SIRT6 and USP10

Number of citations of the paper that reports this interaction (PubMedID 29698567)
2

Data Source:
BioGRID (pull down, pull down)

		SIRT6	USP10
Description		sirtuin 6	ubiquitin specific peptidase 10
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Cytoplasm	Nucleus Nucleoplasm Cytoplasm Early Endosome Cytosol Protein-containing Complex
	Molecular Function	Chromatin Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity Ion Channel Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Base-excision Repair Protein ADP-ribosylation Protein Deacetylation Negative Regulation Of Cell Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Destabilization Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Glucose Homeostasis Negative Regulation Of Glycolytic Process Negative Regulation Of Glucose Import Positive Regulation Of Fibroblast Proliferation Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Telomeric Heterochromatin Assembly Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation Positive Regulation Of Stem Cell Proliferation	Ubiquitin-dependent Protein Catabolic Process Autophagy Cellular Response To DNA Damage Stimulus Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Cellular Response To Interleukin-1
Pathways		Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends	Termination of translesion DNA synthesis Ub-specific processing proteases
Drugs
Diseases
GWAS			Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252)
Interacting Genes		17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM	13 interacting genes: AR G3BP1 H2AC20 IKBKG MSH2 NOTCH1 PRKAA2 RAD51 SCNN1A SCNN1G SIRT6 SNX3 UBC
Entrez ID		51548	9100
HPRD ID		12093	07029
Ensembl ID		ENSG00000077463	ENSG00000103194
Uniprot IDs		B4DDV3 M0QXA0 M0R1N9 Q8N6T7	Q14694
PDB IDs		3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY
Enriched GO Terms of Interacting Partners?
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