SIRT6 and TSPYL2

Number of citations of the paper that reports this interaction (PubMedID 23240041)
9

Data Source:
BioGRID (two hybrid)

		SIRT6	TSPYL2
Description		sirtuin 6	TSPY like 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Telomeric Heterochromatin Nucleolus Cytoplasm	Nucleus Nucleoplasm Nucleolus Cytoplasm
	Molecular Function	Chromatin Binding Transcription Corepressor Activity NAD+ ADP-ribosyltransferase Activity NAD(P)+-protein-arginine ADP-ribosyltransferase Activity Histone Deacetylase Activity Protein Binding Zinc Ion Binding NAD-dependent Histone Deacetylase Activity Deacetylase Activity NAD-dependent Protein Deacetylase Activity NAD-dependent Histone Deacetylase Activity (H3-K9 Specific) NAD+ Binding	RDNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Post-embryonic Cardiac Muscle Cell Growth Involved In Heart Morphogenesis Base-excision Repair Protein ADP-ribosylation Protein Deacetylation Negative Regulation Of Cell Proliferation Regulation Of Double-strand Break Repair Via Homologous Recombination Protein Destabilization Response To Nutrient Levels Positive Regulation Of Chromatin Silencing At Telomere Positive Regulation Of Telomere Maintenance Glucose Homeostasis Negative Regulation Of Glycolytic Process Negative Regulation Of Glucose Import Positive Regulation Of Fibroblast Proliferation Histone H3-K9 Modification Histone H3 Deacetylation Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Transcription Factor Catabolic Process Positive Regulation Of Chondrocyte Proliferation Positive Regulation Of Telomeric Heterochromatin Assembly Positive Regulation Blood Vessel Branching Positive Regulation Of Vascular Endothelial Cell Proliferation Histone H3-K9 Deacetylation Positive Regulation Of Stem Cell Proliferation	Nucleosome Assembly Cell Cycle Negative Regulation Of DNA Replication Regulation Of Signal Transduction Negative Regulation Of Cell Growth IRE1-mediated Unfolded Protein Response Negative Regulation Of Cell Cycle Regulation Of Protein Kinase Activity
Pathways		Pre-NOTCH Transcription and Translation Processing of DNA double-strand break ends	XBP1(S) activates chaperone genes
Drugs
Diseases
GWAS
Interacting Genes		17 interacting genes: AKT1 CCNDBP1 CDKN1B CHD3 ELF5 FAF1 HUS1 MUTYH RAD1 SKP2 STUB1 TDG TSPYL2 UBE2D1 UBE3A USP10 VIM	10 interacting genes: APTX CASK CCNB1 CDK1 CDK2 CDK4 COIL EEF1A1 GFI1B SIRT6
Entrez ID		51548	64061
HPRD ID		12093	06713
Ensembl ID		ENSG00000077463	ENSG00000184205
Uniprot IDs		B4DDV3 M0QXA0 M0R1N9 Q8N6T7	Q9H2G4
PDB IDs		3K35 3PKI 3PKJ 3ZG6 5MF6 5MFP 5MFZ 5MGN 5X16 5Y2F 6HOY
Enriched GO Terms of Interacting Partners?
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