PDZK1 and ABCC4

Number of citations of the paper that reports this interaction (PubMedID 28514442)
199

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PDZK1	ABCC4
Description		PDZ domain containing 1	ATP binding cassette subfamily C member 4
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Brush Border Apical Plasma Membrane Brush Border Membrane Microvillus Membrane Membrane Raft Extracellular Exosome	Plasma Membrane Membrane Integral Component Of Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane
	Molecular Function	Scavenger Receptor Binding Protein Binding PDZ Domain Binding Protein-containing Complex Binding	Protein Binding ATP Binding Efflux Transmembrane Transporter Activity ATPase Activity, Coupled To Transmembrane Movement Of Ions, Phosphorylative Mechanism 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity
	Biological Process	Carnitine Transport Positive Regulation Of Ion Transmembrane Transporter Activity Regulation Of Anion Transport Positive Regulation Of Protein Targeting To Membrane Positive Regulation Of Cation Transmembrane Transport Positive Regulation Of Protein Localization To Membrane Drug Transmembrane Export	Platelet Degranulation Response To Organonitrogen Compound Response To Organic Cyclic Compound Prostaglandin Secretion Ion Transmembrane Transport Response To Drug Xenobiotic Transport Positive Regulation Of Smooth Muscle Cell Proliferation Transmembrane Transport Oxidation-reduction Process Cilium Assembly Export Across Plasma Membrane
Pathways			Platelet degranulation ABC-family proteins mediated transport
Drugs			ATP
Diseases
GWAS		Contrast sensitivity ( 24152035) Serum uric acid levels ( 30993211) Urate levels ( 20884846 31578528 23263486) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597)	Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Blood metabolite levels ( 24816252) Breast cancer ( 17903305) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 29403010 27863252) Plateletcrit ( 27863252) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653)
Interacting Genes		29 interacting genes: ABCA1 ABCC2 ABCC4 AKAP10 APP CFTR CLCN3 CRHR1 FARP2 GFAP PDZK1IP1 PEX5 RPS6KA1 SCARB1 SLC15A2 SLC17A1 SLC22A11 SLC22A12 SLC22A4 SLC22A5 SLC26A6 SLC34A1 SLC9A3 SLC9A3R1 SLC9A3R2 SLCO1A2 SLK SSTR5 UBE2I	6 interacting genes: ERBIN MPP1 PDZK1 SLC9A3R1 SLC9A3R2 SNTA1
Entrez ID		5174	10257
HPRD ID		04829	05583
Ensembl ID		ENSG00000174827	ENSG00000125257
Uniprot IDs		Q5T2W1	A8K2Q2 O15439
PDB IDs		2EEI 2EEJ 2VSP 3TMH 4Q2P 6EZI
Enriched GO Terms of Interacting Partners?
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