LARP7 and CHRNB4

		LARP7	CHRNB4
Description		La ribonucleoprotein 7, transcriptional regulator	cholinergic receptor nicotinic beta 4 subunit
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GO Annotations	Cellular Component	Nucleoplasm Cytosol Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane Cholinergic Synapse
	Molecular Function	RNA Binding Protein Binding	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Protein-containing Complex Binding
	Biological Process	RNA Processing	Action Potential Ion Transport Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Locomotory Behavior Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition
Pathways			Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation
Drugs			Nicotine Dextromethorphan Galantamine Ethanol Pentolinium Levomethadyl Acetate Epibatidine
Diseases
GWAS		Body mass index ( 26426971) Dental caries (decayed and filled deciduous teeth) ( 31533690)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)
Interacting Genes		16 interacting genes: APP CHRNB4 GABRG2 GAR1 JMJD6 LRRK2 MCUB OSTC PAPSS1 PPA2 PRPF40A PUF60 RN7SK RRH SMS ZGRF1	6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 LARP7 UBQLN1
Entrez ID		51574	1143
HPRD ID		17095	00337
Ensembl ID		ENSG00000174720	ENSG00000117971
Uniprot IDs		Q4G0J3	P30926
PDB IDs		4WKR 5KNW 6D12	2ASG 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
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