CHRNB4 and CHRNA2

Number of citations of the paper that reports this interaction (PubMedID 8906617)
14

Data Source:
HPRD (in vitro, in vivo)

		CHRNB4	CHRNA2
Description		cholinergic receptor nicotinic beta 4 subunit	cholinergic receptor nicotinic alpha 2 subunit
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Specific Granule Membrane Neuron Projection Synapse Postsynaptic Membrane Tertiary Granule Membrane Cholinergic Synapse	Plasma Membrane Integral Component Of Plasma Membrane Acetylcholine-gated Channel Complex Integral Component Of Membrane Cell Junction Neuron Projection Synapse Postsynaptic Membrane
	Molecular Function	Protein Binding Ligand-gated Ion Channel Activity Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Protein-containing Complex Binding	Acetylcholine Receptor Activity Acetylcholine-gated Cation-selective Channel Activity Acetylcholine Binding Protein-containing Complex Binding
	Biological Process	Action Potential Ion Transport Smooth Muscle Contraction Regulation Of Smooth Muscle Contraction Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Locomotory Behavior Ion Transmembrane Transport Response To Nicotine Behavioral Response To Nicotine Regulation Of Membrane Potential Neutrophil Degranulation Regulation Of Neurotransmitter Secretion Nervous System Process Positive Regulation Of Transmission Of Nerve Impulse Excitatory Postsynaptic Potential Synaptic Transmission Involved In Micturition	Ion Transport Signal Transduction Chemical Synaptic Transmission Synaptic Transmission, Cholinergic Neuromuscular Synaptic Transmission Ion Transmembrane Transport Response To Nicotine Regulation Of Membrane Potential Nervous System Process Excitatory Postsynaptic Potential
Pathways		Highly sodium permeable postsynaptic acetylcholine nicotinic receptors Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors Neutrophil degranulation	Highly calcium permeable postsynaptic nicotinic acetylcholine receptors Highly calcium permeable nicotinic acetylcholine receptors
Drugs		Nicotine Dextromethorphan Galantamine Ethanol Pentolinium Levomethadyl Acetate Epibatidine	Nicotine Carbachol Metocurine Iodide Gallamine Triethiodide Dextromethorphan Cisatracurium besylate Mecamylamine Galantamine Procaine Rocuronium Atracurium besylate Biperiden Ethanol Doxacurium chloride Tubocurarine Mivacurium Decamethonium Metocurine Pancuronium Pipecuronium Vecuronium RPI-78M Epibatidine
Diseases			Autosomal dominant nocturnal frontal lobe epilepsy (ADNFLE); Nocturnal frontal lobe epilepsy (NFLE)
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Attention function in attention deficit hyperactive disorder ( 26174813) Autism spectrum disorder or schizophrenia ( 28540026) BMI (smoking interaction) ( 28443625) BMI in smokers ( 28443625) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Chronic obstructive pulmonary disease ( 30804561) Diffusing capacity of carbon monoxide ( 30694715) Exhaled carbon monoxide levels ( 25072098) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730 18385738 18780872) Lung cancer in ever smokers ( 28604730) Nicotine dependence ( 18385739 26440539) Post bronchodilator FEV1 ( 26634245) Post bronchodilator FEV1/FVC ratio ( 26634245) Post bronchodilator FEV1/FVC ratio in COPD ( 26634245) Schizophrenia ( 25056061 29483656) Small cell lung carcinoma ( 28604730) Smoking status (heavy vs light) ( 28520984) Squamous cell lung carcinoma ( 28604730) Sudden cardiac arrest ( 21658281)	Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Autism spectrum disorder or schizophrenia ( 28540026) Cannabis use disorder ( 31209380) Lung cancer ( 28604730) Response to zileuton treatment in asthma (FEV1 change interaction) ( 26031901) Schizophrenia ( 29483656)
Interacting Genes		6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 LARP7 UBQLN1	2 interacting genes: CHRNB2 CHRNB4
Entrez ID		1143	1135
HPRD ID		00337	00332
Ensembl ID		ENSG00000117971	ENSG00000120903
Uniprot IDs		P30926	Q15822
PDB IDs		2ASG 6PV7 6PV8	5FJV
Enriched GO Terms of Interacting Partners?
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