EPRS1 and EEF1D

Number of citations of the paper that reports this interaction (PubMedID 20195357)
30

Data Source:
BioGRID (pull down)

		EPRS1	EEF1D
Description		glutamyl-prolyl-tRNA synthetase 1	eukaryotic translation elongation factor 1 delta
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex GAIT Complex Ribonucleoprotein Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Cytosol Eukaryotic Translation Elongation Factor 1 Complex
	Molecular Function	Glutamate-tRNA Ligase Activity Proline-tRNA Ligase Activity Protein Binding ATP Binding Zinc Ion Binding RNA Stem-loop Binding Identical Protein Binding Protein Homodimerization Activity GTPase Binding	DNA Binding Translation Elongation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Translation Factor Activity, RNA Binding Cadherin Binding
	Biological Process	TRNA Aminoacylation For Protein Translation Glutamyl-tRNA Aminoacylation Prolyl-tRNA Aminoacylation Negative Regulation Of Translation Cellular Response To Insulin Stimulus Protein-containing Complex Assembly Cellular Response To Interferon-gamma Regulation Of Long-chain Fatty Acid Import Into Cell	Translational Elongation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Ionizing Radiation
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation tRNA modification in the nucleus and cytosol	Eukaryotic Translation Elongation
Drugs		Glutamic Acid L-Proline '5'-O-(N-(L-Prolyl)-Sulfamoyl)Adenosine 5'-O-(N-(L-Cysteinyl)-Sulfamoyl)Adenosine '5'-O-(N-(L-Alanyl)-Sulfamoyl)Adenosine
Diseases
GWAS			Schizophrenia ( 31268507)
Interacting Genes		12 interacting genes: AIMP2 ARL4D DUS2 EEF1D ESR1 HSP90AA1 IARS1 NEDD4 NELFCD RARS1 SYNCRIP TAB1	38 interacting genes: APP ARHGAP21 ASCC2 ATG7 CAMSAP2 CD48 CDK1 CDK9 CRMP1 CSNK2A1 CTBP1 CTBP2 ECH1 EEF1G EPRS1 ERP27 FOS FRA10AC1 GARS1 HEXD HSF1 KARS1 KTN1 MAP1B NR2F1 POT1 PRKCA RELA RNF40 RPS6KA1 SIAH1 SIAH2 SQSTM1 TERF1 TINF2 TPT1 UBE2A VARS1
Entrez ID		2058	1936
HPRD ID		00703	00560
Ensembl ID		ENSG00000136628	ENSG00000104529
Uniprot IDs		P07814	B2RAR6 D3DWK1 P29692
PDB IDs		1FYJ 4HVC 4K86 4K87 4K88 5A1N 5A34 5A5H 5BMU 5V58 5VAD 5Y6L 6IY6	2MVM 2MVN 2N51 5JPO
Enriched GO Terms of Interacting Partners?
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