6 6EI8 6EZA 6EZB 6EZC 6F00
Enriched GO Terms of Interacting Partners?
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