CHRNB4 and CHRNA3

  • Number of citations of the paper that reports this interaction (PubMedID 1689727)
  • 57
  • Data Source:
  • HPRD (in vitro)

CHRNB4

CHRNA3

Description cholinergic receptor nicotinic beta 4 subunit cholinergic receptor nicotinic alpha 3 subunit
Image
GO Annotations Cellular Component
Molecular Function
Biological Process
Pathways
Drugs
Diseases
GWAS
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Attention function in attention deficit hyperactive disorder ( 26174813)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • BMI (smoking interaction) ( 28443625)
  • BMI in smokers ( 28443625)
  • Body mass index (joint analysis main effects and smoking interaction) ( 28443625)
  • Chronic obstructive pulmonary disease ( 30804561)
  • Diffusing capacity of carbon monoxide ( 30694715)
  • Exhaled carbon monoxide levels ( 25072098)
  • Lung adenocarcinoma ( 28604730)
  • Lung cancer ( 28604730 18385738 18780872)
  • Lung cancer in ever smokers ( 28604730)
  • Nicotine dependence ( 18385739 26440539)
  • Post bronchodilator FEV1 ( 26634245)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Schizophrenia ( 25056061 29483656)
  • Small cell lung carcinoma ( 28604730)
  • Smoking status (heavy vs light) ( 28520984)
  • Squamous cell lung carcinoma ( 28604730)
  • Sudden cardiac arrest ( 21658281)
  • anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028)
  • Autism spectrum disorder or schizophrenia ( 28540026)
  • Chronic bronchitis and chronic obstructive pulmonary disease ( 25241909)
  • Chronic obstructive pulmonary disease ( 22080838 30804561 19300482 25101718 20173748)
  • Chronic obstructive pulmonary disease (moderate to severe) ( 24621683)
  • Chronic obstructive pulmonary disease (severe) ( 24621683)
  • Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203)
  • Cotinine levels in smokers with chronic obstructive pulmonary disease ( 29631575)
  • Current cigarettes per day in chronic obstructive pulmonary disease ( 29767774)
  • Dentures ( 31235808)
  • Diffusing capacity of carbon monoxide ( 30694715)
  • Emphysema distribution in smoking ( 27669027)
  • Emphysema imaging phenotypes ( 26030696)
  • Exhaled carbon monoxide levels ( 25072098)
  • Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575)
  • Familial lung cancer ( 29924316)
  • Local histogram emphysema pattern ( 25006744)
  • Lung adenocarcinoma ( 19836008)
  • Lung cancer ( 18385676 18385738 19654303 18780872 30104567)
  • Lung cancer in ever smokers ( 30104567)
  • Lung function (FEV1/FVC) ( 31453325)
  • Lung function (FEV1/FVC) variance ( 31453325)
  • Nicotine dependence ( 18385739 26440539)
  • Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808)
  • Obesity-related traits ( 23251661)
  • Parental lifespan ( 29030599)
  • Parental longevity (combined parental attained age, Martingale residuals) ( 29227965)
  • Parental longevity (father's attained age) ( 29227965)
  • Parental longevity (mother's attained age) ( 29227965)
  • Peripheral artery disease ( 31285632)
  • Post bronchodilator FEV1 ( 26634245)
  • Post bronchodilator FEV1 in COPD ( 26634245)
  • Post bronchodilator FEV1/FVC ratio ( 26634245)
  • Post bronchodilator FEV1/FVC ratio in COPD ( 26634245)
  • Pre bronchodilator FEV1 ( 26634245)
  • Pre bronchodilator FEV1/FVC ratio ( 26634245)
  • Pulmonary artery enlargement and chronic obstructive pulmonary disease ( 25101718)
  • Pulmonary function ( 21946350)
  • Pulmonary function (smoking interaction) ( 23284291)
  • Schizophrenia ( 28991256 25056061 29483656 30285260)
  • Serum albumin level ( 23022100)
  • Smoking behavior ( 20418889 20418890)
  • Smoking behaviour (cigarettes smoked per day) ( 31089300 30617275)
  • Smoking status (heavy vs light) ( 28520984)
  • Squamous cell lung carcinoma ( 28604730)
Interacting Genes 6 interacting genes: CHRNA2 CHRNA3 CHRNA4 CHRNA5 LARP7 UBQLN1 3 interacting genes: CHRNB4 ETFA UBQLN1
Entrez ID 1143 1136
HPRD ID 00337 07511
Ensembl ID ENSG00000117971 ENSG00000080644
Uniprot IDs P30926 P32297
PDB IDs 2ASG 6PV7 6PV8 4ZK4 5SYO 5TVC 6PV7 6PV8
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?